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Strain: BBDR.LA-(D5Rat98-D5Rat233), BBDP-(D4Mit6-D4Mit7)/Rhw

Symbol: BBDR.LA-(D5Rat98-D5Rat233), BBDP-(D4Mit6-D4Mit7)/Rhw
Strain: BBDR.LA-(D5Rat98-D5Rat233), BBDP-(D4Mit6-D4Mit7)
Substrain: Rhw
RGD ID: 6893535
Citation ID: RRID:RGD_6893535
Ontology ID: RS:0003308
Also Known As: BBDR.LA-(D5Rat98-D5Rat233), BBDP-(D4Mit6-D4Mit7)/Rhw; DR.lepr-/lepr-,Gimap5-/Gimap5-; DR.lepr-/lepr-,Gimap5-/Gimap5-
Type: congenic
Available Source: Not Available
Origination: R. H. William Laboratory, University of Washington, Seattle, Washington
Description: Heterozygous BBDR.LA-(D5Rat98-D5Rat233)/Rhw (DR.lepr) were crossed with homozygous BBDR.BBDP-(-(D4Mit6-D4Mit7)/Rhw (DR.Gimap5), to generate double congenic rats that had mutations for Gimap5 and Lepr genes.
Last Known Status: Unknown

Disease Annotations     Click to see Annotation Detail View


References - curated
# Reference Title Reference Citation
1. Differential effects of leptin receptor mutation on male and female BBDR Gimap5-/Gimap5- spontaneously diabetic rats. Moralejo DH, etal., Physiol Genomics. 2010 Mar 3;41(1):9-20. Epub 2009 Dec 8.
2. RGD Strain RSO annotation pipeline RGD Automated Pipelines


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics Hyperleptinemia was rescued and increase in islets was seen in both sexes 6893459
strain_life_disease Males were not protected from Type 1 Diabetes 6893459