Strain Report - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Strain Registration

Strain: SS-Kcnj16em1Mcwi-/-

Symbol: SS-Kcnj16em1Mcwi-/-
Strain: SS-Kcnj16em1-/-
Substrain: Mcwi
RGD ID: 6893434
Citation ID: RRID:RGD_6893434
Ontology ID: RS:0003320
Alleles: Kcnj16em1Mcwi
Also Known As: SS-Kcnj16em1Mcwi; SS-Kcnj16em1Mcwi; SS-Kcnj16^[em1Mcwi-/-]
Type: mutant
Available Source: Not Available
Origination: PhysGen Knockouts
Description: This strain was produced by injecting ZFNs targeting the sequence AGCTGCATCATAAACACCttcatcATTGGGGCAGCCTTGGCA into SS/JrHsdMcwi rat embryos. The resulting mutation is a 18-bp deletion in exon 1.
Genetic Status: Homozygous
Last Known Status: Live Animals; Cryopreserved Sperm (as of 2017-01-26)
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81096,489,329 - 96,520,745RGD_MAPPER_PIPELINE
mRatBN7.21096,018,462 - 96,018,479RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01099,330,894 - 99,391,551RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01099,027,026 - 99,087,674RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.410100,514,180 - 100,515,949RGD_MAPPER_PIPELINERGSC3.4





References

References - curated
# Reference Title Reference Citation
1. Knockout rats via embryo microinjection of zinc-finger nucleases. Geurts AM, etal., Science. 2009 Jul 24;325(5939):433.
2. Relationship between the renin-angiotensin-aldosterone system and renal Kir5.1 channels. Manis AD, etal., Clin Sci (Lond). 2019 Dec 20;133(24):2449-2461. doi: 10.1042/CS20190876.
3. Repeated seizures lead to progressive ventilatory dysfunction in SSKcnj16-/- rats. Manis AD, etal., J Appl Physiol (1985). 2023 Oct 1;135(4):872-885. doi: 10.1152/japplphysiol.00072.2023. Epub 2023 Aug 3.
4. Kcnj16 knockout produces audiogenic seizures in the Dahl salt-sensitive rat. Manis AD, etal., JCI Insight. 2021 Jan 11;6(1):e143251. doi: 10.1172/jci.insight.143251.
5. Essential role of Kir5.1 channels in renal salt handling and blood pressure control. Palygin O, etal., JCI Insight. 2017 Sep 21;2(18). pii: 92331. doi: 10.1172/jci.insight.92331. eCollection 2017 Sep 21.
6. PhysGen Knockouts PhysGen Knockout strains
7. Genetic mutation of Kcnj16 identifies Kir5.1-containing channels as key regulators of acute and chronic pH homeostasis. Puissant MM, etal., FASEB J. 2019 Apr;33(4):5067-5075. doi: 10.1096/fj.201802257R. Epub 2019 Jan 3.
8. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Kcnj16em1Mcwi-var1 chr10 96018462 96018479 CTTCATCATTGGGGCAGC - deletion mRatBN7.2

Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-10-19 SS-Kcnj16em1Mcwi-/-    SS-Kcnj16em1Mcwi    Symbol and/or name change 68913 APPROVED
2014-04-03 SS-Kcnj16em1Mcwi    SS-Kcnj16em1Mcwi    Symbol updated 68687 APPROVED
2014-04-03 SS-Kcnj16em1Mcwi    SS-Kcnj16em1Mcwi    Name updated 68913 APPROVED
2014-04-03 SS-Kcnj16em1Mcwi    SS-Kcnj16em1Mcwi    Symbol updated 68687 APPROVED
2014-04-03 SS-Kcnj16em1Mcwi    SS-Kcnj16em1Mcwi    Name updated 68913 APPROVED
2013-08-15 SS-Kcnj16em1Mcwi    SS-Kcnj16em1Mcwi    Name updated 68913 APPROVED