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Strain: WOKW

Symbol: WOKW
Strain: WOKW
RGD ID: 67935
Citation ID: RRID:RGD_67935
Ontology ID: RS:0000065
Also known as: WOK.1W
Type: inbred
Source: Dept. of Laboratory Animal Science, Inst. of Pathology, University of Greifswald,D-17495, Karlsburg, Germany
Origin: Outbred Wistar BB rats from Biobreeding Laboratories, Ottawa, Canada in 1981 to Dr.I. Kloting, Dept. of Laboratory Animal Science, Inst. of Pathology, University of Greifswald,D-17495, Karlsburg, Germany. WOKA (originally designated WOK.1A) was developed by brother x sister mating from rats homozygous for RT1a, and WOKW (originally designated WOK.1W) from rats homozygous for RT1U , a haplotype which pre-disposes to type I diabetes.
Genetic Markers: c
Coat Color: Albino
Inbred Generations: (1998) F35+
Last Known Status: Unknown

Substrains
WOKW/K





References


Region

Strain QTL Data
Symbol Name Trait
Bw41 Body weight QTL 41 body mass   (VT:0001259)    
Bw42 Body weight QTL 42 body mass   (VT:0001259)    
Bw43 Body weight QTL 43 body mass   (VT:0001259)    
Bw44 Body weight QTL 44 body mass   (VT:0001259)    
Bw45 Body weight QTL 45 body mass   (VT:0001259)    
Bw46 Body weight QTL 46 body mass   (VT:0001259)    
Bw62 Body weight QTL62 inguinal fat pad mass   (VT:0010424)    
Slep3 Serum leptin concentration QTL 3 blood leptin amount   (VT:0005667)    
Slep4 Serum leptin concentration QTL 4 blood leptin amount   (VT:0005667)    
Stl14 Serum triglyceride level QTL 14 blood triglyceride amount   (VT:0002644)    
Stl17 Serum triglyceride level QTL 17 blood triglyceride amount   (VT:0002644)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics No diabetes is observed in either strain. However, WOKW is hypertriglycemic, hyperinsulinemicand hypertensive with impaired glucose tolerance which increases with age, but it isnormoglycemic and is not obese. It has a poor reproductive performance. It may be a goodanimal model of human insulin resistance (Kovacs et al, 1997). Both strains have beencharacterised at a number of genetic marker loci, and differed from each other at 6/30 loci(Bender et al, 1994). They have also been compared with three other BB substrains using 36markers, and differ substantially both from the other strains and from each other (Kloting et al,1995). 619689
strain_characteristics No diabetes is observed in either strain. However, WOKW is hypertriglycemic, hyperinsulinemic and hypertensive with impaired glucose tolerance which increases with age, but it is normoglycemic and is not obese. It has a poor reproductive performance. It may be a good animal model of human insulin resistance (Kovacs et al, 1997). Both strains have been characterised at a number of genetic marker loci, and differed from each other at 6/30 loci(Bender et al, 1994). They have also been compared with three other BB substrains using 36 markers, and differ substantially both from the other strains and from each other (Kloting et al,1995). 619689
strain_life_disease These develop complete metabolic syndrome which resembles the human disease. 1357168