Strain Report - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Strain Registration

Strain: iP/Iusm

Symbol: iP/Iusm
Strain: iP
Substrain: Iusm
Full Name: inbred alcohol-preferring
RGD ID: 634380
Citation ID: RRID:RGD_634380
Ontology ID: RS:0000635
Alleles: Npy
Also Known As: P; alcohol-preferring; inbred alcohol-preferring
Type: inbred
Available Source: Not Available
Origination: Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana
Description: These were inbred alcohol-preferring rats developed from outbred alcohol-preferring rats (Iusm:P) at generation 30 at Indiana University for high-alcohol-preferring behavior. Inbred rats utilized for the development of alcohol-preferring, alcohol-nonpreferring congenic strains were in the27th generation of inbreeding.
Last Known Status: Unknown





References

References - curated
# Reference Title Reference Citation
1. Genomic screen for QTLs underlying alcohol consumption in the P and NP rat lines. Bice P, etal., Mamm Genome 1998 Dec;9(12):949-55.
2. A quantitative trait locus for alcohol consumption in selectively bred rat lines. Carr LG, etal., Alcohol Clin Exp Res 1998 Jun;22(4):884-7
3. Mapping of QTL influencing saccharin consumption in the selectively bred alcohol-preferring and -nonpreferring rat lines. Foroud T, etal., Behav Genet 2002 Jan;32(1):57-67.
4. Further genetic characterization of the fawn-hooded (FH/Wjd) rat, an animal model of comorbid depression and alcoholism. Rezvani AH, etal., Psychiatr Genet. 2007 Apr;17(2):77-83.
5. RGD Strain RSO annotation pipeline RGD Automated Pipelines
6. Effect of polymorphism on expression of the neuropeptide Y gene in inbred alcohol-preferring and -nonpreferring rats. Spence JP, etal., Neuroscience 2005;131(4):871-6.
7. Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats. Worst TJ, etal., J Neurosci Res 2005 May 15;80(4):529-38.

Region

Strain QTL Data
Symbol Name Trait
Alc18 Alcohol consumption QTL 18 drinking behavior trait   (VT:0001422)    
Alc19 Alcohol consumption QTL 19 drinking behavior trait   (VT:0001422)    
Alc20 Alcohol consumption QTL 20 drinking behavior trait   (VT:0001422)    
Alc21 Alcohol consumption QTL 21 drinking behavior trait   (VT:0001422)    
Alc8 Alcohol consumption QTL 8 consumption behavior trait   (VT:0002069)    
Sach1 Saccharin preference QTL 1 consumption behavior trait   (VT:0002069)    
Sach2 Saccharin preference QTL 2 consumption behavior trait   (VT:0002069)    
Sach3 Saccharin preference QTL 3 consumption behavior trait   (VT:0002069)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics These have high voluntary oral consumption of alcohol which leads to high blood alcohol. 69704
strain_other strain lacks a polymorphism in Npy gene at position +4666; associated with reduced mRNA levels in this strain 1357412
strain_phys_biochem Vamp2 mRNA is upregulated in frontal cortex compared to NP strain 1358772

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-05-01 iP/Iusm  inbred alcohol-preferring  P  alcohol-preferring  Symbol and/or name change 68913 APPROVED