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Strain Registration

Strain: F344.GK-(D1Mgh10-D1Rat119)/Swe

Symbol: F344.GK-(D1Mgh10-D1Rat119)/Swe
Strain: F344.GK-(D1Mgh10-D1Rat119)
Substrain: Swe
RGD ID: 634370
Citation ID: RRID:RGD_634370
Ontology ID: RS:0000281
Also Known As: F344.GK-(D1Mgh10-D1Rat119); F344-GK-Niddm1b; F344.GK-(D1Mgh10-D1Rat119)/Swe
Type: congenic
Available Source: Not Available
Origination: Karolinska Institute
Description: GK rats, containing a region for susceptibility to development of type 2 diabetes between D1Mgh10-D1Rat110 on chromosome 1 were mated with normoglycemic F344 rats. Progeny were backcrossd onto F344 for 10 generations. Heterozygous animals were intercrossed to establish the congenic strain.
Inbred Generations: F10
Last Known Status: Unknown
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21199,050,459 - 236,036,450RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01217,054,291 - 256,949,019RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01223,910,550 - 264,429,516RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41204,280,278 - 242,586,311RGD_MAPPER_PIPELINERGSC3.4





References

References - curated
# Reference Title Reference Citation
1. Pathophysiological and genetic characterization of the major diabetes locus in GK rats. Galli J, etal., Diabetes 1999 Dec;48(12):2463-70.
2. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Position Markers

Flank 1 / 1 (D1Mgh10)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21199,050,459 - 199,050,587 (+)MAPPER
Rnor_6.01217,054,291 - 217,054,418NCBI
Rnor_5.01223,910,550 - 223,910,677UniSTS
RGSC_v3.41204,280,278 - 204,280,406RGD
RGSC_v3.41204,280,279 - 204,280,406UniSTS
RGSC_v3.11204,433,664 - 204,433,956RGD
Celera1196,613,223 - 196,613,350UniSTS
RH 2.0 Map11099.1RGD

Flank 2 / 1 (D1Rat119)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21236,036,277 - 236,036,450 (+)MAPPER
Rnor_6.01256,948,847 - 256,949,019NCBI
Rnor_5.01264,429,344 - 264,429,516UniSTS
RGSC_v3.41242,586,138 - 242,586,311RGD
RGSC_v3.41242,586,139 - 242,586,311UniSTS
RGSC_v3.11242,802,464 - 242,802,636RGD
Celera1233,129,555 - 233,129,727UniSTS
RH 3.4 Map11580.8RGD
RH 3.4 Map11580.8UniSTS
RH 2.0 Map1619.1RGD
FHH x ACI Map1125.8199RGD
Cytogenetic Map1q53UniSTS
Strain QTL Data
Symbol Name Trait
Niddm44 Non-insulin dependent diabetes mellitus QTL 44 blood glucose amount   (VT:0000188)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics The adipose tissue from these rats display postprandial hyperglycemia and reduced insulin action. 619677