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Strain: LEW/Rj

Symbol: LEW/Rj
Strain: LEW
Substrain: Rj
RGD ID: 631593
Citation ID: RRID:RGD_631593
Ontology ID: RS:0000528
Type: inbred
Source: Hopital Purpan, Toulouse Cedex, France
Origin: Strain first obtained in 1987 from the Centre de Selection et d’Elevage d’Animaux de Laboratoire (CSEAL, Orl´eans, bred at Janvier breeding centre (Le Genest-Saint-Isle, France).
Last Known Status: Unknown

Experimental Data Annotations    Click to see Annotation Detail View

Rat Strain
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
LEW/Rj  IEA 7241799 RGD 

Vertebrate Trait
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
blood anti-double stranded DNA antibody amount  EXP 619646 RGD 
blood immunoglobulin E amount  EXP 619646 RGD 
brain integrity trait  EXP 1578521 RGD 
CD8-positive T cell quantity  EXP 1302824 RGD 


References - curated
# Reference Title Reference Citation
1. The rat Toxo1 locus directs toxoplasmosis outcome and controls parasite proliferation and spreading by macrophage-dependent mechanisms. Cavailles P, etal., Proc Natl Acad Sci U S A. 2006 Jan 17;103(3):744-9. Epub 2006 Jan 6.
2. A role for VAV1 in experimental autoimmune encephalomyelitis and multiple sclerosis. Jagodic M, etal., Sci Transl Med. 2009 Dec 9;1(10):10ra21. doi: 10.1126/scitranslmed.3000278.
3. Rat chromosome 9 bears a major susceptibility locus for IgE response. Mas M, etal., Eur J Immunol 2000 Jun;30(6):1698-705.
4. RGD Strain RSO annotation pipeline RGD Automated Pipelines
5. Functional and genetic analysis of two CD8 T cell subsets defined by the level of CD45RC expression in the rat. Xystrakis E, etal., J Immunol 2004 Sep 1;173(5):3140-7.


Strain QTL Data
Symbol Name Trait
Cdexp1 CD45RC expression in CD8 T cells QTL 1 CD8-positive T cell quantity   (VT:0008077)    
Cdexp2 CD45RC expression in CD8 T cells QTL 2 CD8-positive T cell quantity   (VT:0008077)    
Iresp1 Immunoglobin response QTL1 blood anti-double stranded DNA antibody amount   (VT:0004762)    
Iresp3 Immunoglobin response QTL3 blood immunoglobulin E amount   (VT:0002492)    
Toxo1 Toxoplasma gondii resistance QTL 1 brain integrity trait   (VT:0010579)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_immunology resistant to an immune response following injection with gold salts 619646

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-03-06 LEW/Rj    LEW/Rj    Name updated 68913 APPROVED
2013-03-06 LEW/Rj    LEW/Rj    Name updated 68913 APPROVED