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Strain: SBN/Ygl

Symbol: SBN/Ygl
Strain: SBN/Ygl
Substrain: Ygl
Full Name: Sabra hypertension resistant
RGD ID: 631573
Citation ID: RRID:RGD_631573
Ontology ID: RS:0000679
Previously known as: MDC-01-87
Type: inbred
Source: Ben Gurion University Barzilai Medical Center, Ashkelon, Israel
Origin: Bred from the original SBN colony established by Ben-Ishay at the Hebrew University Medical Center in Jerusalem. The original colony had been bred for 20+ generations but was found to be partly outbred and display phenotypic variability. To purify the colony and establish phenotypic homogeneity breeding pairs from the original colony were transferred to Ben Gurion University Barzilai Medical Center in Ashkelon, Israel in 1992 where renewed secondary breeding was performed.
Inbred Generations: F14+
Last Known Status: Unknown





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Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. RGD Strain RSO annotation pipeline RGD Automated Pipelines
2. SNP and haplotype mapping for genetic analysis in the rat. Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
3. Role of chromosome X in the Sabra rat model of salt-sensitive hypertension. Yagil C, etal., Hypertension 1999 Jan;33(1 Pt 2):261-5.
4. Development, genotype and phenotype of a new colony of the Sabra hypertension prone (SBH/y) and resistant (SBN/y) rat model of slat sensitivity and resistance. Yagil C, etal., J Hypertens 1996 Oct;14(10):1175-82.
5. Proteinuria and glomerulosclerosis in the Sabra genetic rat model of salt susceptibility. Yagil C, etal., Physiol Genomics 2002;9(3):167-78.
6. Genetic dissection of proteinuria in the Sabra rat. Yagil C, etal., Physiol Genomics. 2006 Mar 13;25(1):121-33. Epub 2006 Jan 3.
7. Geno-transcriptomic dissection of proteinuria in the uninephrectomized rat uncovers a molecular complexity with sexual dimorphism. Yagil Y, etal., Physiol Genomics. 2010 Nov 29;42A(4):301-16. Epub 2010 Sep 28.
8. Unmasking of proteinuria in the course of genetic dissection of nonproteinuric diabetic nephropathy. Yagil Y, etal., Physiol Genomics. 2014 Jan 1;46(1):29-38. doi: 10.1152/physiolgenomics.00133.2013. Epub 2013 Nov 5.

Region

Strain QTL Data
Symbol Name Trait
Bp56 Blood pressure QTL 56 arterial blood pressure trait   (VT:2000000)    
Bp64 Blood pressure QTL 64 arterial blood pressure trait   (VT:2000000)    
Bp65 Blood pressure QTL 65 arterial blood pressure trait   (VT:2000000)    
Bp96 Blood pressure QTL 96 arterial blood pressure trait   (VT:2000000)    
Bp97 Blood pressure QTL 97 arterial blood pressure trait   (VT:2000000)    
Bp98 Blood pressure QTL 98 arterial blood pressure trait   (VT:2000000)    
Kidm43 Kidney mass QTL 43 kidney mass   (VT:0002707)    
Niddm71 Non-insulin dependent diabetes mellitus QTL 71 blood glucose amount   (VT:0000188)    
Niddm72 Non-insulin dependent diabetes mellitus QTL 72 blood glucose amount   (VT:0000188)    
Pur12 Proteinuria QTL 12 total urine protein amount   (VT:0000032)    
Pur13 Proteinuria QTL 13 total urine protein amount   (VT:0000032)    
Pur14 Proteinuria QTL 14 total urine protein amount   (VT:0000032)    
Pur15 Proteinuria QTL 15 total urine protein amount   (VT:0000032)    
Pur24 Proteinuria QTL 24 total urine protein amount   (VT:0000032)    
Pur25 Proteinuria QTL 25 total urine protein amount   (VT:0000032)    
Pur26 Proteinuria QTL 26 total urine protein amount   (VT:0000032)    
Pur27 Proteinuria QTL 27 total urine protein amount   (VT:0000032)    
Pur28 Proteinuria QTL 28 total urine protein amount   (VT:0000032)    
Pur29 Proteinuria QTL 29 total urine protein amount   (VT:0000032)    
Pur30 Proteinuria QTL 30 total urine protein amount   (VT:0000032)    
Pur32 Proteinuria QTL 32 total urine protein amount   (VT:0000032)    
Rf60 Renal function QTL 60 blood creatinine amount   (VT:0005328)    
Rf61 Renal function QTL 61 blood creatinine amount   (VT:0005328)    
Rf62 Renal function QTL 62 blood urea nitrogen amount   (VT:0005265)    
Rf63 Renal function QTL 63 blood urea nitrogen amount   (VT:0005265)    
Damaging Variants
Number of Damaging Variants
SampleRnor_6.0Rnor_5.0RGSC_v3.4
SBN/Ygl (ICL) 619
SBN/Ygl (MCW) 1314
SBN/Ygl (KNAW) 782
SBN/Ygl (MCW) 2681
SBN/Ygl (RGD) 1170


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_phys_biochem Baseline systolic BP of SBH/Ygl has been measured as 127 +/-1mmHg, no sex differences between male and female rats were observed. Do not develop systolic or diastolic hypertension following 4 weeks of salt loading. DBP averaged 73 +/- 1mmHg and remained virtually unchanged after the salt loading treatment. 625550
strain_phys_biochem resistant to development of proteinuria in comparison with SBH/Ygl 1578625