Strain Report - Rat Genome Database

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Strain: SBH/Ygl

Symbol: SBH/Ygl
Strain: SBH/Ygl
Substrain: Ygl
Full Name: Sabra hypertension prone
RGD ID: 631572
Citation ID: RRID:RGD_631572
Ontology ID: RS:0000677
Previously known as: MDC-01-86
Type: inbred
Source: Ben Gurion University Barzilai Medical Center, Ashkelon, Israel
Origin: Bred from the original SBH colony established by Ben-Ishay at the Hebrew University Medical Center in Jerusalem. The original colony was found to be partly outbred and display phenotypic variability. To purify the colony and establish phenotypic homogeneity breeding pairs from the original colony were transferred to Ben Gurion University Barzilai Medical Center in Ashkelon, Israel in 1992 where renewed secondary breeding was performed.
Inbred Generations: F14+
Last Known Status: Unknown





References

References - curated
# Reference Title Reference Citation
1. RGD Strain RSO annotation pipeline RGD Automated Pipelines
2. SNP and haplotype mapping for genetic analysis in the rat. Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
3. Salt susceptibility maps to chromosomes 1 and 17 with sex specificity in the Sabra rat model of hypertension. Yagil C, etal., Hypertension 1998 Jan;31(1):119-24.
4. Role of chromosome X in the Sabra rat model of salt-sensitive hypertension. Yagil C, etal., Hypertension 1999 Jan;33(1 Pt 2):261-5.
5. Development, genotype and phenotype of a new colony of the Sabra hypertension prone (SBH/y) and resistant (SBN/y) rat model of slat sensitivity and resistance. Yagil C, etal., J Hypertens 1996 Oct;14(10):1175-82.
6. Proteinuria and glomerulosclerosis in the Sabra genetic rat model of salt susceptibility. Yagil C, etal., Physiol Genomics 2002;9(3):167-78.
7. Genetic dissection of proteinuria in the Sabra rat. Yagil C, etal., Physiol Genomics. 2006 Mar 13;25(1):121-33. Epub 2006 Jan 3.
8. Geno-transcriptomic dissection of proteinuria in the uninephrectomized rat uncovers a molecular complexity with sexual dimorphism. Yagil Y, etal., Physiol Genomics. 2010 Nov 29;42A(4):301-16. Epub 2010 Sep 28.

Region

Strain QTL Data
Symbol Name Trait
Bp56 Blood pressure QTL 56 arterial blood pressure trait   (VT:2000000)    
Bp64 Blood pressure QTL 64 arterial blood pressure trait   (VT:2000000)    
Bp65 Blood pressure QTL 65 arterial blood pressure trait   (VT:2000000)    
Bp96 Blood pressure QTL 96 arterial blood pressure trait   (VT:2000000)    
Bp97 Blood pressure QTL 97 arterial blood pressure trait   (VT:2000000)    
Bp98 Blood pressure QTL 98 arterial blood pressure trait   (VT:2000000)    
Pur12 Proteinuria QTL 12 urine total protein amount   (VT:0000032)    
Pur13 Proteinuria QTL 13 urine total protein amount   (VT:0000032)    
Pur14 Proteinuria QTL 14 urine total protein amount   (VT:0000032)    
Pur15 Proteinuria QTL 15 urine total protein amount   (VT:0000032)    
Pur24 Proteinuria QTL 24 urine total protein amount   (VT:0000032)    
Pur25 Proteinuria QTL 25 urine total protein amount   (VT:0000032)    
Pur26 Proteinuria QTL 26 urine total protein amount   (VT:0000032)    
Pur27 Proteinuria QTL 27 urine total protein amount   (VT:0000032)    
Pur28 Proteinuria QTL 28 urine total protein amount   (VT:0000032)    
Pur29 Proteinuria QTL 29 urine total protein amount   (VT:0000032)    
Pur30 Proteinuria QTL 30 urine total protein amount   (VT:0000032)    
Damaging Variants
Number of Damaging Variants
SampleRnor_6.0Rnor_5.0RGSC_v3.4
SBH/Ygl (ICL) 664
SBH/Ygl (MCW) 1352
SBH/Ygl (KNAW) 833
SBH/Ygl (MCW) 3000
SBH/Ygl (RGD) 1249


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_phys_biochem Baseline systolic BP of SBH/Ygl has been measured as 139+/-1mmHg, no sex differences between male and female rats were observed. SBP rises to 192 +/-2 mmHg following 4 weeks of salt loading with DOCA-salt. Develop diastolic hypertension, DBP rising from baseline of 88 +/-1mmHg to around 125mmHg following 4 weeks of salt loading. 625550
strain_phys_biochem prone to development of proteinuria in comparison to relatively resistant strain SBN/Ygl 1578625