Strain Report - Rat Genome Database
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Strain: SBH/Ygl

Symbol: SBH/Ygl
Strain: SBH/Ygl
Substrain: Ygl
Full Name: Sabra hypertension prone
RGD ID: 631572
RRID: RGD_631572
Ontology ID: RS:0000677
Also known as: MDC-01-86
Type: inbred
Source: Ben Gurion University Barzilai Medical Center, Ashkelon, Israel
Origin: Bred from the original SBH colony established by Ben-Ishay at the Hebrew University Medical Center in Jerusalem. The original colony was found to be partly outbred and display phenotypic variability. To purify the colony and establish phenotypic homogeneity breeding pairs from the original colony were transferred to Ben Gurion University Barzilai Medical Center in Ashkelon, Israel in 1992 where renewed secondary breeding was performed.
Inbred Generations: F14+
Last Known Status: Unknown





References


Region

Strain QTL Data
Symbol Name Trait
Bp56 Blood pressure QTL 56 arterial blood pressure trait   (VT:2000000)    
Bp64 Blood pressure QTL 64 arterial blood pressure trait   (VT:2000000)    
Bp65 Blood pressure QTL 65 arterial blood pressure trait   (VT:2000000)    
Bp96 Blood pressure QTL 96 arterial blood pressure trait   (VT:2000000)    
Bp97 Blood pressure QTL 97 arterial blood pressure trait   (VT:2000000)    
Bp98 Blood pressure QTL 98 arterial blood pressure trait   (VT:2000000)    
Pur12 Proteinuria QTL 12 total urine protein amount   (VT:0000032)    
Pur13 Proteinuria QTL 13 total urine protein amount   (VT:0000032)    
Pur14 Proteinuria QTL 14 total urine protein amount   (VT:0000032)    
Pur15 Proteinuria QTL 15 total urine protein amount   (VT:0000032)    
Pur24 Proteinuria QTL 24 total urine protein amount   (VT:0000032)    
Pur25 Proteinuria QTL 25 total urine protein amount   (VT:0000032)    
Pur26 Proteinuria QTL 26 total urine protein amount   (VT:0000032)    
Pur27 Proteinuria QTL 27 total urine protein amount   (VT:0000032)    
Pur28 Proteinuria QTL 28 total urine protein amount   (VT:0000032)    
Pur29 Proteinuria QTL 29 total urine protein amount   (VT:0000032)    
Pur30 Proteinuria QTL 30 total urine protein amount   (VT:0000032)    
Damaging Variants
Number of Damaging Variants
SampleRnor_6.0Rnor_5.0RGSC_v3.4
SBH/Ygl (ICL) 666
SBH/Ygl (MCW) 1330
SBH/Ygl (KNAW) 824
SBH/Ygl (MCW) 2179
SBH/Ygl (RGD) 1204


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_phys_biochem Baseline systolic BP of SBH/Ygl has been measured as 139+/-1mmHg, no sex differences between male and female rats were observed. SBP rises to 192 +/-2 mmHg following 4 weeks of salt loading with DOCA-salt. Develop diastolic hypertension, DBP rising from baseline of 88 +/-1mmHg to around 125mmHg following 4 weeks of salt loading. 625550
strain_phys_biochem prone to development of proteinuria in comparison to relatively resistant strain SBN/Ygl 1578625