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Strain Registration

Strain: WKY.SHRSP-(D2Mit5-D2Mgh12)/Gcrc

Symbol: WKY.SHRSP-(D2Mit5-D2Mgh12)/Gcrc
Strain: WKY.SHRSP-(D2Mit5-D2Mgh12)
Substrain: Gcrc
RGD ID: 631280
Citation ID: RRID:RGD_631280
Ontology ID: RS:0001059
Also Known As: WKY.SHRSP-(D2Mit5-D2Mgh12)/Gcrc; WKY.SPGla2c; WKY/Gla.SHRSP/Gla-(D2Mit5-D2Mgh12)/Gla
Type: congenic
Available Source: Not Available
Origination: University of Glasgow, Western Infirmary, Glasgow, UK
Description: Congenic strain created by introgressing the D2Mit5-D2Mgh12 region from Chromosome 2 of SHRSP/Gcrc into the WKY/Gcrc background in the lab of Dr Anna Dominiczak, University of Glasgow.
Last Known Status: Unknown
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2266,118,275 - 174,551,863RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0266,828,049 - 188,458,034RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0286,560,119 - 207,874,394RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4266,680,022 - 181,223,505RGD_MAPPER_PIPELINERGSC3.4





Disease Annotations     Click to see Annotation Detail View
hypertension  (IAGP)

Phenotype Annotations     Click to see Annotation Detail View

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table


References

References - curated
# Reference Title Reference Citation
1. Chromosome 2 reciprocal congenic strains to evaluate the effect of the genetic background on blood pressure. Carr FJ, etal., Scott Med J 2002 Feb;47(1):7-9.
2. Applicability of a "speed" congenic strategy to dissect blood pressure quantitative trait loci on rat chromosome 2. Jeffs B, etal., Hypertension 2000 Jan;35(1 Pt 2):179-87.
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Position Markers

Flank 1 / 1 (D2Mit5)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2266,118,275 - 66,118,463 (+)MAPPER
Rnor_6.0266,828,049 - 66,828,236NCBI
Rnor_5.0286,560,119 - 86,560,306UniSTS
RGSC_v3.4266,680,022 - 66,680,209UniSTS
Celera262,015,680 - 62,015,867UniSTS
RH 3.4 Map2421.0UniSTS
RH 3.4 Map2421.0RGD
RH 2.0 Map2375.6RGD
SHRSP x BN Map229.7698RGD

Flank 2 / 1 (Pklr)
Rat AssemblyChrPosition (strand)Source
GRCr82176,840,779 - 176,849,637 (+)NCBI
mRatBN7.22174,543,008 - 174,551,863 (+)NCBI
mRatBN7.2 Ensembl2174,543,039 - 174,551,870 (+)Ensembl
UTH_Rnor_SHR_Utx2181,689,431 - 181,697,810 (+)NCBI
UTH_Rnor_SHRSP_BbbUtx_1.02179,711,798 - 179,720,184 (+)NCBI
UTH_Rnor_WKY_Bbb_1.02174,311,737 - 174,320,129 (+)NCBI
Rnor_6.02188,449,158 - 188,458,034 (+)NCBI
Rnor_6.0 Ensembl2188,449,210 - 188,459,592 (+)Ensembl
Rnor_5.02207,865,529 - 207,874,394 (+)NCBI
RGSC_v3.42181,214,853 - 181,223,505 (+)NCBI
RGSC_v3.12181,164,961 - 181,173,618 (+)NCBI
Celera2168,486,468 - 168,494,841 (+)NCBI
RH 3.4 Map21154.4RGD
Cytogenetic Map2q34NCBI
Strain QTL Data
Symbol Name Trait
Bp163 Blood pressure QTL 163 arterial blood pressure trait   (VT:2000000)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_phys_biochem Baseline systolic blood pressure significantly higher than parental WKY/Gcrc strain, though magnitude of difference much less than that observed for SHRSP/Gcrc.WKY/Gcrc-(Fst-D2Mit5)/Gcrc congenic strain 68910