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Strain: DA/BklArbN

Symbol: DA/BklArbN
Strain: DA
Substrain: BklArbN
RGD ID: 631182
Citation ID: RRID:RRRC_00091
Ontology ID: RS:0001226
Type: inbred
Source: NIH, Arthritis and Rheumatism Branch, Bethesda MD
Origin: This is maintained in the NIH animal facility of the Inflammatory Joint Diseases Section, Arthritis and Rheumatism Branch, Bethesda MD by brother and sister breeding.
Last Known Status: Extinct





Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. Genetic dissection of collagen-induced arthritis in Chromosome 10 quantitative trait locus speed congenic rats: evidence for more than one regulatory locus and sex influences. Joe B, etal., Immunogenetics 2000 Sep;51(11):930-44.
2. Identification of Two Novel Female-Specific Non-MHC Loci Regulating Collagen-Induced Arthritis Severity and Chronicity, and Evidence for Epistasis. Meng HC,etal., Arthritis Rheum. 2004 Aug;50(8):2695-705.
3. Data registered by the Rat Resource & Research Center Personal Communication with Rat Resource & Research Center
4. Modulation of multiple experimental arthritis models by collagen-induced arthritis quantitative trait loci isolated in congenic rat lines: different effects of non-major histocompatibility complex quantitative trait loci in males and females. Remmers EF, etal., Arthritis Rheum 2002 Aug;46(8):2225-34.
5. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Strain QTL Data
Symbol Name Trait
Cia20 Collagen induced arthritis QTL 20 joint integrity trait   (VT:0010548)    
Cia21 Collagen induced arthritis QTL 21 joint integrity trait   (VT:0010548)    
Cia22 Collagen induced arthritis QTL 22 joint integrity trait   (VT:0010548)    
Cia23 Collagen induced arthritis QTL 23 joint integrity trait   (VT:0010548)    
Cia25 Collagen induced arthritis QTL 25 joint integrity trait   (VT:0010548)    
Cia26 Collagen induced arthritis QTL 26 joint integrity trait   (VT:0010548)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_other DA/BklArb rats have A allele and ACI/SegHsd have a G allele at nucleotide 316 (codon 106) and DA/BklArb rats have T allele and ACI/SegHsd have a C allele at nucleotide 458 (codon 153) that cause amino acid change which is responsible for arthritis-susceptible and resistant SNPs that correlated with variable production of reactive oxygen species 1285224

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-04-03 DA/BklArbN    DA/BklArbN    Name updated 68913 APPROVED
2013-04-15 DA/BklArbN    DA/BklArbN    Name updated 68913 APPROVED
2012-04-06 DA/BklArbN    DA/BklArbN    Name updated 68913 APPROVED
2012-04-06 DA/BklArbN    DA/BklArbN    Name updated 68913 APPROVED

Database Acc Id Source(s)
RRRC RRRC:0091 RGD