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Strain Registration

Strain: FHH/EurMcwi

Symbol: FHH/EurMcwi
Strain: FHH
Substrain: EurMcwi
RGD ID: 629509
RRID: RGD_629509
Ontology ID: RS:0000342
Also known as: MDC-03-07
Type: inbred
Source: PhysGen, Rat Resource and Research Center
Origin: An outbred stock of fawn hooded rats introduced into Europe by Tschopp in the early 1970s. Maintained as an outbred stock until the mid-1980s, then brother x sister mating initiated by A.P. Provoost to produce two strains designated FHH (also known as FHR) and FHL, which differ in hypertension and proteinuria. The colony was transferred to Erasmus University.
Coat Color: Fawn hood
Last Known Status: Live Animals; Cryorecovery





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Clinical Measurement
heart rate
left ventricular diastolic blood pressure
left ventricular systolic blood pressure
mean arterial blood pressure
body weight
body temperature
left ventricular developed pressure
red blood cell count
blood hemoglobin level
blood neutrophil count
blood lymphocyte count
blood monocyte count
blood eosinophil count
hematocrit
mean corpuscular volume
blood urea nitrogen level
plasma anion gap
heart wet weight
heart left ventricle wet weight
heart right ventricle wet weight
heart weight to body weight ratio
body length, nose to tail
left kidney wet weight
lung dry weight to body weight ratio
heart right ventricle weight to left ventricle weight ratio
plasma renin activity level
minute ventilation (VE)
arterial blood flow rate
tidal volume
timed urine volume
partial pressure of blood carbon dioxide (Pco2)
percent change in ventilation
respiration rate
mean corpuscular hemoglobin level
mean corpuscular hemoglobin concentration
absolute change in partial pressure of blood carbon dioxide
absolute change in partial pressure of blood oxygen
absolute change in blood pH
both kidneys wet weight to body weight ratio
serum triglyceride level
serum total cholesterol level
total white blood cell count
total serum bilirubin level
blood pH
partial pressure of blood oxygen
serum bicarbonate level
serum chloride level
serum potassium level
serum sodium level
serum calcium level
percent change in respiration rate
percent change in tidal volume
absolute change in mean arterial blood pressure
absolute change in heart rate
plasma creatinine level
serum phosphate level
serum glucose level
serum albumin level
serum alanine aminotransferase activity level
serum alkaline phosphatase activity level
serum aspartate aminotransferase activity level
serum urea nitrogen level
absolute change in plasma renin activity level
liver weight to body weight ratio
serum total protein level
time to onset of heart contraction
time to peak heart contraction
heart contraction pressure
heart left ventricle infarction weight to total heart left ventricle weight ratio
absolute change in body temperature
calculated pulmonary vascular resistance normalized to body weight
FAPGG metabolism-surface area product
methylene blue metabolism-surface area product without auto-oxidation
methylene blue metabolism-surface area product after auto-oxidation
methylene blue to FAPGG metabolism-surface area product ratio
dose of methacholine at which pulmonary conductance is half its pretreatment value (ED50)
fractional change in blood vessel diameter per unit change in intravascular pressure
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50)
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50)
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)
concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)
maximum contractile force per wet weight of aorta
acetylcholine-induced blood vessel dilation expressed as percent of force at maximum constriction
sodium nitroprusside-induced blood vessel dilation expressed as percent of force at maximum constriction
hypoxia-induced blood vessel dilation expressed as percent of force at maximum constriction
water drink intake rate
percent change in heart rate
percent change in arterial blood flow rate
percent change in left ventricular developed pressure
percent change in left ventricular systolic blood pressure
urine total protein excretion rate
urine albumin excretion rate
urine sodium excretion rate
urine potassium excretion rate
creatinine clearance
heart effluent lactate dehydrogenase activity level normalized to heart weight
renal blood flow rate
ratio of change in renal blood flow to change in renal perfusion pressure
urine albumin excretion rate to body weight ratio
creatinine clearance to total kidney weight ratio
serum globulin level

References


Region

Strain QTL Data
Symbol Name Trait
Rf55 Renal function QTL 55 renal blood flow trait   (VT:2000006)    
Damaging Variants
Number of Damaging Variants
SampleRnor_6.0Rnor_5.0RGSC_v3.4
FHH/EurMcwi (MDC) 743
FHH/EurMcwi (MCW) 1170
FHH/EurMcwi (ICL) 672
FHH/EurMcwi (MCW) 1477
FHH/EurMcwi (KNAW) 812
FHH/EurMcwi (MCW) 2121
FHH/EurMcwi (RGD) 999

Rat Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type
rs106411696 chr1 242400065 242400065 G A sequence_variant
rs105487995 chr1 224399836 224399836 T G sequence_variant
rgdv393055223 chr1 249700115 249700115 G A sequence_variant
rs105373896 chr1 252800388 252800388 G A sequence_variant
rs105278863 chr1 261199574 261199574 C T sequence_variant

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_drgs_chems L-NAME along with unilateral nephrectomy causes increase in blood pressure that is dose dependent. F1 rats develop severe hypertension, more functional and structural renal damage with increase in systolic blood pressure. 1357424
strain_drgs_chems L-NAME (N-nitro-L-arginine methyl ester) induces hypertension that can be prevented by lisinopril (LIS) which can prevent the development of functional and structural renal damage. 1357424
strain_life_disease These carry several genes which make them susceptible to renal damage. 1357424
strain_life_disease The blood pressure of females is 129 mmHg and of males is 131 mmHg. 629526
strain_other The average weight of females is 202g and of males 303g. 629526
strain_reproduction The average litter size is 8.5 pups and the generation time is 41 days. 629526

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-12 FHH/EurMcwi    FHH/EurMcwi    Name updated 68913 APPROVED
2013-08-12 FHH/EurMcwi    FHH/EurMcwi    Name updated 68913 APPROVED