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Strain Registration

Strain: FHH/EurMcwi

Symbol: FHH/EurMcwi
Strain: FHH
Substrain: EurMcwi
RGD ID: 629509
Citation ID: RRID:RRRC_00293
Ontology ID: RS:0000342
Previously known as: MDC-03-07
Type: inbred
Source: PhysGen, Rat Resource and Research Center
Origin: An outbred stock of fawn hooded rats introduced into Europe by Tschopp in the early 1970s. Maintained as an outbred stock until the mid-1980s, then brother x sister mating initiated by A.P. Provoost to produce two strains designated FHH (also known as FHR) and FHL, which differ in hypertension and proteinuria. The colony was transferred to Erasmus University.
Coat Color: Fawn hood
Last Known Status: Live Animals; Cryorecovery





Disease Annotations     Click to see Annotation Detail View
Albuminuria  (IAGP)
glomerulosclerosis  (IAGP)
proteinuria  (IAGP,IMP)

Phenotype Annotations     Click to see Annotation Detail View

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table

Clinical Measurement
heart rate
left ventricular diastolic blood pressure
left ventricular systolic blood pressure
mean arterial blood pressure
body weight
body temperature
left ventricular developed pressure
red blood cell count
blood hemoglobin level
blood neutrophil count
blood lymphocyte count
blood monocyte count
blood eosinophil count
hematocrit
mean corpuscular volume
blood urea nitrogen level
plasma anion gap
heart wet weight
heart left ventricle wet weight
heart right ventricle wet weight
heart weight to body weight ratio
body length, nose to tail
body length, nose to rump
left kidney wet weight
lung dry weight to body weight ratio
heart right ventricle weight to left ventricle weight ratio
plasma renin activity level
minute ventilation
arterial blood flow rate
tidal volume
timed urine volume
partial pressure of blood carbon dioxide (Pco2)
percent change in ventilation
respiration rate
mean corpuscular hemoglobin
mean corpuscular hemoglobin concentration
absolute change in partial pressure of blood carbon dioxide
absolute change in partial pressure of blood oxygen
absolute change in blood pH
both kidneys wet weight to body weight ratio
serum triglyceride level
serum total cholesterol level
total white blood cell count
serum total bilirubin level
blood pH
partial pressure of blood oxygen
serum bicarbonate level
serum chloride level
serum potassium level
serum sodium level
serum calcium level
percent change in respiration rate
percent change in tidal volume
absolute change in mean arterial blood pressure
absolute change in heart rate
plasma creatinine level
serum phosphate level
serum glucose level
serum albumin level
serum alanine aminotransferase activity level
serum alkaline phosphatase activity level
serum aspartate aminotransferase activity level
serum urea nitrogen level
liver weight to body weight ratio
serum total protein level
time to onset of heart contraction
time to peak heart contraction
heart contraction pressure
heart left ventricle infarction weight to total heart left ventricle weight ratio
absolute change in body temperature
calculated pulmonary vascular resistance normalized to body weight
FAPGG metabolism-surface area product
methylene blue metabolism-surface area product without auto-oxidation
methylene blue metabolism-surface area product after auto-oxidation
methylene blue to FAPGG metabolism-surface area product ratio
dose of methacholine at which pulmonary conductance is half its pretreatment value
fractional change in blood vessel diameter per unit change in intravascular pressure
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50)
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50)
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)
concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)
maximum contractile force per wet weight of aorta
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel
hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel
water drink intake rate
percent change in heart rate
percent change in arterial blood flow rate
percent change in left ventricular developed pressure
percent change in left ventricular systolic blood pressure
urine total protein excretion rate
urine albumin excretion rate
urine sodium excretion rate
urine potassium excretion rate
creatinine clearance
heart effluent lactate dehydrogenase activity level normalized to heart weight
renal blood flow rate
ratio of change in renal blood flow to change in renal perfusion pressure
urine albumin excretion rate to body weight ratio
creatinine clearance to total kidney weight ratio
serum globulin level

References

References - curated
# Reference Title Reference Citation
1. A Mutation in γ-Adducin Impairs Autoregulation of Renal Blood Flow and Promotes the Development of Kidney Disease. Fan F, etal., J Am Soc Nephrol. 2020 Apr;31(4):687-700. doi: 10.1681/ASN.2019080784. Epub 2020 Feb 6.
2. Identification of a QTL on chromosome 1 for impaired autoregulation of RBF in fawn-hooded hypertensive rats. Lopez B, etal., Am J Physiol Renal Physiol. 2006 May;290(5):F1213-21. Epub 2005 Nov 22.
3. Initial characterization of a rat model of diabetic nephropathy. Nobrega MA, etal., Diabetes 2004 Mar;53(3):735-42.
4. Role of genetic modifiers in an orthologous rat model of ARPKD. O'Meara CC, etal., Physiol Genomics. 2012 Aug 1;44(15):741-53. doi: 10.1152/physiolgenomics.00187.2011. Epub 2012 Jun 5.
5. PhysGen Strains PhysGen strains
6. RF-2 gene modulates proteinuria and albuminuria independently of changes in glomerular permeability in the fawn-hooded hypertensive rat. Rangel-Filho A, etal., J Am Soc Nephrol 2005 Apr;16(4):852-6. Epub 2005 Mar 9.
7. Rab38 modulates proteinuria in model of hypertension-associated renal disease. Rangel-Filho A, etal., J Am Soc Nephrol. 2013 Feb;24(2):283-92. doi: 10.1681/ASN.2012090927. Epub 2013 Jan 4.
8. RGD Strain RSO annotation pipeline RGD Automated Pipelines
9. SNP and haplotype mapping for genetic analysis in the rat. Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
10. Impaired autoregulation of renal blood flow in the fawn-hooded rat. Van Dokkum RP, etal., Am J Physiol 1999 Jan;276(1 Pt 2):R189-96
11. Altered renal hemodynamics and impaired myogenic responses in the fawn-hooded rat. van Dokkum RP, etal., Am J Physiol 1999 Mar;276(3 Pt 2):R855-63
12. Blood pressure and the susceptibility to renal damage after unilateral nephrectomy and L-NAME-induced hypertension in rats. van Dokkum RP, etal., Nephrol Dial Transplant 2000 Sep;15(9):1337-43.

Region

Strain QTL Data
Symbol Name Trait
Rf55 Renal function QTL 55 renal blood flow trait   (VT:2000006)    
Damaging Variants
Number of Damaging Variants
SampleRnor_6.0Rnor_5.0RGSC_v3.4
FHH/EurMcwi (MDC) 743
FHH/EurMcwi (MCW) 1173
FHH/EurMcwi (ICL) 670
FHH/EurMcwi (MCW) 1500
FHH/EurMcwi (KNAW) 826
FHH/EurMcwi (MCW) 2921
FHH/EurMcwi (RGD) 1033
FHH/EurMcwi (2019) 3080
FHH/EurMcwi (2019)

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
rs106411696 chr1 242400065 242400065 G A sequence_variant RGSC_v3.4
rs105487995 chr1 224399836 224399836 T G sequence_variant RGSC_v3.4
rgdv393055223 chr1 249700115 249700115 G A sequence_variant RGSC_v3.4
rs105373896 chr1 252800388 252800388 G A sequence_variant RGSC_v3.4
rs105278863 chr1 261199574 261199574 C T sequence_variant RGSC_v3.4

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_drgs_chems L-NAME along with unilateral nephrectomy causes increase in blood pressure that is dose dependent. F1 rats develop severe hypertension, more functional and structural renal damage with increase in systolic blood pressure. 1357424
strain_drgs_chems L-NAME (N-nitro-L-arginine methyl ester) induces hypertension that can be prevented by lisinopril (LIS) which can prevent the development of functional and structural renal damage. 1357424
strain_life_disease These carry several genes which make them susceptible to renal damage. 1357424
strain_life_disease The blood pressure of females is 129 mmHg and of males is 131 mmHg. 629526
strain_other The average weight of females is 202g and of males 303g. 629526
strain_reproduction The average litter size is 8.5 pups and the generation time is 41 days. 629526

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-12 FHH/EurMcwi    FHH/EurMcwi    Name updated 68913 APPROVED
2013-08-12 FHH/EurMcwi    FHH/EurMcwi    Name updated 68913 APPROVED

Database Acc Id Source(s)
RRRC RRRC:00293 RGD