Strain Report - Rat Genome Database

Name: FHH/EurMcwi
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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General

Strain: FHH/EurMcwi
Symbol:	FHH/EurMcwi
Strain:	FHH
Substrain:	EurMcwi
Ontology ID:	RS:0000342
Also known as:	MDC-03-07
Type:	inbred
Source:	PhysGen, Rat Resource and Research Center
Origin:	An outbred stock of fawn hooded rats introduced into Europe by Tschopp in the early 1970s. Maintained as an outbred stock until the mid-1980s, then brother x sister mating initiated by A.P. Provoost to produce two strains designated FHH (also known as FHR) and FHL, which differ in hypertension and proteinuria. The colony was transferred to Erasmus University.
Coat Color:	Fawn hood
Last Known Status:	Live Animals; Cryorecovery

Annotation (Toggle Annotation Detail/Summary View)

Disease Annotations

RGD Manual Annotations

Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Albuminuria		TAS		1357424		RGD
end stage renal failure		TAS		1579884		RGD
focal segmental glomerulosclerosis		TAS		1579884		RGD
focal segmental glomerulosclerosis		TAS		1357424		RGD
hypertension		IDA		1357424		RGD
proteinuria		TAS		61028		RGD
proteinuria		TAS		1579884		RGD

Phenotype Annotations

Mammalian Phenotype

Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
albuminuria		TAS		1357424		RGD
glomerulosclerosis		TAS		1357424		RGD
glomerulosclerosis		IDA		1579884		RGD
hypertension		IDA		1357424		RGD
increased renal glomerular filtration rate		TAS		61028		RGD
increased systemic arterial blood pressure		IDA		1357424		RGD
increased systemic arterial systolic blood pressure		IDA		1357424		RGD
increased urine protein level		IDA		1579884		RGD

Phenotype Values via Phenominer

Related Phenotype Data for Term "FHH/EurMcwi" (RS:0000342)

Rat Strains:

FHH/EurMcwi

Clinical Measurements:

absolute change in blood pH
absolute change in body temperature
absolute change in heart rate
absolute change in mean arterial blood pressure
absolute change in partial pressure of blood carbon dioxide
absolute change in partial pressure of blood oxygen
absolute change in plasma renin activity level
acetylcholine-induced blood vessel dilation expressed as percent of force at maximum constriction
arterial blood flow rate
blood eosinophil count
blood hemoglobin level
blood lymphocyte count
blood monocyte count
blood neutrophil count
blood pH
blood urea nitrogen level
body length, nose to rump
body length, nose to tail
body temperature
body weight
both kidneys wet weight to body weight ratio
calculated pulmonary vascular resistance normalized to body weight
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50)
concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)
creatinine clearance
creatinine clearance to total kidney weight ratio
dose of methacholine at which pulmonary conductance is half its pretreatment value (ED50)
FAPGG metabolism-surface area product
fractional change in blood vessel diameter per unit change in intravascular pressure
heart contraction pressure
heart effluent lactate dehydrogenase activity level normalized to heart weight
heart left ventricle infarction weight as percentage of total heart left ventricle weight
heart left ventricle wet weight
heart rate
heart right ventricle weight to left ventricle weight ratio
heart right ventricle wet weight
heart weight as percentage of body weight
heart weight to body weight ratio
heart wet weight
hematocrit
hypoxia-induced blood vessel dilation expressed as percent of force at maximum constriction
left kidney wet weight
left ventricular developed pressure
left ventricular diastolic blood pressure
left ventricular systolic blood pressure
liver weight to body weight ratio
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50)
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)
lung dry weight to body weight ratio
maximum contractile force per wet weight of aorta
mean arterial blood pressure
mean corpuscular hemoglobin concentration
mean corpuscular hemoglobin level
mean corpuscular volume
methylene blue metabolism-surface area product after auto-oxidation
methylene blue metabolism-surface area product without auto-oxidation
methylene blue to FAPGG metabolism-surface area product ratio
minute ventilation (VE)
partial pressure of blood carbon dioxide (Pco2)
partial pressure of blood oxygen (Po2)
percent change in arterial blood flow rate
percent change in heart rate
percent change in left ventricular developed pressure
percent change in left ventricular systolic blood pressure
percent change in respiration rate
percent change in tidal volume
percent change in ventilation
plasma anion gap
plasma creatinine level
plasma renin activity level
ratio of change in renal blood flow to change in renal perfusion pressure
red blood cell count
renal blood flow rate
respiration rate
serum alanine aminotransferase activity level
serum albumin level
serum alkaline phosphatase activity level
serum aspartate aminotransferase activity level
serum bicarbonate level
serum calcium level
serum chloride level
serum globulin level
serum glucose level
serum phosphate level
serum potassium level
serum sodium level
serum total cholesterol level
serum total protein level
serum triglyceride level
serum urea nitrogen level
sodium nitroprusside-induced blood vessel dilation expressed as percent of force at maximum constriction
tidal volume
time to onset of heart contraction
time to peak heart contraction
timed urine volume
total serum bilirubin level
total white blood cell count
urine albumin excretion rate
urine albumin excretion rate to body weight ratio
urine potassium excretion rate
urine sodium excretion rate
urine total protein excretion rate
water drink intake rate

Experimental Conditions:

acetylcholine
air carbon dioxide content
air oxygen content
angiotensin
controlled in situ renal perfusion pressure
controlled NG-nitroarginine methyl ester content drinking water
controlled oxygen content Kreb's solution perfusate
controlled oxygen content physiological salt solution perfusate
controlled sodium content diet
drug dose time series
FAPGG
fasting
furosemide
Kreb's solution perfusate
methacholine
methylene blue
naive control condition
norepinephrine
perfusate suspended
phenylephrine
potassium ion
resting on treadmill
running on treadmill
sample resting period
sodium nitroprusside
walking on treadmill

Measurement Methods:

automated blood analysis
automated blood cell counting method
automated blood gas analysis using a Bayer analyzer
automated plasma creatinine analysis
automated urine analysis
automated urine total protein analysis
balloon tipped catheter with pressure transducer in isolated perfused heart
body weighing method
digital rectal thermometry
digital scale post excision weight measurement
flame atomic emission spectrometry
fluid-filled catheter with pressure transducer in isolated perfused lung
graduated cylinder
in vivo ruler method
isolated perfused heart effluent collection
isolated perfused lung vascular effluent collection
microhematocrit tube assay with visual assessment
post excision weight measurement
radioimmunoassay
serum creatinine analysis
serum total cholesterol measurement test
serum triglyceride analysis
serum urea analysis
standard blood chemistry panel
stop flow air displacement plethysmography
ultrasonic flowmeter
urine albumin analysis
urine creatinine analysis
urine volume measurement method
vascular fluid filled catheter
vascular indwelling catheter method
whole body digital scale
wire myography using a Digi-Med tissue force analysis system with force transducer

Disease Annotations

	Albuminuria (TAS)
	end stage renal failure (TAS)

	focal segmental glomerulosclerosis (TAS)
	hypertension (IDA)

proteinuria (TAS)

Phenotype Annotations

Mammalian Phenotype

	albuminuria (TAS)
	glomerulosclerosis (IDA,TAS)
	hypertension (IDA)

	increased renal glomerular filtration rate (TAS)
	increased systemic arterial blood pressure (IDA)
	increased systemic arterial systolic blood pressure (IDA)

increased urine protein level (IDA)

Experimental Data Annotations

Rat Strain

FHH/EurMcwi (IEA)

Phenotype Values via Phenominer

Options:

View chart

Download data table

View expanded data table

Clinical Measurement

heart rate

left ventricular diastolic blood pressure

left ventricular systolic blood pressure

mean arterial blood pressure

body weight

body temperature

left ventricular developed pressure

red blood cell count

blood hemoglobin level

blood neutrophil count

blood lymphocyte count

blood monocyte count

blood eosinophil count

hematocrit

mean corpuscular volume

blood urea nitrogen level

plasma anion gap

heart wet weight

heart left ventricle wet weight

heart right ventricle wet weight

heart weight to body weight ratio

heart weight as percentage of body weight

body length, nose to tail

left kidney wet weight

lung dry weight to body weight ratio

heart right ventricle weight to left ventricle weight ratio

plasma renin activity level

minute ventilation (VE)

arterial blood flow rate

tidal volume

timed urine volume

partial pressure of blood carbon dioxide (Pco2)

percent change in ventilation

respiration rate

mean corpuscular hemoglobin level

mean corpuscular hemoglobin concentration

absolute change in partial pressure of blood carbon dioxide

absolute change in partial pressure of blood oxygen

absolute change in blood pH

both kidneys wet weight to body weight ratio

serum triglyceride level

serum total cholesterol level

total white blood cell count

total serum bilirubin level

blood pH

partial pressure of blood oxygen (Po2)

serum bicarbonate level

serum chloride level

serum potassium level

serum sodium level

serum calcium level

percent change in respiration rate

percent change in tidal volume

absolute change in mean arterial blood pressure

absolute change in heart rate

plasma creatinine level

serum phosphate level

serum glucose level

serum albumin level

serum alanine aminotransferase activity level

serum alkaline phosphatase activity level

serum aspartate aminotransferase activity level

serum urea nitrogen level

absolute change in plasma renin activity level

liver weight to body weight ratio

serum total protein level

time to onset of heart contraction

time to peak heart contraction

heart contraction pressure

heart left ventricle infarction weight as percentage of total heart left ventricle weight

absolute change in body temperature

calculated pulmonary vascular resistance normalized to body weight

FAPGG metabolism-surface area product

methylene blue metabolism-surface area product without auto-oxidation

methylene blue metabolism-surface area product after auto-oxidation

methylene blue to FAPGG metabolism-surface area product ratio

dose of methacholine at which pulmonary conductance is half its pretreatment value (ED50)

fractional change in blood vessel diameter per unit change in intravascular pressure

concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50)

logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50)

concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)

logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)

concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)

logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)

maximum contractile force per wet weight of aorta

acetylcholine-induced blood vessel dilation expressed as percent of force at maximum constriction

sodium nitroprusside-induced blood vessel dilation expressed as percent of force at maximum constriction

hypoxia-induced blood vessel dilation expressed as percent of force at maximum constriction

water drink intake rate

percent change in heart rate

percent change in arterial blood flow rate

percent change in left ventricular developed pressure

percent change in left ventricular systolic blood pressure

urine total protein excretion rate

urine albumin excretion rate

urine sodium excretion rate

urine potassium excretion rate

creatinine clearance

heart effluent lactate dehydrogenase activity level normalized to heart weight

renal blood flow rate

ratio of change in renal blood flow to change in renal perfusion pressure

urine albumin excretion rate to body weight ratio

creatinine clearance to total kidney weight ratio

serum globulin level

References - curated

1.	Lopez B, etal., Am J Physiol Renal Physiol. 2006 May;290(5):F1213-21. Epub 2005 Nov 22.
2.	O'Meara CC, etal., Physiol Genomics. 2012 Aug 1;44(15):741-53. doi: 10.1152/physiolgenomics.00187.2011. Epub 2012 Jun 5.
3.	PhysGen strains
4.	RGD Automated Pipelines
5.	Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
6.	Van Dokkum RP, etal., Am J Physiol 1999 Jan;276(1 Pt 2):R189-96
7.	van Dokkum RP, etal., Nephrol Dial Transplant 2000 Sep;15(9):1337-43.

RGD Disease Portals

FHH/EurMcwi has been annotated in the following RGD Disease Portals.

Aging/Age-Related Disease Phenotypes

Aging/Age-Related Diseases

Cardiovascular Diseases

Cardiovascular Phenotypes

Diabetes Diseases

Diabetes Phenotypes

Immune and Inflammatory Diseases

Obesity Diseases

Obesity Phenotypes

Renal Diseases

Renal Phenotypes

Region

Strain QTL Data

Symbol	Name	Trait
Rf55	Renal function QTL 55	renal blood flow trait (VT:2000006)

Damaging Variants

	Number of Damaging Variants
Sample	Rnor_6.0	Rnor_5.0	RGSC_v3.4
FHH/EurMcwi (MDC)			743
FHH/EurMcwi (MCW)			1170
FHH/EurMcwi (ICL)			672
FHH/EurMcwi (MCW)		1477
FHH/EurMcwi (KNAW)		812
FHH/EurMcwi (MCW)	2121
FHH/EurMcwi (RGD)	999

Additional Information

RGD Curation Notes

Note Type	Note	Reference
strain_drgs_chems	L-NAME along with unilateral nephrectomy causes increase in blood pressure that is dose dependent. F₁ rats develop severe hypertension, more functional and structural renal damage with increase in systolic blood pressure.	1357424
strain_drgs_chems	L-NAME (N-nitro-L-arginine methyl ester) induces hypertension that can be prevented by lisinopril (LIS) which can prevent the development of functional and structural renal damage.	1357424
strain_life_disease	These carry several genes which make them susceptible to renal damage.	1357424
strain_life_disease	The blood pressure of females is 129 mmHg and of males is 131 mmHg.	629526
strain_other	The average weight of females is 202g and of males 303g.	629526
strain_reproduction	The average litter size is 8.5 pups and the generation time is 41 days.	629526

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-08-12	FHH/EurMcwi		FHH/EurMcwi		Name updated	68913	APPROVED
2013-08-12	FHH/EurMcwi		FHH/EurMcwi		Name updated	68913	APPROVED

More on this Strain
	Strain Nomenclature
	Strain Registration

RGD Object Information
RGD ID:	629509
Created:	2003-05-16
Species:	Rattus norvegicus
Last Modified:	2004-10-15
Status:	ACTIVE

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.

Strain: FHH/EurMcwi

RGD Manual Annotations

Related Phenotype Data for Term "FHH/EurMcwi" (RS:0000342)