Strain Report - Rat Genome Database

Name: LE/Stm
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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General

Strain: LE/Stm
Symbol:	LE/Stm
Strain:	LE
Substrain:	Stm
Ontology ID:	RS:0000431
Also known as:	NBRP Rat No: 0139; MDC-02-14
Type:	inbred
Source:	National BioResource Project for the Rat in Japan
Origin:	The LE/Stm rats were introduced into Saitama Cancer Center Research Institute in 1969 from a closed colony of Long Evans rats maintained in the Ben May Laboratory for Cancer Research, University of Chicago. A mutant with red-eyed dilution was found in 1970 in the Long-Evans colony, and the mutation was fixed by selective mating. Thereafter, they were maintained by sister-brother mating more than F50.
Inbred Generations:	F50
Last Known Status:	Live Animals; Cryopreserved Sperm
Research Usage	Diabetes Obesity; Cancer

Annotation (Toggle Annotation Detail/Summary View)

Disease Annotations

RGD Manual Annotations

Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
leukemia		IDA		619600		RGD

Phenotype Annotations

Mammalian Phenotype

Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
increased leukemia incidence		IDA		619600		RGD

Phenotype Values via Phenominer

Related Phenotype Data for Term "LE/Stm" (RS:0000431)

Rat Strains:

LE/Stm

Clinical Measurements:

activated partial thromboplastin time
blood band neutrophil count to total leukocyte count ratio
blood basophil count to total leukocyte count ratio
blood eosinophil count to total leukocyte count ratio
blood hemoglobin level
blood lymphocyte count to total leukocyte count ratio
blood monocyte count to total leukocyte count ratio
blood segmented neutrophil count to total leukocyte count ratio
body temperature
body weight
both adrenal glands weight to body weight ratio
both adrenal glands wet weight
both kidneys wet weight
both kidneys wet weight as percentage of body weight
both testes wet weight
both testes wet weight to body weight ratio
brain weight to body weight ratio
brain wet weight
heart rate
heart weight as percentage of body weight
heart wet weight
hematocrit
liver weight as percentage of body weight
liver wet weight
lung weight to body weight ratio
lung wet weight
mean corpuscular hemoglobin concentration
mean corpuscular hemoglobin level
mean corpuscular volume
non-specified leukocyte count to total leukocyte count ratio
percentage of study population developing leukemia during a period of time
percentage of study population developing T-cell lymphomas during a period of time
plasma alanine aminotransferase activity level
plasma albumin level
plasma albumin to plasma total protein ratio
plasma alkaline phosphatase activity level
plasma aspartate aminotransferase activity level
plasma chloride level
plasma creatinine level
plasma glucose level
plasma high density lipoprotein cholesterol level
plasma low density lipoprotein cholesterol level
plasma phosphate level
plasma potassium level
plasma sodium level
plasma total cholesterol level
plasma total protein level
plasma triglyceride level
plasma urea nitrogen level
platelet count
post-insult time to onset of leukemia
post-insult time to onset of T-cell lymphoma
prothrombin time
red blood cell count
spleen weight to body weight ratio
spleen wet weight
systolic blood pressure
timed urine volume
timed urine volume to body weight ratio
total plasma bilirubin level
total plasma calcium level
urine chloride excretion rate to body weight ratio
urine chloride level
urine potassium excretion rate to body weight ratio
urine potassium level
urine sodium excretion rate to body weight ratio
urine sodium level
white blood cell count

Experimental Conditions:

0.9% sodium chloride solution
controlled N-propyl-N-nitrosourea content drinking water
diethylstilbestrol
fasting
naive control condition
specific pathogen-free conditions

Measurement Methods:

automated blood electrolyte analysis
automated cell/particle size/count analysis method
automated coagulometer method
automated differential white blood cell count test
automated plasma albumin analysis
automated plasma analysis
automated plasma creatinine analysis
automated plasma protein analysis
automated plasma total protein analysis
automated urine analysis
digital rectal thermometry
ex vivo light microscopy with immunohistochemistry
fluorescence-activated cell sorting method
metabolic cage urine volume measurement method
post excision weight measurement
Shimadzu electronic balance post excision weight measurement
tail cuff photoplethysmography
whole body digital scale

Disease Annotations

leukemia (IDA)

Phenotype Annotations

Mammalian Phenotype

increased leukemia incidence (IDA)

Experimental Data Annotations

Rat Strain

LE/Stm (IEA)

Phenotype Values via Phenominer

Options:

View chart

Download data table

View expanded data table

Clinical Measurement

heart rate

systolic blood pressure

body weight

body temperature

red blood cell count

blood hemoglobin level

white blood cell count

platelet count

hematocrit

mean corpuscular volume

plasma glucose level

plasma aspartate aminotransferase activity level

plasma alanine aminotransferase activity level

plasma alkaline phosphatase activity level

plasma total protein level

plasma albumin level

plasma phosphate level

plasma chloride level

plasma sodium level

plasma potassium level

heart wet weight

heart weight as percentage of body weight

both kidneys wet weight

lung wet weight

urine potassium level

urine sodium level

brain weight to body weight ratio

both kidneys wet weight as percentage of body weight

liver weight as percentage of body weight

spleen weight to body weight ratio

brain wet weight

lung weight to body weight ratio

liver wet weight

both adrenal glands wet weight

spleen wet weight

both testes wet weight

activated partial thromboplastin time

prothrombin time

timed urine volume

mean corpuscular hemoglobin level

mean corpuscular hemoglobin concentration

blood basophil count to total leukocyte count ratio

blood eosinophil count to total leukocyte count ratio

blood lymphocyte count to total leukocyte count ratio

blood monocyte count to total leukocyte count ratio

total plasma calcium level

urine chloride level

plasma creatinine level

plasma triglyceride level

plasma total cholesterol level

plasma urea nitrogen level

both adrenal glands weight to body weight ratio

plasma high density lipoprotein cholesterol level

plasma low density lipoprotein cholesterol level

both testes wet weight to body weight ratio

percentage of study population developing leukemia during a period of time

urine sodium excretion rate to body weight ratio

post-insult time to onset of leukemia

post-insult time to onset of T-cell lymphoma

percentage of study population developing T-cell lymphomas during a period of time

timed urine volume to body weight ratio

urine chloride excretion rate to body weight ratio

urine potassium excretion rate to body weight ratio

total plasma bilirubin level

blood segmented neutrophil count to total leukocyte count ratio

blood band neutrophil count to total leukocyte count ratio

non-specified leukocyte count to total leukocyte count ratio

plasma albumin to plasma total protein ratio

References - curated

1.	Hashimoto R, etal., Exp Anim. 2013;62(3):181-7.
2.	Lu LM, etal., Br J Cancer 1999 May;80(5-6):855-61.
3.	Mashimo T, etal., BMC Genet. 2006 Apr 4;7:19.
4.	Personal Communication with NBRP
5.	RGD Automated Pipelines
6.	Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
7.	Shisa H, etal., Mamm Genome 1997 May;8(5):324-7.

RGD Disease Portals

LE/Stm has been annotated in the following RGD Disease Portals.

Aging/Age-Related Disease Phenotypes

Cancer Diseases

Cancer Phenotypes

Hematologic Disease Phenotypes

Hematologic Diseases

Region

Damaging Variants

	Number of Damaging Variants
Sample	Rnor_6.0	Rnor_5.0	RGSC_v3.4
LE/Stm (KNAW)			543
LE/Stm (ICL)			665
LE/Stm (Illumina) (KNAW)		834
LE/Stm (SOLiD) (KNAW)		605
LE/Stm (KyushuU)		1305
LE/Stm (RGD)	1179

Additional Information

RGD Curation Notes

Note Type	Note	Reference
strain_other	A BAC library for this strain is available from the RIKEN BioResource Center.	2292911
strain_reproduction	Good breeding performance.	628402

Nomenclature History

Date	Current Symbol	Previous Symbol	Description	Reference	Status
2012-05-09	LE/Stm	LE/Stm	Name updated	68913	APPROVED
2012-05-09	LE/Stm	LE/Stm	Name updated	68913	APPROVED
2012-01-11	LE/Stm	LE/Stm	Name updated	68913	APPROVED
2012-01-11	LE/Stm	LE/Stm	Name updated	68913	APPROVED

More on this Strain
	Strain Nomenclature
	Strain Registration

RGD Object Information
RGD ID:	629485
Created:	2003-04-16
Species:	Rattus norvegicus
Last Modified:	2009-05-13
Status:	ACTIVE

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.

Strain: LE/Stm

RGD Manual Annotations

Related Phenotype Data for Term "LE/Stm" (RS:0000431)