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Strain: LETsc2Eker/Hin

Symbol: LETsc2Eker/Hin
Strain: LETsc2Eker
Substrain: Hin
RGD ID: 625624
Citation ID: RRID:RGD_625624
Ontology ID: RS:0000385
Alleles: Tsc2Eker;   Tsc2
Also Known As: Eker rat; Eker-Tsc2/Hin; LETsc2Eker/Hin; LETsc2^[Eker]/Hin
Type: mutant
Available Source: Not Available
Origination: Department of Experimental Pathology, Cancer Institute, Toshima-ku, Tokyo Japan
Description: Eker rat is derived from the Long-Evans strain that has a mutation in Tsc2 gene. Originally reported by R. Eker in 1954 at the Norwegian Radium Hospital, Oslo.
Last Known Status: Unknown
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81014,125,679 - 14,160,317RGD_MAPPER_PIPELINE
mRatBN7.21013,621,135 - 13,655,773RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01013,962,006 - 13,996,684RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01013,778,990 - 13,813,725RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41013,848,210 - 13,883,189RGD_MAPPER_PIPELINERGSC3.4






References

References - curated
# Reference Title Reference Citation
1. Spontaneous and radiation-induced renal tumors in the Eker rat model of dominantly inherited cancer. Hino O, etal., Proc Natl Acad Sci U S A 1993 Jan 1;90(1):327-31.
2. Transgenic rescue from embryonic lethality and renal carcinogenesis in the Eker rat model by introduction of a wild-type Tsc2 gene. Kobayashi T, etal., Proc Natl Acad Sci U S A 1997 Apr 15;94(8):3990-3.
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics Excellent example of a mendelian dominant predisposition to a specific cancer in an experimental animal. The Eker mutation is tightly linked to the Tsc2 gene. Renal carcinoma is developed in multiple stages from early preneoplastic lesions. This model is highly susceptible to particular cancers, develops multiple renal tumors. The Eker rat has a single gene mutation in the Tsc2 gene that develops into four different tumors in the kidney, spleen, uterus and pitutary. 625660
strain_drgs_chems TGHQ ((2,3,5-tris-glutathion-S-yl)hydroquinone) treated rats have increased cell proliferation which leads to the development of renal tumors. 628401
strain_life_disease Eker rats develop multicentric, bilateral tumors that are scattered throughout the renal cortex and the medulla. Male rats have approximately double the number of tumors as the female at 10 months of age. 625660
strain_phys_biochem After unilateral nephrectomy these were diagnosed as carriers for the histologic detection of tumors in the kidney of at 4-10 months of age. Most tumors have periodic acid/ Schiff-negative large cells with clear, finely granular or vacuolated cytoplasm. Some tumors are cystic or have papillary projections. Derived cell lines represent tumor cell derivatives. 628401

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-07 LETsc2Eker/Hin    Eker-Tsc2/Hin    Symbol updated 68687 APPROVED
2017-03-07 LETsc2Eker/Hin    Eker-Tsc2/Hin    Symbol updated 68687 APPROVED