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Strain Registration

Strain: WKY/NCrlCrlj

Symbol: WKY/NCrlCrlj
Strain: WKY
Substrain: NCrlCrlj
RGD ID: 61119
Citation ID: RRID:RGD_61119
Ontology ID: RS:0001036
Previously known as: WKY/NCrlj; NBRP Rat No: 0510
Type: inbred
Source: Charles River Laboratories Japan, National BioResource Project for the Rat in Japan
Origin: Originated from outbred Wistar of Kyoto University. To NIH from Kyoto University in 1971 and sib mating has started. To Charles River Laboratories, Inc from NIH in 1974 at F11, and to Charles River Japan, Inc. in 1981 at F25. (May 27, 2010). Used as control strain for the SHR strain.
Coat Color: Albino
Last Known Status: Live Animals; Cryopreserved Embryo (as of 2023-05-30)





Experimental Data Annotations    Click to see Annotation Detail View

Rat Strain
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
WKY/NCrlCrlj  IEA 7241799 RGD 

Vertebrate Trait
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
arterial blood pressure trait  EXP 2303163 RGD 
thymus mass  EXP 70859; 634747 RGD 
urine total protein amount  EXP 619599; 2292230 RGD 

Phenotype Values via Phenominer Click to see Annotation Detail View

Related Phenotype Data for Term "WKY/NCrlCrlj" (RS:0001036)

Rat Strains:
Clinical Measurements:
Experimental Conditions:
Measurement Methods:

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table

Clinical Measurement
heart rate
systolic blood pressure
body weight
body temperature
red blood cell count
blood hemoglobin level
white blood cell count
platelet count
hematocrit
mean corpuscular volume
plasma glucose level
plasma aspartate aminotransferase activity level
plasma alanine aminotransferase activity level
plasma alkaline phosphatase activity level
plasma total protein level
plasma albumin level
plasma phosphate level
plasma chloride level
plasma sodium level
plasma potassium level
heart wet weight
heart weight to body weight ratio
both kidneys wet weight
lung wet weight
urine potassium level
urine sodium level
brain weight to body weight ratio
both kidneys wet weight as percentage of body weight
liver weight as percentage of body weight
spleen weight to body weight ratio
brain wet weight
lung weight to body weight ratio
liver wet weight
both adrenal glands wet weight
spleen wet weight
both testes wet weight
activated partial thromboplastin time
prothrombin time
timed urine volume
mean corpuscular hemoglobin
mean corpuscular hemoglobin concentration
blood basophil count to total leukocyte count ratio
blood eosinophil count to total leukocyte count ratio
blood lymphocyte count to total leukocyte count ratio
blood monocyte count to total leukocyte count ratio
total plasma calcium level
urine chloride level
plasma creatinine level
plasma triglyceride level
plasma total cholesterol level
plasma urea nitrogen level
thymus weight to body weight ratio
both adrenal glands weight to body weight ratio
both testes wet weight to body weight ratio
liver cholesterol level
urine sodium excretion rate to body weight ratio
brain cholesterol level
brain phytosterol level
brain campesterol level
brain sitosterol level
liver sitosterol level
liver campesterol level
liver phytosterol level
plasma sitosterol level
plasma campesterol level
plasma phytosterol level
timed urine volume to body weight ratio
urine chloride excretion rate to body weight ratio
urine potassium excretion rate to body weight ratio
plasma total bilirubin level
blood segmented neutrophil count to total leukocyte count ratio
blood band neutrophil count to total leukocyte count ratio
non-specified leukocyte count to total leukocyte count ratio
plasma albumin to plasma total protein ratio

References

References - curated
# Reference Title Reference Citation
1. Actin -related protein 3 (Arp3) is mutated in proteinuric BUF/Mna rats. Akiyama K, et al., Mamm Genome. 2008 Jan;19(1):41-50. Epub 2007 Dec 7.
2. Mapping of two genetic loci, Ten-1 and Ten-2, associated with thymus enlargement in BUF/Mna rats. Murakumo Y, etal., Mamm Genome 1996 Jul;7(7):505-8.
3. A genetic locus susceptible to the overt proteinuria in BUF/Mna rat. Murayama S, etal., Mamm Genome 1998 Nov;9(11):886-8.
4. Strains registered by Charles River Laboratories International, Inc. Personal communication with Charles River Laboratories
5. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
6. RGD Strain RSO annotation pipeline RGD Automated Pipelines
7. Analysis and comparison of new candidate loci for hypertension between genetic hypertensive rat strains. Takami S, etal., Hypertens Res. 1996 Mar;19(1):51-6.
8. Congenic strains confirm the presence of salt-sensitivity QTLs on chromosome 1 in the Sabra rat model of hypertension. Yagil C, etal., Physiol Genomics 2003 Jan 15;12(2):85-95.
9. Fine mapping of thymus enlargement gene 1 (Ten1) in BUF/Mna rats. Ye C, etal., Pathol Int 2000 Mar;50(3):185-90.

Region

Strain QTL Data
Symbol Name Trait
Bp330 Blood pressure QTL 330 arterial blood pressure trait   (VT:2000000)    
Bp331 Blood pressure QTL 331 arterial blood pressure trait   (VT:2000000)    
Bp332 Blood pressure QTL 332 arterial blood pressure trait   (VT:2000000)    
Pur1 Proteinuria QTL 1 urine total protein amount   (VT:0000032)    
Pur16 Proteinuria QTL 16 urine total protein amount   (VT:0000032)    
Thym1 Thymus enlargement QTL 1 thymus mass   (VT:0004954)    
Thym2 Thymus enlargement QTL 2 thymus mass   (VT:0004954)    
Thym4 Thymus enlargement QTL 4 thymus mass   (VT:0004954)    

Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-05-29 WKY/NCrlCrlj    WKY/NCrlCrlj    Name updated 68913 APPROVED
2012-05-29 WKY/NCrlCrlj    WKY/NCrlCrlj    Name updated 68913 APPROVED