Strain Report - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Strain Registration

Strain: DA/Slc

Symbol: DA/Slc
Strain: DA
Substrain: Slc
Full Name: dark agouti
RGD ID: 61111
Citation ID: RRID:RGD_61111
Ontology ID: RS:0000247
Also Known As: NBRP Rat No: 0157; MDC-02-72
Type: inbred
Available Source: National BioResource Project for the Rat in Japan
Origination: National BioResource Project for the Rat in Japan
Description: These were produced by from SD parents in 1984 by hysterectomy and fostering, then moved to Kumamoto University of Medicine in 1983.
Coat Color: Agouti
Inbred Generations: F48
Last Known Status: Live Animals





Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table

Clinical Measurement
heart rate
systolic blood pressure
body weight
body temperature
red blood cell count
blood hemoglobin level
white blood cell count
platelet count
hematocrit
mean corpuscular volume
plasma glucose level
plasma aspartate aminotransferase activity level
plasma alanine aminotransferase activity level
plasma alkaline phosphatase activity level
plasma total protein level
plasma albumin level
plasma phosphate level
plasma chloride level
plasma sodium level
plasma potassium level
heart wet weight
heart weight to body weight ratio
both kidneys wet weight
lung wet weight
urine potassium level
urine sodium level
brain weight to body weight ratio
both kidneys wet weight as percentage of body weight
liver weight as percentage of body weight
spleen weight to body weight ratio
brain wet weight
lung weight to body weight ratio
liver wet weight
both adrenal glands wet weight
kidney wet weight
spleen wet weight
both testes wet weight
activated partial thromboplastin time
prothrombin time
timed urine volume
mean corpuscular hemoglobin
mean corpuscular hemoglobin concentration
blood basophil count to total leukocyte count ratio
blood eosinophil count to total leukocyte count ratio
blood lymphocyte count to total leukocyte count ratio
blood monocyte count to total leukocyte count ratio
total plasma calcium level
urine chloride level
plasma creatinine level
plasma triglyceride level
plasma total cholesterol level
plasma urea nitrogen level
both adrenal glands weight to body weight ratio
single kidney wet weight to body weight ratio
plasma high density lipoprotein cholesterol level
plasma low density lipoprotein cholesterol level
urine total protein excretion rate
both testes wet weight to body weight ratio
urine sodium excretion rate to body weight ratio
squamous cell carcinoma of the tongue maximum tumor diameter
squamous cell carcinoma of the head and neck tumor number
non-tongue squamous cell carcinoma of the head and neck tumor number
squamous cell carcinoma of the tongue tumor number
number of squamous cell tumors of the tongue with diameter greater than 5 mm
post-insult time to onset of moribundity
number of squamous cell tumors of the tongue with diameter greater than 3 mm
timed urine volume to body weight ratio
urine chloride excretion rate to body weight ratio
urine potassium excretion rate to body weight ratio
plasma total bilirubin level
blood segmented neutrophil count to total leukocyte count ratio
blood band neutrophil count to total leukocyte count ratio
non-specified leukocyte count to total leukocyte count ratio
plasma albumin to plasma total protein ratio

References

References - curated
# Reference Title Reference Citation
1. Genetic mapping found major QTLs for antibody-induced glomerulonephritis in WKY rats. Kose H, etal., Exp Anim. 2009 Apr;58(2):193-8.
2. A set of highly informative rat simple sequence length polymorphism (SSLP) markers and genetically defined rat strains. Mashimo T, etal., BMC Genet. 2006 Apr 4;7:19.
3. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
4. RGD Strain RSO annotation pipeline RGD Automated Pipelines
5. SNP and haplotype mapping for genetic analysis in the rat. Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
6. Chromosomal mapping of host resistance loci to Trichinella spiralis nematode infection in rats. Suzuki T, etal., Immunogenetics. 2006 Feb 8;:1-5.
7. Quantitative trait loci affecting 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in the rat. Tanuma J, etal., Cancer Res 1998 Apr 15;58(8):1660-4

Region

Cell Lines
Symbol
DA/Slc-ES1/Nips
DA/Slc-ES2/Nips

Strain QTL Data
Symbol Name Trait
Kidm41 Kidney mass QTL 41 kidney mass   (VT:0002707)    
Pur17 Proteinuria QTL 17 urine protein amount   (VT:0005160)    
Tcas1 Tongue tumor susceptibility QTL 1 tongue integrity trait   (VT:0010553)    
Tcat1 Tongue tumor resistance QTL 1 tongue integrity trait   (VT:0010553)    
Tspe1 Trichinella spiralis expulsion QTL 1 parasite quantity   (VT:0010441)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_infection displays strong host response to intestinal nematode parasite Trichinella spiralis infection with expulsion of intestinal worms 1578305
strain_life_disease These are susceptible to allergic encephalomyelitis, collagen induced arthritis and other auto-immune diseases. 61091

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-05-10 DA/Slc  dark agouti  DA/Slc  dark agouti  Name updated 68913 APPROVED