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Strain: LN/MavRrrc

Symbol: LN/MavRrrc
Strain: LN
Substrain: MavRrrc
Full Name: lyon normotensive
RGD ID: 61015
Citation ID: RRID:RRRC_00058
Ontology ID: RS:0000559
Type: inbred
Available Source: Rat Resource and Research Center
Origination: Rat Resource and Research Center
Description: (taken from Lyon Hypertensive entry, see LH) In 1969 outbred Sprague-Dawley rats were selected for high systolic blood pressure using an indirect plethysmographic technique in pre-warmed unrestrained conscious rats. Three pairs were originally selected, and selection was continued with brother x sister mating. Strain LN was maintained as a normotensive control, and LL as a hypotensive strain. (see Vincent et al 1984, and Vincent and Sassard, 1994 for reviews).
Genetic Markers: c
Coat Color: Albino
Inbred Generations: F27
Last Known Status: Cryopreserved Embryo; Cryopreserved Sperm





Experimental Data Annotations    Click to see Annotation Detail View

Rat Strain
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
LN/MavRrrc  IEA 7241799 RGD 

Vertebrate Trait
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
arterial blood pressure trait  EXP 61058; 68932 RGD 

Phenotype Values via Phenominer Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Inbred Strains Festing, MFW, Inbred Strains, The Laboratory Rat, 1979, Baker HK, Lindsey JR, Weisbroth SH, 55-72, Academic Press
2. Update to previous Strain Data Festing, MFW, Personal Communication Update, Feb-2000
3. Data registered by the Rat Resource & Research Center Personal Communication with Rat Resource & Research Center
4. RGD Strain RSO annotation pipeline RGD Automated Pipelines
5. New target regions for human hypertension via comparative genomics. Stoll M, etal., Genome Res 2000 Apr;10(4):473-82.
6. A pharmacogenetic approach to blood pressure in Lyon hypertensive rats. A chromosome 2 locus influences the response to a calcium antagonist. Vincent M, etal., J Clin Invest 1997 Oct 15;100(8):2000-6

Region

Strain QTL Data
Symbol Name Trait
Bp357 Blood pressure QTL 357 arterial blood pressure trait   (VT:2000000)    
Bp50 Blood pressure QTL 50 arterial blood pressure trait   (VT:2000000)    
BpQTLCluster2 Blood pressure QTL cluster 2 arterial blood pressure trait   (VT:2000000)    
Strain Samples in RGD with Damaging Variants (Polyphen)
AssemblySample 
RGSC_v3.4 LN/MavRrrc (ICL) View Damaging Variants
Rnor_5.0 LN/MavRrrc (KNAW) View Damaging Variants
Rnor_6.0 LN/MavRrrc (RGD) View Damaging Variants


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-01-11 LN/MavRrrc  lyon normotensive  LN  lyon normotensive  Symbol and/or name change 68913 APPROVED

Database Acc Id Source(s)
RRRC RRRC:00058 RGD