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Strain: BB/N

Symbol: BB/N
Strain: BB
Substrain: N
Full Name: BioBreeding rat
RGD ID: 61011
Citation ID: RRID:RRRC_00144
Ontology ID: RS:0001172
Type: inbred
Available Source: Not Available
Description: Mutation causing diabetes mellitus in a closed colony of outbred Wistar rats at Bio-Breeding Labs, Ontario, Canada in 1974 (Chappel and Chappel 1983). To Worcester in 1977 where inbreeding began. Sublines of diabetic-prone and diabetic-resistant animals have been developed, and there are also subline differences in the incidence, age of onset, untreated survival time of diabetes, leucopenia and body weight gain which can be attributed to genetic factors (Kloting et al 1987). A detailed study of 24 inbred and two outbred lines of diabetes-prone and diabetes resistant BB rats using eight marker loci found substantial genetic variation among and some variation within some of the colonies. The 22 colonies which were apparently isogenic could be divided into four groups on the basis of the marker loci (Prins et al 1990).
Genetic Markers: c
Coat Color: Albino
Inbred Generations: F30
Last Known Status: Extinct


References - curated
# Reference Title Reference Citation
1. Spontaneous diabetes mellitus syndrome in the rat. I. Association with the major histocompatibility complex. Colle E, etal., J Exp Med 1981 Oct 1;154(4):1237-42
2. Inbred Strains Festing, MFW, Inbred Strains, The Laboratory Rat, 1979, Baker HK, Lindsey JR, Weisbroth SH, 55-72, Academic Press
3. Update to previous Strain Data Festing, MFW, Personal Communication Update, Feb-2000
4. Diabetes and hypertension in rodent models. Kloting I, etal., Ann N Y Acad Sci 1997 Sep 20;827:64-84.
5. Mapping of novel genes predisposing or protecting diabetes development in the BB/OK rat. Kloting I, etal., Biochem Biophys Res Commun 1998 Apr 17;245(2):483-6
6. Data registered by the Rat Resource & Research Center Personal Communication with Rat Resource & Research Center
7. RGD Strain RSO annotation pipeline RGD Automated Pipelines


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics The development of lymphocytic thyroiditis is not affected by iodine treatment according to Allen (1992), though Ebner et al (1992) found that it does have some affect. Epitope specificities of collagen-induced arthritis studied by Cremer et al (1992). A lymphopenic, nondiabetic substrain BB-DR has very low T-cell numbers, depressed B-lymphocyte numbers and a complete absence of peripheral CD8+ T cells characteristics of the susceptible BB strain(Joseph et al 1993). Transfusing of BB-DR thymocytes into nude rats transfers the autoimmune insulin-dependent diabetes mellitus (Whalen et al 1995). The percentage of animals getting diabetes by 200 days of age depends on the sex distribution within litters and the phenotype of the parents. A maximum likelihood model for predicting the incidence of diabetes each generation has been developed by Vogt and Kloting (1993). In-vitro study of perfused islets suggested that diabetes is due to a reduction on beta cell mass (Teruya et al 1993). Endothelin urinary excretion is increased in diabetic BB rats (Morabito et al 1994). 634612
strain_drgs_chems The sulfonylurea drug glipizide delays onset and decreases the incidence of diabetes (Hosszufalusiet al 1994) 634612
strain_life_disease Abrupt onset of insulin-dependent, ketosis-prone diabetes between 60 and 120 days of age. Animals exhibit lymphocyte insulinitis with virtually complete destruction of pancreatic beta cells; Tcell lymphopenia; lymphocytic thyroiditis, and autoantibodies to smooth muscle, thyroid colloid,and gastric parietal cells. T cell lymphopenia is due largely to the absence of RT6+ peripheral Tcell subset, including members of both helper/inducer and suppressor/cytotoxic antigenic phenotypes (Greiner et al 1986). These animals develop an acute form of spontaneous diabetes mellitus. Hyperglycemia, low-serum insulin levels, ketonuria, and weight loss are the main characteristics. 634612
strain_other Reported to be extinct from the Rat Resource & Research Center as of 26/08/2011. 2292495
strain_phys_biochem Isolated, perfused kidneys from diabetic animals show higher basal renin release and kidney renin content than kidneys from nondiabetic controls. Renin-secretory response to beta-adrenergic stimulation impaired (Cohen et al 1986). About 32% of diabetic rats develop gastric erosions and ulcerations compared with only 10% ofnon-diabetic BB rats (Wright et al 1981). Further discussions of the characteristics of this model are given in Metabolism 32 no 7 suppl.1, (1983) and in Mordes et al (1987). Poly I:C accelerates the development of diabetes both in diabetes-prone and resistant substrains (Sobel et al 1992,Ewel et al 1992). 634612
strain_reproduction Average litter size at weaning 6.5 pups for diabetic-prone and 7.2 pups for the diabetic-resistant colonies. 61077
Database Acc Id Source(s)