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Strain: PVG

Symbol: PVG
Strain: PVG
Full Name: PVG
RGD ID: 61006
Citation ID: RRID:RGD_61006
Ontology ID: RS:0000224
Type: inbred
Source: Not Available
Origin: Kings College of Household Science, to Lister Institute, to Virol, to Glaxo 1946. Inbred by Glaxo. A substrain PVG/cBkl, which is C6 complement deficient due, presumably, to a spontaneous mutation has been described. In good environmental conditions it is perfectly healthy (Leenaerts et al, 1994).
Genetic Markers: a,C,h
Coat Color: Black hooded.
Inbred Generations: F70+?
Last Known Status: Unknown





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Mammalian Phenotype

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
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References

References - curated
# Reference Title Reference Citation
1. Two genes in the rat homologous to human NKG2. Berg SF, etal., Eur J Immunol 1998 Feb;28(2):444-50
2. An autosomal dominant locus, Nka, mapping to the Ly-49 region of a rat natural killer (NK) gene complex, controls NK cell lysis of allogeneic lymphocytes. Dissen E, etal., J Exp Med 1996 May 1;183(5):2197-207
3. Inbred Strains Festing, MFW, Inbred Strains, The Laboratory Rat, 1979, Baker HK, Lindsey JR, Weisbroth SH, 55-72, Academic Press
4. Update to previous Strain Data Festing, MFW, Personal Communication Update, Feb-2000
5. Induction of type I diabetes by Kilham's rat virus in diabetes-resistant BB/Wor rats. Guberski DL, etal., Science. 1991 Nov 15;254(5034):1010-3.
6. Ocular infection with herpes simplex virus in several strains of rat. Nicholls SM, etal., Invest Ophthalmol Vis Sci. 1994 Jul;35(8):3260-7.
7. RGD Strain RSO annotation pipeline RGD Automated Pipelines
8. Attenuation of experimental allergic encephalomyelitis in complement component 6-deficient rats is associated with reduced complement C9 deposition, P-selectin expression, and cellular infiltrate in spinal cords. Tran GT, etal., J Immunol 2002 May 1;168(9):4293-300.
9. Identification of rat quantitative trait loci that regulate LPS-induced pro-inflammatory cytokine responses. Xu H, etal., Scand J Immunol 2002 Sep;56(3):248-53.

Region

Strain QTL Data
Symbol Name Trait
Nka1 Natural killer alloreactivity QTL 1 natural killer cell cytolysis trait   (VT:0005070)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_life_disease Suceptible to infection by Entamoeba histolytica (Neal and Harris 1975). Lower incidence of polyspermia than in WAG (Braden 1958). A subline with a chromosome marker analogous to the CBA-T6 mouse strain has been developed by Howard (1971), and PVG is used as the genetic background strain for a number of RT1 and other congenic strains (eg Chisholm et al 1977, Hunt and Fowler 1981). Resistant to the development of glomerular sclerosis following unilateral nephrectomy, in contrast to Wistar and most other rat strains (Grond et al 1986). Moderately sensitive to the development of experimental glomerulonephritis following injection of nephritogenic antigen from bovine renal basement membrane (Naito et al, 1991). Resistant (4/4) to ocular infection with herpes simplex virus with 60% survival after infection with 104 plaque forming units. LEW was relatively susceptible; all died after infection with 4x102 pfu (Nicholls et al, 1994). Develops less inflammation than AO following injection of and E1-deleted non-replicating human adenovirus type 5 vector (Byrnes et al, 1995). Susceptible to tissue injury following dosing with 1.0 or 1.33 g/kg of sodium chloride with 80% submucosal oedema compared with only 10% in Sprague-Dawley (Fraser et al, 1992). 1004
strain_life_disease Suceptible to infection by Entamoeba histolytica (Neal and Harris 1975). Lower incidence of polyspermia than in WAG (Braden 1958). A subline with a chromosome marker analogous to the CBA-T6 mouse strain has been developed by Howard (1971), and PVG is used as the genetic background strain for a number of RT1 and other congenic strains (eg Chisholm et al 1977, Hunt and Fowler 1981). Resistant to the development of glomerular sclerosis following unilateral nephrectomy, in contrast to Wistar and most other rat strains (Grond et al 1986). Moderately sensitive to the development of experimental glomerulonephritis following injection of nephritogenic antigen from bovine renal basement membrane (Naito et al, 1991). Resistant (4/4) to ocular infection with herpes simplex virus with 60% survival after infection with 104 plaque forming units. LEW was relatively susceptible; all died after infection with 4x102 pfu (Nicholls et al, 1994). Develops less inflammation than AO following injection of and E1-deleted non-replicating human adenovirus type 5 vector (Byrnes et al, 1995). Susceptible to tissue injury following dosing with 1.0 or 1.33 g/kg of sodium chloride with 80% submucosal oedema compared with only 10% in Sprague-Dawley (Fraser et al, 1992). 61084
strain_life_disease Suceptible to infection by Entamoeba histolytica (Neal and Harris 1975). Lower incidence of polyspermia than in WAG (Braden 1958). A subline with a chromosome marker analogous to the CBA-T6 mouse strain has been developed by Howard (1971), and PVG is used as the genetic background strain for a number of RT1 and other congenic strains (eg Chisholm et al 1977, Hunt and Fowler 1981). Resistant to the development of glomerular sclerosis following unilateral nephrectomy, in contrast to Wistar and most other rat strains (Grond et al 1986). Moderately sensitive to the development of experimental glomerulonephritis following injection of nephritogenic antigen from bovine renal basement membrane (Naito et al, 1991). Resistant (4/4) to ocular infection with herpes simplex virus with 60% survival after infection with 104 plaque forming units. LEW was relatively susceptible; all died after infection with 4x102 pfu (Nicholls et al, 1994). Develops less inflammation than AO following injection of and E1-deleted non-replicating human adenovirus type 5 vector (Byrnes et al, 1995). Susceptible to tissue injury following dosing with 1.0 or 1.33 g/kg of sodium chloride with 80% submucosal oedema compared with only 10% in Sprague-Dawley (Fraser et al, 1992). 634612
strain_phys_biochem Rats that are unable to form membrane attack complex, that are deficient in C6 component of the compliment (PVG/C6-) develop milder experimental allergic encephalomyelitis (EAE) than PVG/C rats. 1004
strain_phys_biochem Rats that are unable to form membrane attack complex, that are deficient in C6 component of the compliment (PVG/C6-) develop milder experimental allergic encephalomyelitis (EAE) than PVG/C rats. 61084
strain_phys_biochem Rats that are unable to form membrane attack complex, that are deficient in C6 component of the compliment (PVG/C6-) develop milder experimental allergic encephalomyelitis (EAE) than PVG/C rats. 634612
strain_reproduction Docile and good breeding performance. Short gestation period (2/8) (Peters 1986). 1004
strain_reproduction Docile and good breeding performance. Short gestation period (2/8) (Peters 1986). 634612