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Strain Registration

Strain: OM/N

Symbol: OM/N
Strain: OM
Substrain: N
Full Name: Osborne-Mendel
RGD ID: 61005
Citation ID: RRID:RGD_61005
Ontology ID: RS:0000631
Type: inbred
Source: NIH Autoimmune Rat Model Repository and Development Center
Origin: Heston 1946 from non-inbred Osborne-Mendel stock obtained from J White, to NIH at F10 (Hansen et al 1982).
Genetic Markers: c
Coat Color: Albino.
Inbred Generations: F100
Last Known Status: Extinct






References

References - curated
# Reference Title Reference Citation
1. Inbred Strains Festing, MFW, Inbred Strains, The Laboratory Rat, 1979, Baker HK, Lindsey JR, Weisbroth SH, 55-72, Academic Press
2. Update to previous Strain Data Festing, MFW, Personal Communication Update, Feb-2000
3. NIH Rat Strain Data NIH Rat Strain Data
4. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics Used in studies of effects of fluoride on tooth enamel and dental plaque by Shern and Couet (1979) and Shern et al (1979). 1004
strain_characteristics Used in studies of effects of fluoride on tooth enamel and dental plaque by Shern and Couet (1979) and Shern et al (1979). 634612
strain_life_disease Spontaneous thyroid carcinoma 33% (Lindsey et al 1968). Adrenal cortical tumours 94% and pituitary tumours 8-18% at 18 months (Hansen et al 1973). In animals over 18 months Snell found adenomas or carcinomas of adrenal cortex 73% in males and 95% in females, pituitary tumours 25%, granulosa cell tumours of the ovary 33% in females. Animals were also relatively resistant to development of nephritis (Snell 1965). Poor survival to 2-years of age at 43% (rank 5/5) in males and 38% (rank 5/5) in females with relatively severe chronic renal disease and an intermediate level of hydronephrosis which may make the strain unsuitable for long-term toxicity studies (Solleveld and Boorman 1986). Very susceptible to chronic respiratory disease (Greenhouse et al 1991). 1004
strain_life_disease Spontaneous thyroid carcinoma 33% (Lindsey et al 1968). Adrenal cortical tumours 94% and pituitary tumours 8-18% at 18 months (Hansen et al 1973). In animals over 18 months Snell found adenomas or carcinomas of adrenal cortex 73% in males and 95% in females, pituitary tumours 25%, granulosa cell tumours of the ovary 33% in females. Animals were also relatively resistant to development of nephritis (Snell 1965). Poor survival to 2-years of age at 43% (rank 5/5) in males and 38% (rank 5/5) in females with relatively severe chronic renal disease and an intermediate level of hydronephrosis which may make the strain unsuitable for long-term toxicity studies (Solleveld and Boorman 1986). Very susceptible to chronic respiratory disease (Greenhouse et al 1991). 634612
strain_phys_biochem High blood pressure (3/23), reaching 154_1.0 (SEM) mmHg at 10 weeks of age (Tanase et al 1982). Mammary tumours 26-30%. High incidence of retinal degeneration in animals over 10 months (von Sallman and Grimes 1972, 1974). High systolic blood pressure (2/17) (Hansen et al 1973). Becomes obese on a high fat diet (1/7) (Schemmel et al 1970, Buchanan et al, 1992). Enterostatin inhibited the uptake of high, but not low fat diets after an overnight fast (contrast strain S5B) (Okada et al, 1992). High 10-week body weight in males (20/23) (Tanase et al 1982). 1004
strain_phys_biochem High blood pressure (3/23), reaching 154_1.0 (SEM) mmHg at 10 weeks of age (Tanase et al 1982). Mammary tumours 26-30%. High incidence of retinal degeneration in animals over 10 months (von Sallman and Grimes 1972, 1974). High systolic blood pressure (2/17) (Hansen et al 1973). Becomes obese on a high fat diet (1/7) (Schemmel et al 1970, Buchanan et al, 1992). Enterostatin inhibited the uptake of high, but not low fat diets after an overnight fast (contrast strain S5B) (Okada et al, 1992). High 10-week body weight in males (20/23) (Tanase et al 1982). 634612
strain_reproduction Intermediate breeding performance (8/12) and good litter size (4/12) (Hansen et al 1973). 1004
strain_reproduction Intermediate breeding performance (8/12) and good litter size (4/12) (Hansen et al 1973). 634612