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Strain: BDIX

Symbol: BDIX
Strain: BDIX
RGD ID: 61002
Citation ID: RRID:RGD_61002
Ontology ID: RS:0000091
Type: inbred
Available Source: Not Available
Description: Druckrey from a cross between BDI and BDVIII with subsequent selection of brother-sister pairs for agouti coat color and dark, pigmented eyes. NB. Druckrey 1937 from a yellow, pink-eyed strain. Inbred and reduced to one pair after World War II. Crosses with Wistar stock and subsequent inbreeding led to the development of BDII. According to Druckrey (1971), strains BDIII-BDX were then developed from a cross of a single BDI x BDII mating pair, with subsequent selection for coat colour alleles. However, the strains have four different RT1 haplotypes (d, v, l and e) rather than the two that would be expected from such a cross (Stark and Zeiss 1970). The strains can _not_ be regarded as a set of recombinant inbred strains as defined by Bailey (1971), although their definition by coat colour alleles makes the set easily identifiable , and should help (but not guarantee!) to ensure authenticity. According to Druckrey (1971), all strains have a low tumour incidence, with a median life-span of 700-950 days, depending on strain.
Genetic Markers: A,C,H,P
Coat Color: Agouti
Inbred Generations: F46(N)
Last Known Status: Unknown





References

References - curated
# Reference Title Reference Citation
1. Inbred Strains Festing, MFW, Inbred Strains, The Laboratory Rat, 1979, Baker HK, Lindsey JR, Weisbroth SH, 55-72, Academic Press
2. Update to previous Strain Data Festing, MFW, Personal Communication Update, Feb-2000
3. Rat Strain List M. Festing Rat Strain List
4. RGD Strain RSO annotation pipeline RGD Automated Pipelines
5. Herpes simplex virus thymidine kinase gene therapy in experimental rat BT4C glioma model: effect of the percentage of thymidine kinase-positive glioma cells on treatment effect, survival time, and tissue reactions. Sandmair AM, etal., Cancer Gene Ther. 2000 Mar;7(3):413-21. doi: 10.1038/sj.cgt.7700132.

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_anatomy Shows delayed development of the secondary centre of ossification of the epiphyses of the long bones compared with seven other strains (Stark et al, 1995). 1004
strain_anatomy Shows delayed development of the secondary centre of ossification of the epiphyses of the long bones compared with seven other strains (Stark et al, 1995). 634612
strain_immunology Haematiology described by Lovell et al (1981); high MCHC (7/7), neutrophils (7/7), low lymphocytes (1/7), high monocytes (7/7), high eosinophils (7/7). 1004
strain_immunology Haematiology described by Lovell et al (1981); high MCHC (7/7), neutrophils (7/7), low lymphocytes (1/7), high monocytes (7/7), high eosinophils (7/7). 634612
strain_life_disease Strain widely used in carcinogenesis and teratogenesis studies. Highly susceptible to the transplacental induction of malignant tumours of the central nervous system by ethyl nitrosourea (Druckrey et al 1970). A transplantable monocytic-myeloid leukaemia L5222 induced by ethyl nitrosourea has been used as a model for chemotherapy (Ivankovic and Zeller 1974). Transplantable colon tumour PROb grows progressively and metastasizes, whereas REGb grows slowly and is then rejected (Blottiere et al 1992a,b). DHD/K12 colon adenocarcinoma cells also metastasize, but RC-160 acts as an inhibitor (Qin et al 1992). These models have been used to study methods of treating peritoneal carcinoma including shockwave cavitation (Prat et al 1993) and the somatostatiin analog Lanreotide and the GRP antagonist BIM-26226 (Gouyon et al 1995). A transplantable ovarian carcinoma O-342 has been used in studies of potential chemotherapeutic use of a methotrexate-albumin conjugate (Steinmann et al 1995).Transplantable Sp-5 colorectal adenocarcinoma has been used in the study of the chemotherapeutic effects of 2-deoxy-5-fluorouridine for pulmonary metastises (Ng et al 1995). Has a defect in the expression of RT1.B, apparently due to absence of structural or controling gene (Male et al 1987). The activity of C-jun, JunB, JunD, Krox-24 and C-fos in the brain shows individual patterns of expression in untreated animals (Herdegen et al 1995). 1004
strain_life_disease Strain widely used in carcinogenesis and teratogenesis studies. Highly susceptible to the transplacental induction of malignant tumours of the central nervous system by ethyl nitrosourea (Druckrey et al 1970). A transplantable monocytic-myeloid leukaemia L5222 induced by ethyl nitrosourea has been used as a model for chemotherapy (Ivankovic and Zeller 1974). Transplantable colon tumour PROb grows progressively and metastasizes, whereas REGb grows slowly and is then rejected (Blottiere et al 1992a,b). DHD/K12 colon adenocarcinoma cells also metastasize, but RC-160 acts as an inhibitor (Qin et al 1992). These models have been used to study methods of treating peritoneal carcinoma including shockwave cavitation (Prat et al 1993) and the somatostatiin analog Lanreotide and the GRP antagonist BIM-26226 (Gouyon et al 1995). A transplantable ovarian carcinoma O-342 has been used in studies of potential chemotherapeutic use of a methotrexate-albumin conjugate (Steinmann et al 1995).Transplantable Sp-5 colorectal adenocarcinoma has been used in the study of the chemotherapeutic effects of 2-deoxy-5-fluorouridine for pulmonary metastises (Ng et al 1995). Has a defect in the expression of RT1.B, apparently due to absence of structural or controling gene (Male et al 1987). The activity of C-jun, JunB, JunD, Krox-24 and C-fos in the brain shows individual patterns of expression in untreated animals (Herdegen et al 1995). 634612