Strain Report - Rat Genome Database

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Strain: COP

Symbol: COP
Strain: COP
RGD ID: 60998
Citation ID: RRID:RGD_60998
Ontology ID: RS:0000184
Previously known as: Copenhagen rat
Type: inbred
Source: Not Available
Origin: This Copenhagen (COP) rat was an inbred strain from Curtiss 1921 at Columbia University Institute for Cancer Research.
Genetic Markers: a,h.
Coat Color: Black hooded.
Inbred Generations: F49 (Pcr1988).
Last Known Status: Unknown

Substrains
COP/CrCrl
COP/OlaHsd





References

References - curated
# Reference Title Reference Citation
1. Inbred Strains Festing, MFW, Inbred Strains, The Laboratory Rat, 1979, Baker HK, Lindsey JR, Weisbroth SH, 55-72, Academic Press
2. Update to previous Strain Data Festing, MFW, Personal Communication Update, Feb-2000
3. Genetic identification of Mcs-1, a rat mammary carcinoma suppressor gene. Hsu LC, etal., Cancer Res 1994 May 15;54(10):2765-70
4. Rat Strain List M. Festing Rat Strain List
5. RGD Strain RSO annotation pipeline RGD Automated Pipelines
6. Genetic identification of multiple loci that control breast cancer susceptibility in the rat Shepel LA, etal., Genetics 1998 May;149(1):289-99

Region

Strain QTL Data
Symbol Name Trait
Hcar13 Hepatocarcinoma resistance QTL 13 liver integrity trait   (VT:0010547)    
Hcar14 Hepatocarcinoma resistance QTL 14 liver integrity trait   (VT:0010547)    
Hcas5 Hepatocarcinoma susceptibility QTL 5 liver integrity trait   (VT:0010547)    
Hcas6 Hepatocarcinoma susceptibility QTL 6 liver integrity trait   (VT:0010547)    
Hcas7 Hepatocarcinoma susceptibility QTL 7 liver integrity trait   (VT:0010547)    
Lnnr3 Liver neoplastic nodule remodeling QTL 3 liver integrity trait   (VT:0010547)    
Lnnr4 Liver neoplastic nodule remodeling QTL 4 liver integrity trait   (VT:0010547)    
Lnnr5 Liver neoplastic nodule remodeling QTL 5 liver integrity trait   (VT:0010547)    
Lnnr6 Liver neoplastic nodule remodeling QTL 6 liver integrity trait   (VT:0010547)    
Mcs1 Mammary carcinoma susceptibility QTL 1 mammary gland integrity trait   (VT:0010552)    
Mcs2 Mammary carcinoma susceptibility QTL 2 mammary gland integrity trait   (VT:0010552)    
Mcs3 Mammary carcinoma susceptibility QTL 3 mammary gland integrity trait   (VT:0010552)    
Mcs4 Mammary carcinoma susceptibility QTL 4 mammary gland integrity trait   (VT:0010552)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_drgs_chems Slow absorption of diethylstilboestrol leading to death from bladder calculi and papillomas (Dunning and Curtis 1946, Dunning et al 1947). Resistant to mammary tumour induction by7,12-dimethylbenz[a]anthracene at doses which in strains OM, NSD, WF, LEW and BUF werehighly susceptible. This is inherited as a dominant characteristic and appears to be a property ofthe mammary gland rather than a systemic effect (Isaacs 1988). Also highly resistant to theinduction of mammary cancer following exposure to dust of 7,12-dimethylbenz(a)-anthracene powder applied directly to exposed mammary tissue, in contrast with WF (Takahashi et al,1992). Subtractive hybridization using COP and WF mRNAs suggested that three genes(alpha-casein, lipoprotein lipase and an unidentified gene) were over-expressed in COP mammary gland. Northern analysis also suggested that beta and gamma-casein genes were also over-expressed in resistant WKY and COP, but not in susceptible F344, WF or SD strains (Hsuand Gould, 1993). 1004
strain_drgs_chems Slow absorption of diethylstilboestrol leading to death from bladder calculi and papillomas (Dunning and Curtis 1946, Dunning et al 1947). Resistant to mammary tumour induction by7,12-dimethylbenz[a]anthracene at doses which in strains OM, NSD, WF, LEW and BUF werehighly susceptible. This is inherited as a dominant characteristic and appears to be a property ofthe mammary gland rather than a systemic effect (Isaacs 1988). Also highly resistant to theinduction of mammary cancer following exposure to dust of 7,12-dimethylbenz(a)-anthracene powder applied directly to exposed mammary tissue, in contrast with WF (Takahashi et al,1992). Subtractive hybridization using COP and WF mRNAs suggested that three genes(alpha-casein, lipoprotein lipase and an unidentified gene) were over-expressed in COP mammary gland. Northern analysis also suggested that beta and gamma-casein genes were also over-expressed in resistant WKY and COP, but not in susceptible F344, WF or SD strains (Hsuand Gould, 1993). 634612
strain_life_disease Mean life-span 20_0.2 months (but this figure is probably unreliable by modern standards). Spontaneous tumours of the thymus (Dunning and Curtis 1946, Dunning et al 1947) 1004
strain_life_disease Mean life-span 20_0.2 months (but this figure is probably unreliable by modern standards). Spontaneous tumours of the thymus (Dunning and Curtis 1946, Dunning et al 1947) 634612
strain_phys_biochem Small pituitaries (Dunning et al 1947). Resistant to Cysticercus. Will grow transplantable tumours IRS 4337 and R3327 prostate adenocarcinoma, which is a model of human prostate cancer (Lubaroff et al 1977). 1004
strain_phys_biochem Small pituitaries (Dunning et al 1947). Resistant to Cysticercus. Will grow transplantable tumours IRS 4337 and R3327 prostate adenocarcinoma, which is a model of human prostate cancer (Lubaroff et al 1977). 634612