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Strain Registration

Strain: DON

Symbol: DON
Strain: DON
Full Name: Donryu rat
RGD ID: 60996
Citation ID: RRID:RGD_60996
Ontology ID: RS:0000253
Previously known as: DONRYU
Type: inbred
Source: xx
Origin: R. Sato 1950 by inbreeding Japanese albino rats.
Genetic Markers: c
Coat Color: Albino
Inbred Generations: F59+?.
Last Known Status: Unknown

Substrains
DON/Kyo
DON/Melb






References

References - curated
# Reference Title Reference Citation
1. Genetic properties for the suppression of development of putative preneoplastic glutathione S-transferase placental form-positive foci in the liver of carcinogen-resistant DRH strain rats. Denda A, etal., Cancer Lett 1999 Jun 1;140(1-2):59-67.
2. Inbred Strains Festing, MFW, Inbred Strains, The Laboratory Rat, 1979, Baker HK, Lindsey JR, Weisbroth SH, 55-72, Academic Press
3. Update to previous Strain Data Festing, MFW, Personal Communication Update, Feb-2000
4. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_drgs_chems This is a carcinogen-sensitive strain. 625658
strain_drgs_chems When male rats were treated with N-nitrosodiethylamine and fed a diet containing 3'-Me-DAB, after 8 weeks had 30% glutathione S-transferase placental form(GST-P) positive lesions. 625658
strain_drgs_chems Relative liver weight of animals injected with N-nitrosodiethylamine(DEN)and given 3'-Me-DAB diet was greater than DRH rats treated the same way. 625658
strain_drgs_chems Relative liver weight of animals injected with N-nitrosodiethylamine(DEN) not given 3'-Me-DAB diet was less than DRH rats treated the same way. 625658
strain_infection Will accept 100% transplantable Yoshida sarcoma and ascites hepatoma (Satoh, 1964, Odashima, 1964). Corynebacterium liquefaciens induces a marked resistance to challenge with ascites hepatoma (Suzuki et al 1977). 1004
strain_infection Will accept 100% transplantable Yoshida sarcoma and ascites hepatoma (Satoh, 1964, Odashima, 1964). Corynebacterium liquefaciens induces a marked resistance to challenge with ascites hepatoma (Suzuki et al 1977). 634612
strain_life_disease Spontaneous tumours 74% in males at 120-weeks, mostly pituitary adenomas,phaeochromocytomas and insulinomas. In females incidence 89%, mostly uterineadenocarcinomas, mammary fibroadenomas and pituitary adenomas. Non-neoplastic lesions in120 week old males and females seen most commonly in the lung, cervical lymph nodes andkidneys (Maekawa et al 1986). Histiocytic sarcoma seen in 5.3% of males and 4.2% of females (Ogasawara et al, 1993). High incidence of endometrial cancer which can be inhibited by feedingindole-3-carbinol (present in cruceriferous vegitables). This may be due to the induction of estradiol 2-hydroxylation (Kojima et al, 1994). Intra-uterine administration of 20 mg/kg N-ethyl-N-nitro-N-nitrosoguanidine dissolved in polyethylene glycol resulted in 49% endometrialcarcinomas, suggesting that this rat strain provides a good animal model for endometrialadenocarcinoma in women (Andolu et al, 1994, Takahashi et al, 1995). Spontaneous endometrial cancer develops from early histological changes first observed at about six months of age associated with persistant estrus, with endometrial hyperplasia being observed at eight months. At 12 months severe hyperplasia was observed and adenocarcinomas developed from about 15 months (Nagaoka et al, 1994) 1004
strain_life_disease Spontaneous tumours 74% in males at 120-weeks, mostly pituitary adenomas,phaeochromocytomas and insulinomas. In females incidence 89%, mostly uterineadenocarcinomas, mammary fibroadenomas and pituitary adenomas. Non-neoplastic lesions in120 week old males and females seen most commonly in the lung, cervical lymph nodes andkidneys (Maekawa et al 1986). Histiocytic sarcoma seen in 5.3% of males and 4.2% of females (Ogasawara et al, 1993). High incidence of endometrial cancer which can be inhibited by feedingindole-3-carbinol (present in cruceriferous vegitables). This may be due to the induction of estradiol 2-hydroxylation (Kojima et al, 1994). Intra-uterine administration of 20 mg/kg N-ethyl-N-nitro-N-nitrosoguanidine dissolved in polyethylene glycol resulted in 49% endometrialcarcinomas, suggesting that this rat strain provides a good animal model for endometrialadenocarcinoma in women (Andolu et al, 1994, Takahashi et al, 1995). Spontaneous endometrial cancer develops from early histological changes first observed at about six months of age associated with persistant estrus, with endometrial hyperplasia being observed at eight months. At 12 months severe hyperplasia was observed and adenocarcinomas developed from about 15 months (Nagaoka et al, 1994) 634612
strain_life_disease Spontaneous tumours 74% in males at 120-w 1004
strain_life_disease Spontaneous tumours 74% in males at 120-w 634612