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Strain Registration

Strain: MNS

Symbol: MNS
Strain: MNS
Full Name: Milan normotensive strain
RGD ID: 60992
Citation ID: RRID:RGD_60992
Ontology ID: RS:0000580
Previously known as: MNS Mailand; MDC-03-45
Type: inbred
Source: Department of Sciences and Biomedical Technologies, University of Milan, Milan, Italy
Origin: Outbred Wistar rats with brother x sister mating and selection for low systolic blood pressure as a normotensive control for MHS. (Bianchi et al 1974).
Coat Color: Albino
Inbred Generations: F44
Last Known Status: Unknown





Phenotype Values via Phenominer Click to see Annotation Detail View

Related Phenotype Data for Term "MNS" (RS:0000580)

Rat Strains:
Clinical Measurements:
Experimental Conditions:
Measurement Methods:
References

References - curated
# Reference Title Reference Citation
1. Phenotypic variation in sensorimotor performance among eleven inbred rat strains. Biesiadecki BJ, etal., Am J Physiol 1999 May;276(5 Pt 2):R1383-9.
2. Locus for the inducible, but not a constitutive, nitric oxide synthase cosegregates with blood pressure in the Dahl salt-sensitive rat. Deng AY and Rapp JP, J Clin Invest 1995 May;95(5):2170-7
3. Mapping of a quantitative trait locus for blood pressure on rat chromosome 2. Deng AY, etal., J Clin Invest 1994 Jul;94(1):431-6
4. Cosegregation of blood pressure with angiotensin converting enzyme and atrial natriuretic peptide receptor genes using Dahl salt-sensitive rats. Deng Y and Rapp JP, Nat Genet 1992 Jul;1(4):267-72
5. Inbred Strains Festing, MFW, Inbred Strains, The Laboratory Rat, 1979, Baker HK, Lindsey JR, Weisbroth SH, 55-72, Academic Press
6. Update to previous Strain Data Festing, MFW, Personal Communication Update, Feb-2000
7. Genome scan and congenic strains for blood pressure QTL using Dahl salt-sensitive rats. Garrett MR, etal., Genome Res 1998 Jul;8(7):711-23
8. Genetic mapping of two blood pressure quantitative trait loci on rat chromosome 1. Gu L, etal., J Clin Invest 1996 Feb 1;97(3):777-88
9. RGD Strain RSO annotation pipeline RGD Automated Pipelines
10. SNP and haplotype mapping for genetic analysis in the rat. Saar K, etal., Nat Genet. 2008 May;40(5):560-6.

Region

Strain QTL Data
Symbol Name Trait
Bp11 Blood pressure QTL 11 blood pressure trait   (VT:0000183)    
Bp12 Blood pressure QTL 12 arterial blood pressure trait   (VT:2000000)    
Bp158 Blood pressure QTL 158 arterial blood pressure trait   (VT:2000000)    
Bp76 Blood pressure QTL 76 arterial blood pressure trait   (VT:2000000)    
Bp82 Blood pressure QTL 82 arterial blood pressure trait   (VT:2000000)    
Bp9 Blood pressure QTL 9 arterial blood pressure trait   (VT:2000000)    
Bw8 Body weight QTL 8 body mass   (VT:0001259)    
Cm51 Cardiac mass QTL 51 heart mass   (VT:0007028)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics Reviewed in relation to MHS by Bianchi et al (1984). 1004
strain_characteristics Reviewed in relation to MHS by Bianchi et al (1984). 634612
strain_life_disease An age-related glomerulosclerosis occurs in this strain, but not in MHS (Pugliese et al, 1995). This can be ameliorated but not prevented by a diet enriched in fish oil (Goldstein et al, 1995) 1004
strain_life_disease An age-related glomerulosclerosis occurs in this strain, but not in MHS (Pugliese et al, 1995). This can be ameliorated but not prevented by a diet enriched in fish oil (Goldstein et al, 1995) 634612
strain_phys_biochem At weaning, mean systolic blood pressure not different from that of MHS at about 119 mmHg, but by about 50 days the mean systolic blood pressure has only risen to 131 mmHg compared with about 170 mmHg in MHS. See MHS for more details 1004
strain_phys_biochem At weaning, mean systolic blood pressure not different from that of MHS at about 119 mmHg, but by about 50 days the mean systolic blood pressure has only risen to 131 mmHg compared with about 170 mmHg in MHS. See MHS for more details 634612
strain_phys_biochem exhibits the lowest level of sensorimotor ability (motor coordination) among the eleven strains: ACI/SegHsd, AUG/OlaHsd, BUF/NHsd, COP/Hsd, DA/OlaHsd, F344/NHsd, PVG/OlaHsd, LEW, WKY, SR/Jr, and MNS 619608