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Strain: BUF/N

Symbol: BUF/N
Strain: BUF
Substrain: N
RGD ID: 60986
RRID: RGD_60986
Ontology ID: RS:0000166
Also known as: BUF; Buffalo Rat
Type: inbred
Source: NIH Autoimmune Rat Model Repository and Development Center
Origin: Heston 1946 from Buffalo stock of H. Morris. To NIH in 1950 at F10.
Genetic Markers: a,h,c.
Coat Color: Albino.
Inbred Generations: F130
Last Known Status: Extinct





References


Region

Strain QTL Data
Symbol Name Trait
Gcr1 Gastric cancer resistance QTL 1 stomach morphology trait   (VT:0000470)    
Gcr2 Gastric cancer resistance QTL 2 stomach morphology trait   (VT:0000470)    
Gcr3 Gastric cancer resistance QTL 3 stomach morphology trait   (VT:0000470)    
Gcs1 Gastric cancer susceptibility QTL1 stomach morphology trait   (VT:0000470)    
Damaging Variants
Number of Damaging Variants
SampleRnor_6.0Rnor_5.0RGSC_v3.4
BUF/N (KNAW) 465
BUF/N (KNAW) 399
Buf/N (MCW) 1026
BUF/N (2020) 2473
BUF/N (2020)


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_drgs_chems Transplantable Morris hepatomas have been induced by several chemical agents (Morris and Wagner 1968, Morris et al 1970, Morris and Slaughter 1979). 2-acetylaminofluorine induces liver tumours in 10% of female and 70% of males and mammary tumours in 70% of females (Symeonidis 1954). Low hepatic metabolism of ethylmorphine (7/10 in males 10/10 in females), but high metabolism of anilene (3/10 males, 1/10 females) (Page and Vesell 1969). Resistant to the induction of gastric tumours by N-methyl-N-nitro- N-nitrosoguanidine (Ohgaki et al 1983). Resistant to tumour induction by 3-methylcholanthrene, 7,12-dimethylbenz(a)anthracene and trypan blue, though the former two and Bordetella pertussis vaccine induce chronic thyroiditis (Reuber and Glover1969, 1976). Resistant to the development of N-methyl-N-nitrosoguanidine (MNNG) induced gastric cancer though levels of adduct were same as in the susceptible ACI strain (Sugimura et al1995). 1004
strain_drgs_chems Transplantable Morris hepatomas have been induced by several chemical agents (Morris and Wagner 1968, Morris et al 1970, Morris and Slaughter 1979). 2-acetylaminofluorine induces liver tumours in 10% of female and 70% of males and mammary tumours in 70% of females (Symeonidis 1954). Low hepatic metabolism of ethylmorphine (7/10 in males 10/10 in females), but high metabolism of anilene (3/10 males, 1/10 females) (Page and Vesell 1969). Resistant to the induction of gastric tumours by N-methyl-N-nitro- N-nitrosoguanidine (Ohgaki et al 1983). Resistant to tumour induction by 3-methylcholanthrene, 7,12-dimethylbenz(a)anthracene and trypan blue, though the former two and Bordetella pertussis vaccine induce chronic thyroiditis (Reuber and Glover1969, 1976). Resistant to the development of N-methyl-N-nitrosoguanidine (MNNG) induced gastric cancer though levels of adduct were same as in the susceptible ACI strain (Sugimura et al1995). 634612
strain_immunology Autoimmune thyroiditis seen in 6/11 males at 36 weeks of age, but not seen in five other strains (Hajdu and Rona 1969). Spontaneous autoimmune thyroiditis with mononucelear cell infiltration of the thyroid in 26% of animals over one year (Noble et al 1976). Autoimmune thyroiditis develops spontaneously and after the ingestion of 3-methylcolanthrene, but reaches nearly 100% after neonatal thymectomy (Silverman and Rose 1975a,b). Autoimmune thyroiditis is exacerbated by high iodine diet (Cohen and Weetman 1988). Poor immune response to sheep red blood cells(6/7) (Tada et al 1974). Epitope specificities of collagen-induced studied by Cremer et al (1992).Relatively resistant to the induction of autologous immune complex nephritis (Klassen et al 1971).Poor immune response to sheep red blood cells (Tada et al 1974). A synthetic polypeptide corresponding to residues 87-99 of myelin basic protein is antigenic and encephalitogenic in these rats (Jones et al, 1992). Susceptible to the induction of EAU by interphotoreceptor retinol-binding protein (cf WKAH, W/M, LEJ and LEW, but in contrast with TO) (Sasamoto et al, 1994). Susceptible to the induction of relapsing experimental autoimmune encephalomyelitis (an animalmodel of multiple sclerosis), which can be successfully treated by an allogeneic bone marrow transplant (Van Gelder and Van Bekkum, 1995). 1004
strain_immunology Autoimmune thyroiditis seen in 6/11 males at 36 weeks of age, but not seen in five other strains (Hajdu and Rona 1969). Spontaneous autoimmune thyroiditis with mononucelear cell infiltration of the thyroid in 26% of animals over one year (Noble et al 1976). Autoimmune thyroiditis develops spontaneously and after the ingestion of 3-methylcolanthrene, but reaches nearly 100% after neonatal thymectomy (Silverman and Rose 1975a,b). Autoimmune thyroiditis is exacerbated by high iodine diet (Cohen and Weetman 1988). Poor immune response to sheep red blood cells(6/7) (Tada et al 1974). Epitope specificities of collagen-induced studied by Cremer et al (1992).Relatively resistant to the induction of autologous immune complex nephritis (Klassen et al 1971).Poor immune response to sheep red blood cells (Tada et al 1974). A synthetic polypeptide corresponding to residues 87-99 of myelin basic protein is antigenic and encephalitogenic in these rats (Jones et al, 1992). Susceptible to the induction of EAU by interphotoreceptor retinol-binding protein (cf WKAH, W/M, LEJ and LEW, but in contrast with TO) (Sasamoto et al, 1994). Susceptible to the induction of relapsing experimental autoimmune encephalomyelitis (an animalmodel of multiple sclerosis), which can be successfully treated by an allogeneic bone marrow transplant (Van Gelder and Van Bekkum, 1995). 634612
strain_infection Rapid elimination of Trichinella spiralis worms (1/12) (Bell, 1992) 1004
strain_infection Rapid elimination of Trichinella spiralis worms (1/12) (Bell, 1992) 634612
strain_life_disease Low incidence of dental caries. Spontaneous tumours of anterior pituitary 30%, and of adrenalcortex 25% in older animals. Survival 58% at 2 years of age with thyroid carcinoma in 25% (Lindsey et al 1968). Low incidence of renal neoplasms (Snell 1967). High incidence of tumours of the anterior pituitary, adrenal medulla and adrenal cortex in animals over 18 months old (Snell1965). In one line, BUF/Mna, thymomas occur spontaneously in 100% of males and 98% of females more than 18 months of age (Matasuyama et al 1986). Susceptibility appears to be dueto a single autosomal dominant locus, Tsr-1. However, this line was reported to have been independently inbred from outbred stock so may be genetically distinct from other BUF substrains (Matsuyama et al 1988). Thymoma development appears to be due to an intrinsic abnormality of the thymic epithelium as thymus rudiments transplanted to nude rats also develop similar lesions (Taguchi et al, 1992). Abnormal proliferation signals to the thymic macrophages and/or their progenitor cells may be involved in the development of thymomas (Masuda et al 1992). At the pre-thymoma stage BUF rats have extremely large thymuses due to a gene Ten-1 located on chromosome 1. This gene may be identical to Tsr-1 (Murakumo et al, 1993, 1995). High incidence of prenatal mortality (1/8=18%) early and (2/11=11%) late, but no congenital abnormalities detected (Shoji 1977). 1004
strain_life_disease Low incidence of dental caries. Spontaneous tumours of anterior pituitary 30%, and of adrenalcortex 25% in older animals. Survival 58% at 2 years of age with thyroid carcinoma in 25% (Lindsey et al 1968). Low incidence of renal neoplasms (Snell 1967). High incidence of tumours of the anterior pituitary, adrenal medulla and adrenal cortex in animals over 18 months old (Snell1965). In one line, BUF/Mna, thymomas occur spontaneously in 100% of males and 98% of females more than 18 months of age (Matasuyama et al 1986). Susceptibility appears to be dueto a single autosomal dominant locus, Tsr-1. However, this line was reported to have been independently inbred from outbred stock so may be genetically distinct from other BUF substrains (Matsuyama et al 1988). Thymoma development appears to be due to an intrinsic abnormality of the thymic epithelium as thymus rudiments transplanted to nude rats also develop similar lesions (Taguchi et al, 1992). Abnormal proliferation signals to the thymic macrophages and/or their progenitor cells may be involved in the development of thymomas (Masuda et al 1992). At the pre-thymoma stage BUF rats have extremely large thymuses due to a gene Ten-1 located on chromosome 1. This gene may be identical to Tsr-1 (Murakumo et al, 1993, 1995). High incidence of prenatal mortality (1/8=18%) early and (2/11=11%) late, but no congenital abnormalities detected (Shoji 1977). 634612
strain_phys_biochem Liver gangliosides are of the a-type (cf ACI, LEA & LEW) (Kasai et al 1993).High 10-week body weight in males (23/23) (Tanase et al 1982). 1004
strain_phys_biochem Liver gangliosides are of the a-type (cf ACI, LEA & LEW) (Kasai et al 1993).High 10-week body weight in males (23/23) (Tanase et al 1982). 634612
strain_reproduction Intermediate breeding performance (5/12) and litter size (8/12) (Hansen et al 1973). 1004
strain_reproduction Intermediate breeding performance (5/12) and litter size (8/12) (Hansen et al 1973). 634612

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-04-07 BUF/N    BUF/N    Name updated 68913 APPROVED
2015-04-07 BUF/N    BUF/N    Name updated 68913 APPROVED
2015-04-07 BUF/N    BUF/N    Name updated 68913 APPROVED
2014-11-06 BUF/N    BUF/N    Name updated 68913 APPROVED
2014-11-06 BUF/N    BUF/N    Name updated 68913 APPROVED
2013-04-15 BUF/N    BUF/N    Name updated 68913 APPROVED
2013-04-15 BUF/N    BUF/N    Name updated 68913 APPROVED
2003-11-12 BUF/N  Buffalo  BUF    Symbol Updated 728213 APPROVED