Strain Report - Rat Genome Database

Name: SS- Tgfb1 em3Mcwi+/-
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Strain Registration

General

Strain: SS-Tgfb1^em3Mcwi+/-
Symbol:	SS-Tgfb1^em3Mcwi+/-
Strain:	SS-Tgfb1^em3-/Tgfb1^em3+/-
Substrain:	Mcwi
Full Name:	SS-Tgfb1^em3Mcwi+/Tgfb1^em3Mcwi-
RGD ID:	5688119
Citation ID:	RRID:RGD_5688119
Ontology ID:	RS:0003129
Previously known as:	SS-Tgfb1em3Mcwi-/+; SS-Tgfb1em3Mcwi/2Mcwi; SS-Tgfb1^em3Mcwi/2Mcwi; SS-Tgfb1em3Mcwi-/Tgfb1em3Mcwi+; SS-Tgfb1^em3Mcwi-/Tgfb1^em3Mcwi+; SS-Tgfb1^em3Mcwi-/+
Type:	mutant
Source:	PhysGen Knockouts
Origin:	ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained heterozygous breeders.
Genetic Status:	Heterozygous
Last Known Status:	Cryopreserved Sperm (as of 2021-08-24)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

glomerulosclerosis (IMP)

proteinuria (IMP)

Tubulointerstitial Fibrosis (IMP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal urine cytokine level (IMP)

decreased transforming growth factor beta level (IMP)

decreased urine albumin level (IMP)

decreased urine protein level (IMP)

renal tubular necrosis (IMP)

Phenotype Values via PhenoMiner Click to see Annotation Detail View

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Clinical Measurement

heart rate

mean arterial blood pressure

body weight

heart wet weight

right kidney wet weight

left kidney wet weight

urine total protein excretion rate

urine albumin excretion rate

urine sodium excretion rate

urine creatinine excretion rate

References

References - curated

#	Reference Title	Reference Citation
1.	Heterozygous knockout of transforming growth factor-ß1 protects Dahl S rats against high salt-induced renal injury.	Chen CC, etal., Physiol Genomics. 2013 Feb 4;45(3):110-8. doi: 10.1152/physiolgenomics.00119.2012. Epub 2012 Dec 18.
2.	Knockout rats via embryo microinjection of zinc-finger nucleases.	Geurts AM, etal., Science. 2009 Jul 24;325(5939):433.
3.	PhysGen Knockouts	PhysGen Knockout strains
4.	RGD Strain RSO annotation pipeline	RGD Automated Pipelines

Region

Additional Information

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-08-24	SS-Tgfb1^em3Mcwi+/-	SS-Tgfb1^em3Mcwi+/Tgfb1^em3Mcwi-	SS-Tgfb1^em3Mcwi-/+	SS-Tgfb1^em3Mcwi-/Tgfb1^em3Mcwi+	Symbol and/or name change	68913	APPROVED
2014-03-31	SS-Tgfb1^em3Mcwi-/+	SS-Tgfb1^em3Mcwi-/Tgfb1^em3Mcwi+	SS-Tgfb1^em3Mcwi-/+	SS-Tgfb1^em3Mcwi-/Tgfb1^em3Mcwi+	Symbol and/or name change	68913	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Strain: SS-Tgfb1^em3Mcwi+/-

Mammalian Phenotype

Related Phenotype Data for Term "SS-Tgfb1em3Mcwi+/-" (RS:0003129)

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Strain: SS-Tgfb1em3Mcwi+/-

Mammalian Phenotype

Related Phenotype Data for Term "SS-Tgfb1em3Mcwi+/-" (RS:0003129)

Strain: SS-Tgfb1^em3Mcwi+/-