Strain Report - Rat Genome Database

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Strain: SS-Ncf2em1Mcwi-/-

Symbol: SS-Ncf2em1Mcwi-/-
Strain: SS-Ncf2em1-/Ncf2em1-
Substrain: Mcwi
Full Name: SS-Ncf2em1Mcwi-/Ncf2em1Mcwi-
RGD ID: 5688066
Citation ID: RRID:RGD_5688066
Ontology ID: RS:0003149
Alleles: Ncf2em1Mcwi
Previously known as: SS-Ncf2em1Mcwi-/-; SS-Ncf2em1Mcwi/1Mcwi; SS-Ncf2em1Mcwi/1Mcwi; SS-Ncf2em1Mcwi-/Ncf2em3Mcwi-
Type: mutant
Source: PhysGen Knockouts
Origin: ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders.
Genetic Status: Homozygous
Last Known Status: Live Animals; Cryopreserved Sperm (as of 2018-09-05)
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21364,958,217 - 64,958,221RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01370,229,196 - 70,229,200RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01375,200,283 - 75,200,287RGD_MAPPER_PIPELINERnor5.0
Rnor_5.01375,200,283 - 75,200,287RGD_MAPPER_PIPELINERnor5.0
Rnor_5.01375,200,283 - 75,200,287RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41367,806,516 - 67,834,105RGD_MAPPER_PIPELINERGSC3.4


References - curated
# Reference Title Reference Citation
1. Increased expression of NAD(P)H oxidase subunit p67(phox) in the renal medulla contributes to excess oxidative stress and salt-sensitive hypertension. Feng D, etal., Cell Metab. 2012 Feb 8;15(2):201-8. doi: 10.1016/j.cmet.2012.01.003.
2. Knockout rats via embryo microinjection of zinc-finger nucleases. Geurts AM, etal., Science. 2009 Jul 24;325(5939):433.
3. PhysGen Knockouts PhysGen Knockout strains
4. RGD Strain RSO annotation pipeline RGD Automated Pipelines


Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Ncf2em1Mcwi-var1 chr13 64958217 64958221 GAGAA - deletion mRatBN7.2
Ncf2em1Mcwi-var1 chr13 70229196 70229200 GAGAA - deletion Rnor_6.0
Ncf2em1Mcwi-var1 chr13 75200283 75200287 GAGAA - deletion Rnor_5.0

Additional Information

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-03-31 SS-Ncf2em1Mcwi-/-  SS-Ncf2em1Mcwi-/Ncf2em1Mcwi-  SS-Ncf2em1Mcwi-/-  SS-Ncf2em1Mcwi-/Ncf2em1Mcwi-  Symbol and/or name change 68913 APPROVED