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Strain Registration

Strain: SS-Sh2b3em2Mcwi-/-

Symbol: SS-Sh2b3em2Mcwi-/-
Strain: SS-Sh2b3em2-/Sh2b3em2-
Substrain: Mcwi
Full Name: SS-Sh2b3em2Mcwi-/Sh2b3em2Mcwi-
RGD ID: 5686766
Citation ID: RRID:RGD_5686766
Ontology ID: RS:0003092
Alleles: Sh2b3em2Mcwi
Previously known as: SS-Sh2b3em2Mcwi-/-; SS-Sh2b3em2Mcwi/1Mcwi; SS-Sh2b3em2Mcwi/1Mcwi; SS-Sh2b3em2Mcwi-/Sh2b3em2Mcwi-
Type: mutant
Source: PhysGen Knockouts
Origin: ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders.
Genetic Status: Homozygous
Last Known Status: Cryopreserved Sperm (as of 2021-11-03)
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21234,750,773 - 34,750,773RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01240,261,990 - 40,265,757RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01242,132,947 - 42,136,714RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41235,954,679 - 35,958,446RGD_MAPPER_PIPELINERGSC3.4





References

References - curated
# Reference Title Reference Citation
1. SH2B3 Is a Genetic Determinant of Cardiac Inflammation and Fibrosis. Flister MJ, etal., Circ Cardiovasc Genet. 2015 Apr;8(2):294-304. doi: 10.1161/CIRCGENETICS.114.000527. Epub 2015 Jan 27.
2. Knockout rats via embryo microinjection of zinc-finger nucleases. Geurts AM, etal., Science. 2009 Jul 24;325(5939):433.
3. PhysGen Knockouts PhysGen Knockout strains
4. RGD Strain RSO annotation pipeline RGD Automated Pipelines
5. Creation and preliminary characterization of a leptin knockout rat. Vaira S, etal., Endocrinology. 2012 Nov;153(11):5622-8. doi: 10.1210/en.2012-1462. Epub 2012 Sep 4.

Region

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Sh2b3em2Mcwi-var1 chr12 34750773 34750773 A - deletion mRatBN7.2

Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-03-27 SS-Sh2b3em2Mcwi-/-  SS-Sh2b3em2Mcwi-/Sh2b3em2Mcwi-  SS-Sh2b3em2Mcwi-/-  SS-Sh2b3em2Mcwi-/Sh2b3em2Mcwi-  Symbol and/or name change 68913 APPROVED