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Strain Registration

Strain: SS-Ncf2em1Mcwi

Symbol: SS-Ncf2em1Mcwi
Strain: SS-Ncf2em1
Substrain: Mcwi
RGD ID: 5144104
Citation ID: RRID:RGD_5144104
Ontology ID: RS:0002638
Alleles: Ncf2em1Mcwi
Also Known As: SS-Ncf2em1Mcwi; p67phox-/-; SS-Ncf2^[em1Mcwi]
Type: mutant
Available Source: Not Available
Origination: PhysGen Knockouts
Description: This strain was produced by injecting ZFNs targeting the sequence CTCTACTACAGCATGgagaagTAAGTGGTGTCGGAGTGT into SS/JrHsdMcwi rat embryos. The resulting mutation is a 5-bp frameshift deletion in exon 2.
Last Known Status: Live Animals; Cryopreserved Sperm (as of 2017-01-26)
Genotyping Protocol Download Genotyping Protocol
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21364,958,217 - 64,958,221RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01370,229,196 - 70,229,200RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01375,200,283 - 75,200,287RGD_MAPPER_PIPELINERnor5.0
Rnor_5.01375,200,283 - 75,200,287RGD_MAPPER_PIPELINERnor5.0
Rnor_5.01375,200,283 - 75,200,287RGD_MAPPER_PIPELINERnor5.0
Rnor_5.01375,200,283 - 75,200,287RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41367,806,516 - 67,834,105RGD_MAPPER_PIPELINERGSC3.4





Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. Increased expression of NAD(P)H oxidase subunit p67(phox) in the renal medulla contributes to excess oxidative stress and salt-sensitive hypertension. Feng D, etal., Cell Metab. 2012 Feb 8;15(2):201-8. doi: 10.1016/j.cmet.2012.01.003.
2. Knockout rats via embryo microinjection of zinc-finger nucleases. Geurts AM, etal., Science. 2009 Jul 24;325(5939):433.
3. PhysGen Knockouts PhysGen Knockout strains
4. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Ncf2em1Mcwi-var1 chr13 64958217 64958221 GAGAA - deletion mRatBN7.2
Ncf2em1Mcwi-var1 chr13 70229196 70229200 GAGAA - deletion Rnor_6.0
Ncf2em1Mcwi-var1 chr13 75200283 75200287 GAGAA - deletion Rnor_5.0
Ncf2em1Mcwi-var1 chr13 75200283 75200287 GAGAA - deletion Rnor_5.0

Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-03-26 SS-Ncf2em1Mcwi    SS-Ncf2em1Mcwi    Symbol updated 68687 APPROVED
2014-03-26 SS-Ncf2em1Mcwi    SS-Ncf2em1Mcwi    Symbol updated 68687 APPROVED
2014-03-26 SS-Ncf2em1Mcwi    SS-Ncf2em1Mcwi    Name updated 68913 APPROVED
2014-03-26 SS-Ncf2em1Mcwi    SS-Ncf2em1Mcwi    Name updated 68913 APPROVED
2013-08-14 SS-Ncf2em1Mcwi    SS-Ncf2em1Mcwi    Name updated 68913 APPROVED
2013-08-14 SS-Ncf2em1Mcwi    SS-Ncf2em1Mcwi    Name updated 68913 APPROVED