Strain Report - Rat Genome Database

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Strain: SS-Plekha7em4Mcwi

Symbol: SS-Plekha7em4Mcwi
Strain: SS-Plekha7em4
Substrain: Mcwi
RGD ID: 5143995
Citation ID: RRID:RGD_5143995
Ontology ID: RS:0002633
Alleles: Plekha7em4Mcwi
Also Known As: SS-Plekha7em4Mcwi; SS-Plekha7^[em4Mcwi]
Type: mutant
Available Source: Not Available
Origination: PhysGen Knockouts
Description: This strain was produced by injecting ZFNs targeting the sequence CCTCTGCCCAGCTACgtcatcTCCCCGGTGGCCCCCGAG into SS/JrHsdMcwi rat embryos. The resulting mutation is a 19-bp frameshift deletion in exon 8.
Last Known Status: Live Animals; Cryopreserved Sperm (as of 2017-01-26)
Genotyping Protocol Download Genotyping Protocol
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21170,420,191 - 170,420,209RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01185,483,638 - 185,483,656RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01192,397,589 - 192,463,974RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41174,249,022 - 174,316,226RGD_MAPPER_PIPELINERGSC3.4






References

References - curated
# Reference Title Reference Citation
1. Mutation of Plekha7 attenuates salt-sensitive hypertension in the rat. Endres BT, etal., Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12817-22. doi: 10.1073/pnas.1410745111. Epub 2014 Aug 18.
2. Knockout rats via embryo microinjection of zinc-finger nucleases. Geurts AM, etal., Science. 2009 Jul 24;325(5939):433.
3. PhysGen Knockouts PhysGen Knockout strains
4. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Plekha7em4Mcwi-var1 chr1 170420191 170420209 GTCATCTCCCCGGTGGCCC - deletion mRatBN7.2
Plekha7em4Mcwi-var1 chr1 185483638 185483656 GTCATCTCCCCGGTGGCCC - deletion Rnor_6.0

Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-03-26 SS-Plekha7em4Mcwi    SS-Plekha7em4Mcwi    Symbol updated 68687 APPROVED
2014-03-26 SS-Plekha7em4Mcwi    SS-Plekha7em4Mcwi    Symbol updated 68687 APPROVED
2014-03-26 SS-Plekha7em4Mcwi    SS-Plekha7em4Mcwi    Name updated 68913 APPROVED
2014-03-26 SS-Plekha7em4Mcwi    SS-Plekha7em4Mcwi    Name updated 68913 APPROVED
2013-08-14 SS-Plekha7em4Mcwi    SS-Plekha7em4Mcwi    Name updated 68913 APPROVED
2013-08-14 SS-Plekha7em4Mcwi    SS-Plekha7em4Mcwi    Name updated 68913 APPROVED