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Strain Registration

Strain: SS-Alms1em1Mcwi

Symbol: SS-Alms1em1Mcwi
Strain: SS-Alms1em1
Substrain: Mcwi
RGD ID: 5131911
Citation ID: RRID:RGD_5131911
Ontology ID: RS:0002579
Alleles: Alms1em1Mcwi
Also Known As: SS-Alms1em1Mcwi; SS-Alms1^[em1Mcwi]
Type: mutant
Available Source: Not Available
Origination: PhysGen Knockouts
Description: This strain was produced by injecting ZFNs targeting the sequence CCCGCCTCCGACTCCGCCtccgtcCTCCCGGCACCAGTA into SS/JrHsdMcwi rat embryos. The resulting mutation is a 17-bp frameshift deletion in exon 1.
Last Known Status: Cryopreserved Sperm (as of 2017-01-26)
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24118,125,581 - 118,226,005RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.04117,371,972 - 117,371,988RGD_MAPPER_PIPELINERnor6.0
Rnor_5.04181,947,469 - 182,048,235RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.44119,846,037 - 119,946,085RGD_MAPPER_PIPELINERGSC3.4






References

References - curated
# Reference Title Reference Citation
1. Knockout rats via embryo microinjection of zinc-finger nucleases. Geurts AM, etal., Science. 2009 Jul 24;325(5939):433.
2. Role of Alström syndrome 1 in the regulation of blood pressure and renal function. Jaykumar AB, etal., JCI Insight. 2018 Nov 2;3(21). pii: 95076. doi: 10.1172/jci.insight.95076.
3. Role of Alström syndrome 1 in the regulation of glomerular hemodynamics. Monu SR, etal., Am J Physiol Renal Physiol. 2023 Oct 1;325(4):F418-F425. doi: 10.1152/ajprenal.00017.2023. Epub 2023 Aug 10.
4. PhysGen Knockouts PhysGen Knockout strains
5. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Alms1em1Mcwi-var1 chr4 117371972 117371988 CTCCGTCCTCCCGGCAC - deletion Rnor_6.0

Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-03-25 SS-Alms1em1Mcwi    SS-Alms1em1Mcwi    Symbol updated 68687 APPROVED
2014-03-25 SS-Alms1em1Mcwi    SS-Alms1em1Mcwi    Name updated 68913 APPROVED
2014-03-25 SS-Alms1em1Mcwi    SS-Alms1em1Mcwi    Symbol updated 68687 APPROVED
2014-03-25 SS-Alms1em1Mcwi    SS-Alms1em1Mcwi    Name updated 68913 APPROVED
2013-08-13 SS-Alms1em1Mcwi    SS-Alms1em1Mcwi    Name updated 68913 APPROVED
2013-08-13 SS-Alms1em1Mcwi    SS-Alms1em1Mcwi    Name updated 68913 APPROVED
2013-03-21 SS-Alms1em1Mcwi    SS-Alms1em1Mcwi    Name updated 68913 APPROVED
2013-03-21 SS-Alms1em1Mcwi    SS-Alms1em1Mcwi    Name updated 68913 APPROVED