Strain Report - Rat Genome Database

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Strain: WLI/EerRrrc

Symbol: WLI/EerRrrc
Strain: WLI
Substrain: EerRrrc
Full Name: WKY least immobile
RGD ID: 4891107
Citation ID: RRID:RRRC_00967
Ontology ID: RS:0000720
Also Known As: RRRC:00967; WLI/Eer
Type: inbred
Available Source: Rat Resource and Research Center
Origination: Dept. of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois
Description: 3 pairs of WKY males and females with lowest immobility and highest climbing scores in the forced swim test were mated.
Last Known Status: Unknown






References

References - curated
# Reference Title Reference Citation
1. Gene expression patterns in the hippocampus and amygdala of endogenous depression and chronic stress models. Andrus BM, etal., Mol Psychiatry. 2010 Nov 16.
2. Blood transcriptomic markers for major depression: from animal models to clinical settings. Redei EE and Mehta NS, Ann N Y Acad Sci. 2015 Mar 30. doi: 10.1111/nyas.12748.
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines
4. Selectively bred Wistar-Kyoto rats: an animal model of depression and hyper-responsiveness to antidepressants. Will CC, etal., Mol Psychiatry. 2003 Nov;8(11):925-32.

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics Under restraint stress males have lower plasma CORT response than WMI/Eer males 4891104
strain_characteristics In the open field test these cross more lines than WMI/Eer 4891104
strain_other Between WMI/Eer and WLI/Eer strains there are 638 genes in amygdala and 463 genes in hippocampus that are differentially expressed; whereas only Kcnj14 and Mprl9 in amygdala and Chi3l1, Col1a1, Mmp14 and RGD1305680 in the hippocampus show differential expression both in chronic stress response and endogenous depression 4891105

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-11-03 WLI/EerRrrc  WKY least immobile  WLI/Eer  WKY least immobile  Symbol and/or name change 68913 APPROVED

Database Acc Id Source(s)
RRRC RRRC:00967 RGD