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Strain Registration

Strain: DA.PVG.1AV1-(D17Rat8-D17Rat37)/Kini

Symbol: DA.PVG.1AV1-(D17Rat8-D17Rat37)/Kini
Strain: DA.PVG.1AV1-(D17Rat8-D17Rat37)
Substrain: Kini
RGD ID: 4889890
Citation ID: RRID:RGD_4889890
Ontology ID: RS:0002506
Also Known As: DA.PVG.1AV1-Eae23; NBRP Rat No: 0679; DA.PVG.1AV1-(D17Rat8-D17Rat37)/Kini; DA.PVG-Eae23; DA.PVG-Eae23
Type: congenic
Available Source: National BioResource Project for the Rat in Japan
Origination: Center for Molecular Medicine, Neuroimmunology Unit, Karolinska Institutet, Stockholm, Sweden
Description: DA/ZtmKini females were mated with PVG.1AV1/Kini males and offsprings were selected for the PVG allele of interest, one breeding pair from N8 generation was intercrossed to give homozygous congenic that had PVG allele from D17Rat8 to D17Rat37
Coat Color: Agouti
Last Known Status: Cryopreserved Sperm
Research Usage Immunology
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21721,782,841 - 64,759,263RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01723,522,321 - 68,114,865RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01725,486,196 - 69,844,594RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41727,618,789 - 75,802,944RGD_MAPPER_PIPELINERGSC3.4





Experimental Data Annotations    Click to see Annotation Detail View

Rat Strain
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
DA.PVG.1AV1-(D17Rat8-D17Rat37)/KiniRatDA.PVG.1AV1-(D17Rat8-D17Rat37)/Kini  IEA 7241799 RGD 

Vertebrate Trait
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
DA.PVG.1AV1-(D17Rat8-D17Rat37)/KiniRatnervous system integrity trait  EXP 629629 RGD 

References

References - curated
# Reference Title Reference Citation
1. New loci regulating rat myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis. Becanovic K, etal., J Immunol 2003 Jan 15;170(2):1062-9.
2. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines
4. Fine-mapping resolves Eae23 into two QTLs and implicates ZEB1 as a candidate gene regulating experimental neuroinflammation in rat. Stridh P, etal., PLoS One. 2010 Sep 15;5(9):e12716.

Region

Position Markers

Flank 1 / 1 (D17Rat8)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21721,782,841 - 21,783,009 (-)MAPPER
Rnor_6.01723,522,321 - 23,522,488NCBI
Rnor_5.01725,486,196 - 25,486,363UniSTS
RGSC_v3.41727,618,789 - 27,619,178RGD
RGSC_v3.41727,619,001 - 27,619,168UniSTS
RGSC_v3.11727,621,842 - 27,622,009RGD
RH 3.4 Map17268.8UniSTS
RH 3.4 Map17268.8RGD
RH 2.0 Map17185.2RGD
SHRSP x BN Map1713.92RGD
FHH x ACI Map1719.0399RGD
Cytogenetic Map17p12UniSTS

Flank 2 / 1 (D17Rat37)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21764,759,096 - 64,759,263 (+)MAPPER
Rnor_6.01768,114,699 - 68,114,865NCBI
Rnor_5.01769,844,428 - 69,844,594UniSTS
RGSC_v3.41775,802,562 - 75,802,944RGD
RGSC_v3.41775,802,563 - 75,802,729UniSTS
RGSC_v3.11775,813,395 - 75,813,777RGD
Celera1764,336,181 - 64,336,347UniSTS
RH 2.0 Map17584.5RGD
SHRSP x BN Map1734.8699RGD
FHH x ACI Map1744.4RGD
Strain QTL Data
Symbol Name Trait
Eae33 Experimental allergic encephalomyelitis QTL 33 nervous system integrity trait   (VT:0010566)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics Partial protection against experimental autoimmune encephalomyelitis (EAE) compared to the susceptible parental DA strain (no significant difference in susceptibility (INC and ONS), but DA.PVG-Eae23 rats had lower severity. CNS has increased level of Foxp3 positive cells. 1302502
strain_life_disease CNS has increased level of Foxp3 positive cells that helped in the disease amelioration 4889889
strain_reproduction Good breeding performance. 1302502

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-04-18 DA.PVG.1AV1-(D17Rat8-D17Rat37)/Kini    DA.PVG.1AV1-(D17Rat8-D17Rat37)/Kini    Name updated 68913 APPROVED
2014-04-18 DA.PVG.1AV1-(D17Rat8-D17Rat37)/Kini    DA.PVG.1AV1-(D17Rat8-D17Rat37)/Kini    Name updated 68913 APPROVED
2010-12-09 DA.PVG.1AV1-(D17Rat8-D17Rat37)/Kini    DA.PVG.1AV1-(D17Rat113-D17Rat97)/Kini    Name updated 68913 APPROVED
2010-12-09 DA.PVG.1AV1-(D17Rat8-D17Rat37)/Kini    DA.PVG.1AV1-(D17Rat113-D17Rat97)/Kini    Name updated 68913 APPROVED
2010-12-09 DA.PVG.1AV1-(D17Rat8-D17Rat37)/Kini    DA.PVG.1AV1-(D17Rat113-D17Rat97)/Kini    Symbol updated 68687 APPROVED
2010-12-09 DA.PVG.1AV1-(D17Rat113-D17Rat97)/Kini    DA.PVG.1AV1-(D17Rat113-D17Rat97)/Kini    Name updated 68913 APPROVED
2010-12-09 DA.PVG.1AV1-(D17Rat8-D17Rat37)/Kini    DA.PVG.1AV1-(D17Rat113-D17Rat97)/Kini    Symbol updated 68687 APPROVED