Strain Report - Rat Genome Database

Name: GK/Ox
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Strain Registration

General

Strain: GK/Ox
Symbol:	GK/Ox
Strain:	GK
Substrain:	Ox
RGD ID:	4889464
Citation ID:	RRID:RGD_4889464
Ontology ID:	RS:0002495
Previously known as:	GK/Ox
Type:	inbred
Source:	The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
Origin:	Original breeders are from a colony in Paris (CNRS URA 307, Paris, France) which were obtained in 1995 and since then bred locally in Oxford, UK
Last Known Status:	Unknown

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

hyperglycemia (IAGP)

Insulin Resistance (IAGP)

type 2 diabetes mellitus (IAGP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

decreased insulin secretion (IAGP)

decreased pancreatic beta cell mass (IAGP)

decreased prolactin level (IAGP)

impaired glucose tolerance (IAGP)

increased body weight (IAGP)

increased circulating corticosterone level (IAGP)

increased circulating glucose level (IAGP)

increased circulating HDL cholesterol level (IAGP)

increased circulating insulin level (IAGP)

increased circulating insulin-like growth factor I level (IAGP)

increased circulating phospholipid level (IAGP)

increased circulating VLDL cholesterol level (IAGP)

increased fasting circulating glucose level (IAGP)

increased prolactin level (IAGP)

insulin resistance (IAGP)

Phenotype Values via PhenoMiner Click to see Annotation Detail View

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Clinical Measurement

body weight

plasma glucose level

plasma insulin level

plasma corticosterone level

plasma growth hormone level

plasma insulin-like growth factor 1 level

ratio of insulin-positive cell area to total area of duodenal region of pancreas

ratio of insulin-positive cell area to total area of splenic region of pancreas

calculated total pancreatic islet beta cell weight

duodenal region pancreatic beta cell weight calculated as the product of pancreas duodenal region weight and corresponding beta cell fractional area

splenic region pancreatic beta cell weight calculated as the product of pancreas splenic region weight and corresponding beta cell fractional area

plasma prolactin level

References

References - curated

#	Reference Title	Reference Citation
1.	Mapping diabetes QTL in an intercross derived from a congenic strain of the Brown Norway and Goto-Kakizaki rats.	Collins SC, etal., Mamm Genome. 2006 Jun;17(6):538-47. Epub 2006 Jun 12.
2.	Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models.	Dumas ME, etal., Nat Genet. 2007 Apr 15;.
3.	Chromosomal mapping of pancreatic islet morphological features and regulatory hormones in the spontaneously diabetic (Type 2) Goto-Kakizaki rat.	Finlay C, etal., Mamm Genome. 2010 Oct;21(9-10):499-508. Epub 2010 Sep 29.
4.	Chromosomal mapping of genetic loci associated with non-insulin dependent diabetes in the GK rat	Gauguier D, etal., Nat Genet 1996 Jan;12(1):38-43
5.	RGD Strain RSO annotation pipeline	RGD Automated Pipelines
6.	Pathophysiological, genetic and gene expression features of a novel rodent model of the cardio-metabolic syndrome.	Wallis RH, etal., PLoS ONE. 2008 Aug 13;3(8):e2962.

Region

Strain QTL Data

Symbol	Name	Trait
Niddm67	Non-insulin dependent diabetes mellitus QTL 67	blood glucose amount (VT:0000188)
Niddm69	Non-insulin dependent diabetes mellitus QTL 69	blood insulin amount (VT:0001560)
Pancm2	Pancreatic morphology QTL 2	pancreatic beta cell morphology trait (VT:0005217)
Scort2	Serum corticosterone level QTL 2	blood corticosterone amount (VT:0005345)

Damaging Variants

	Number of Damaging Variants
Sample	mRatBN7.2	Rnor_6.0	Rnor_5.0	RGSC_v3.4
GK/Ox (ICL)				717
GK/Ox (KNAW)			926
GK/Ox (RGD)		1079

Additional Information

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Strain: GK/Ox

Mammalian Phenotype

Related Phenotype Data for Term "GK/Ox" (RS:0002495)