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Strain: WI- Lpar1m1Hubr

Symbol: WI- Lpar1m1Hubr
Strain: WI- Lpar1m1
Substrain: Hubr
RGD ID: 39457945
Citation ID: RRID:RGD_39457945
Ontology ID: RS:0004925
Alleles: Lpar1m1Hubr
Type: mutant
Source: Hubrecht Laboratory, Centre for Biomedical Genetics, 3584 CT Utrecht, The Netherlands. Hera Biolabs, Taconic.
Origin: The Lpar1 mutant rat line was generated by target-selected ENU-driven mutagenesis of male MSH6 knockout rats, and high-throughput resequencing of genomic target sequences in progeny from mutagenized rats revealed an ENU-induced missense mutation in Lpar1 that resulted in the change of a methionine into an arginine (p.M318R) in the 8th helix and that was predicted to be deleterious for protein function.
Last Known Status: Unknown
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2573,229,047 - 73,347,874RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0575,557,038 - 75,678,067RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0579,707,131 - 79,825,313RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4576,449,470 - 76,571,458RGD_MAPPER_PIPELINERGSC3.4

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Mammalian Phenotype


References - curated
# Reference Title Reference Citation
1. Systematic generation of in vivo G protein-coupled receptor mutants in the rat. van Boxtel R, etal., Pharmacogenomics J. 2011 Oct;11(5):326-36. doi: 10.1038/tpj.2010.44. Epub 2010 Jun 8.


Additional Information