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Strain Registration

Strain: SD.BN-Aireem1Ang-/-

Symbol: SD.BN-Aireem1Ang-/-
Strain: SD.BN-Aireem1-/-
Substrain: Ang
RGD ID: 38599147
Citation ID: RRID:RGD_38599147
Ontology ID: RS:0004815
Alleles: Aireem1Ang
Also Known As: Aire-/-SPD; SD.BN-Aire^[em1Ang-/-]
Type: mutant
Available Source: Not Available
Origination: Centre de Recherche en Transplantation et Immunologie UMR 1064, ITUN, 30 Boulevard Jean Monnet, 44093 Nantes Cedex 01, France
Description: The BN homozygous Aire mutant rats were derived from founder rats that were backcrossed in a Sprague Dawley (SD; outbred strain) background for six generations to obtain AIRE-deficient SD rats. The original founder were from BN mutants carrying the mutations created by ZFN reagents targeting to a DNA sequence 59-TGCCACCCAGACCCCCCACAAAGAGAAGAGCCCTGGAAGAG- 39 in exon 3 of the Aire gene. This mutant carriesa 17-bp deletion in the nuclear localization signal sequence, causing a premature stop codon.
Genetic Status: Homozygous
Last Known Status: Unknown
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22010,636,058 - 10,651,060RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.02011,365,630 - 11,380,636RGD_MAPPER_PIPELINERnor6.0
Rnor_5.02013,535,776 - 13,550,486RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.42010,980,031 - 10,996,102RGD_MAPPER_PIPELINERGSC3.4





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References

References - curated
# Reference Title Reference Citation
1. Breakdown of Immune Tolerance in AIRE-Deficient Rats Induces a Severe Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy-like Autoimmune Disease. Ossart J, etal., J Immunol. 2018 Aug 1;201(3):874-887. doi: 10.4049/jimmunol.1701318. Epub 2018 Jun 29.

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