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Strain Registration

Strain: SD-Rag2em1Hera

Symbol: SD-Rag2em1Hera
Strain: SD-Rag2em1Hera
Substrain: Hera
RGD ID: 38543943
Citation ID: RRID:RGD_38543943
Ontology ID: RS:0004805
Also Known As: SD-Rag2^[em1Hera]
Type: mutant
Available Source: Not Available
Description: The Rag2 gene in rat spermatogonia stem cells (SSC, SD-WT2) was targeted by TALENs and resulted in a 27-bp in-frame deletion. The genome modified SSC was transplanted to Busulfan-treated, Dazl-deficient male Sprague Dawley rats and mated with wild type female Sprague Dawley rats 70 to 81 later. The allele was then bred to homozygosity to generate the Sprague-Dawley Rag2 (SDR)-knockout rat.
Genetic Status: Homozygous
Last Known Status: Unknown





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References

References - curated
# Reference Title Reference Citation
1. Sprague Dawley Rag2-Null Rats Created from Engineered Spermatogonial Stem Cells Are Immunodeficient and Permissive to Human Xenografts. Noto FK, etal., Mol Cancer Ther. 2018 Nov;17(11):2481-2489. doi: 10.1158/1535-7163.MCT-18-0156. Epub 2018 Sep 11.

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