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Strain Registration

Strain: SD-Bmpr2em1Ang+/-

Symbol: SD-Bmpr2em1Ang+/-
Strain: SD-Bmpr2em1
Substrain: Ang
RGD ID: 38501086
Citation ID: RRID:RGD_38501086
Ontology ID: RS:0004804
Alleles: Bmpr2em1Ang
Also Known As: BMPR2Δ140Ex1/+; SD-Bmpr2^[em1Ang+/-]
Type: mutant
Available Source: Not Available
Description: BMPR2-deficient rats were generated by using zinc-finger nucleases (Sigma, St. Louis, MO). The mRNA encoding mRNA at 5 ng/μL encoding a pair of zinc-finger nucleases recognizing rat BMPR2 sequences was injected to the cytoplasm of Sprague-Dawley zygotes. A rat line with a heterozygous 140 base pairs deletion in the first exon (BMPR2Δ140Ex1/+ rats) was chosen for this study becauseit displayed an intense pulmonary vascular remodeling at 3 months of life that was absent in the wild-type littermates.
Genetic Status: Heterozygous
Last Known Status: Unknown
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2961,192,718 - 61,307,280RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0966,568,074 - 66,683,019RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0966,371,542 - 66,486,121RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4958,327,587 - 58,436,057RGD_MAPPER_PIPELINERGSC3.4





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Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. Endothelial-to-mesenchymal transition in pulmonary hypertension. Ranchoux B, etal., Circulation. 2015 Mar 17;131(11):1006-18. doi: 10.1161/CIRCULATIONAHA.114.008750. Epub 2015 Jan 15.

Region


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