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Strain Registration

Strain: WKY-Col4a5em3Matsu

Symbol: WKY-Col4a5em3Matsu
Strain: WKY-Col4a5em3
Substrain: Matsu
RGD ID: 329845600
Citation ID: RRID:RGD_329845600
Ontology ID: RS:0005270
Alleles: Col4a5em3Matsu
Also Known As: NBRP Rat No: 0964; Col4a 56bp deletion; WKY-Col4a5^[em3Matsu]
Type: mutant
Available Source: National BioResource Project for the Rat in Japan
Origination: Division of Molecular Genetics, Shigei Medical Research Institute, 2117 Yamada, Minami-ku, Okayama, 701-0202, Japan
Description: Genome editing was performed using the rGONAD method to produce three different lines of KO rats due to three different genome mutations thus different in protein expression predication. The genetic background is WKY/NCrlCrlj (Charles River Laboratories Japan) (RGD:61119). Tandem STOP codons were designed to integrate into 27 bases after the first ATG in the rat Col4a5 gene This em3 mutant carries a deletion of 56 base pairs containing the first methioine. Col4α5 em3 ratshave urinary protein and hematuria from early on, and males begin to die at 18 weeks of age and all die by 28 weeks of age.
Last Known Status: Unknown
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X105,118,762 - 105,322,699RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0X112,769,595 - 112,983,720RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0X111,226,503 - 111,437,171RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4X36,918,697 - 37,130,659RGD_MAPPER_PIPELINERGSC3.4





Disease Annotations     Click to see Annotation Detail View
proteinuria  (IMP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. Creation of X-linked Alport syndrome rat model with Col4a5 deficiency. Namba M, etal., Sci Rep. 2021 Oct 21;11(1):20836. doi: 10.1038/s41598-021-00354-y.
2. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP

Region


Additional Information