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Strain Registration

Strain: SHR.BN-(D3Rat159-D3Rat1)/Mco

Symbol: SHR.BN-(D3Rat159-D3Rat1)/Mco
Strain: SHR.BN-(D3Rat159-D3Rat1)
Substrain: Mco
RGD ID: 2316925
Citation ID: RRID:RGD_2316925
Ontology ID: RS:0002376
Also Known As: SHR.BN-(D3Rat159-D3Rat1)/Mco; SHR.BN3
Type: congenic
Available Source: Not Available
Origination: Medical College of Ohio, Toledo, Ohio, USA
Description: 50.6 Mb region of BN/SsNHsd is introgressed into the genomic background of SHR/NHsd
Last Known Status: Unknown
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23118,950,053 - 168,026,850RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.03124,284,647 - 176,418,101RGD_MAPPER_PIPELINERnor6.0
Rnor_5.03130,776,038 - 180,128,021RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.43119,437,175 - 170,016,653RGD_MAPPER_PIPELINERGSC3.4





Disease Annotations     Click to see Annotation Detail View
Hyperplasia  (IAGP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. Neointimal hyperplasia and vasoreactivity are controlled by genetic elements on rat chromosome 3. Nestor Kalinoski AL, etal., Hypertension. 2010 Feb;55(2):555-61. Epub 2009 Dec 21.
2. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Position Markers

Flank 1 / 1 (D3Rat159)
Rat AssemblyChrPosition (strand)Source
mRatBN7.23118,950,053 - 118,950,296 (+)MAPPER
Rnor_6.03124,284,647 - 124,284,889NCBI
Rnor_5.03130,776,038 - 130,776,280UniSTS
RGSC_v3.43119,437,175 - 119,437,418RGD
RGSC_v3.43119,437,176 - 119,437,418UniSTS
RGSC_v3.13119,342,636 - 119,343,133RGD
Celera3117,753,526 - 117,753,768UniSTS
SHRSP x BN Map358.5499RGD
SHRSP x BN Map358.5499UniSTS

Flank 2 / 1 (D3Rat1)
Rat AssemblyChrPosition (strand)Source
mRatBN7.23168,026,691 - 168,026,850 (+)MAPPER
Rnor_6.03176,417,943 - 176,418,101NCBI
Rnor_5.03180,127,863 - 180,128,021UniSTS
RGSC_v3.43170,016,309 - 170,016,467UniSTS
RGSC_v3.43170,016,252 - 170,016,653RGD
RGSC_v3.13169,922,345 - 169,922,503RGD
Celera3164,558,222 - 164,558,366UniSTS
RH 3.4 Map31533.2RGD
RH 3.4 Map31533.2UniSTS
RH 2.0 Map31027.1RGD
SHRSP x BN Map391.5299RGD
FHH x ACI Map3104.89RGD
Cytogenetic Map3q43UniSTS

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics These have rapid and sustained vasoconstriction as compared to parental SHR 2316923
strain_life_disease 3-fold increase in the percent of neointimal hyperplasia was seen in these rats as compared to parental SHR 2316923

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-03-02 SHR.BN-(D3Rat159-D3Rat1)/Mco    SHR.BN-(D3Rat159-D3Rat1)/Mco    Name updated 68913 APPROVED
2010-03-02 SHR.BN-(D3Rat159-D3Rat1)/Mco    SHR.BN-(D3Rat159-D3Rat1)/Mco    Name updated 68913 APPROVED