Strain Report - Rat Genome Database

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Strain: F344.GK-(D1Swe8-D1Gpam-1)/Swe

Symbol: F344.GK-(D1Swe8-D1Gpam-1)/Swe
Strain: F344.GK-(D1Swe8-D1Gpam-1)
Substrain: Swe
RGD ID: 2316631
Citation ID: RRID:RGD_2316631
Ontology ID: RS:0002369
Alleles: Adra2a;   Shoc2;   Pdcd4
Also Known As: N1I5;F344.GK-(D1Swe8-D1Gpam-1)/Swe; F344.GK-(D1Swe8-D1Gpam-1)/Swe
Type: congenic
Available Source: Not Available
Origination: Karolinska Institutet, Stockholm, Sweden
Description: This sub-congenic strain is generated from an F2- intercross between F344/DuCrlSwe and F344.GK-(D1Arb42a-D1Rat90)/Swe
Last Known Status: Unknown
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21252,645,447 - 252,645,657RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01274,353,782 - 274,353,991RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01281,763,458 - 281,763,667RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41259,866,528 - 259,866,737RGD_MAPPER_PIPELINERGSC3.4





Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. RGD Strain RSO annotation pipeline RGD Automated Pipelines
2. Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes. Rosengren AH, etal., Science. 2010 Jan 8;327(5962):217-20. Epub 2009 Nov 19.

Region

Position Markers

Flank 1 / 1 (D1Swe8)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21252,645,447 - 252,645,657 (+)MAPPER
Rnor_6.01274,353,782 - 274,353,991NCBI
Rnor_5.01281,763,458 - 281,763,667UniSTS
RGSC_v3.41259,866,528 - 259,866,737UniSTS
Celera1248,364,546 - 248,364,755UniSTS
Cytogenetic Map1 RGD

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_life_disease 35% reduction in glucose-stimulated insulin secretion is observed in the islets as compared to F344.GK-(D1Got251-D1Gpam-1)/Swe 2316628
strain_other these have 59% up-regulation of Adra2a mRNA expressiona s compared to F344.GK-(D1Got251-D1Gpam-1)/Swe 2316628
strain_phys_biochem Beta-cells display 50% reduction of exocytosis caused by the additional 1.4 Mb GK-derived segment 2316628