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Strain Registration

Strain: LEW-Tg(H1/tetO-RNAi:Insr)4Hrjb

Symbol: LEW-Tg(H1/tetO-RNAi:Insr)4Hrjb
Strain: LEW-Tg(H1/tetO-RNAi:Insr)4
Substrain: Hrjb
RGD ID: 2314415
Citation ID: RRID:RGD_2314415
Ontology ID: RS:0002056
Alleles: Insr
Previously known as: Tg-4; LEW-Tg(FH1t(Insr)UTG)4Hrjb
Type: transgenic
Source: Department of Cellular and Molecular Immunology, University of Gottingen, Gottingen, Germany
Origin: LEW/Crl rat embryos were microinjected with an lentiviral single vector system comprising of Insr-specific shRNA construct under the control of H1t promoter
Last Known Status: Unknown





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Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. Inducible and reversible gene silencing by stable integration of an shRNA-encoding lentivirus in transgenic rats. Herold MJ, etal., Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18507-12. Epub 2008 Nov 18.
2. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_drgs_chems low doses of doxycycline were used to induce siRNA and ablation of Insr protein expression; dis-continuation reversed the effects 2314405

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-08-17 LEW-Tg(H1/tetO-RNAi:Insr)4Hrjb    LEW-Tg(FH1t(Insr)UTG)4Hrjb    Symbol updated 68687 APPROVED
2017-08-17 LEW-Tg(H1/tetO-RNAi:Insr)4Hrjb    LEW-Tg(FH1t(Insr)UTG)4Hrjb    Symbol updated 68687 APPROVED