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Strain Registration

Strain: KFRS4/Kyo

Symbol: KFRS4/Kyo
Strain: KFRS4
Substrain: Kyo
RGD ID: 2314376
Citation ID: RRID:RGD_2314376
Ontology ID: RS:0002034
Previously known as: SRR04;NBRP Rat No: 0572
Type: mutant
Source: National BioResource Project for the Rat in Japan
Origin: A male rat "TSR Louis" was introduced from American fancy rat colony (Spoiled Ratten Rattery: SRR, in Kansas City, Missouri) to Kyoto University on July 13, 2005. Inbreeding started from F1 progeny of male "TSR Louis" and a female PVG/Seac. This strain carries two mutations, head spot (hs) which causes white spotting on the head, and dumbo (dmbo) which causes abnormal ear morphology (Kuramoto, 2010, RGD:7800655). Ears are set lower on the head, and are larger and rounder. Genetic analyses mapped hs to Chr 15 and dmbo to Chr 14.
Inbred Generations: F16
Last Known Status: Live Animals; Cryopreserved Embryo (as of 2021-10-05)
Research Usage Ophthalmology; Dermatology





Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table

Clinical Measurement
heart rate
systolic blood pressure
body weight
body temperature
red blood cell count
blood hemoglobin level
white blood cell count
platelet count
hematocrit
mean corpuscular volume
plasma glucose level
plasma aspartate aminotransferase activity level
plasma alanine aminotransferase activity level
plasma alkaline phosphatase activity level
plasma total protein level
plasma albumin level
plasma phosphate level
plasma chloride level
plasma sodium level
plasma potassium level
heart wet weight
heart weight to body weight ratio
both kidneys wet weight
lung wet weight
urine potassium level
urine sodium level
brain weight to body weight ratio
both kidneys wet weight as percentage of body weight
liver weight as percentage of body weight
spleen weight to body weight ratio
brain wet weight
lung weight to body weight ratio
liver wet weight
both adrenal glands wet weight
spleen wet weight
both testes wet weight
activated partial thromboplastin time
prothrombin time
timed urine volume
mean corpuscular hemoglobin
mean corpuscular hemoglobin concentration
blood basophil count to total leukocyte count ratio
blood eosinophil count to total leukocyte count ratio
blood lymphocyte count to total leukocyte count ratio
blood monocyte count to total leukocyte count ratio
total plasma calcium level
urine chloride level
plasma creatinine level
plasma triglyceride level
plasma total cholesterol level
plasma urea nitrogen level
both adrenal glands weight to body weight ratio
plasma high density lipoprotein cholesterol level
plasma low density lipoprotein cholesterol level
both testes wet weight to body weight ratio
urine sodium excretion rate to body weight ratio
timed urine volume to body weight ratio
urine chloride excretion rate to body weight ratio
urine potassium excretion rate to body weight ratio
plasma total bilirubin level
blood segmented neutrophil count to total leukocyte count ratio
blood band neutrophil count to total leukocyte count ratio
non-specified leukocyte count to total leukocyte count ratio
plasma albumin to plasma total protein ratio

References

References - curated
# Reference Title Reference Citation
1. Genetic analyses of fancy rat-derived mutations. Kuramoto T, etal., Exp Anim. 2010;59(2):147-55.
2. Atopic dermatitis-like skin lesions with IgE hyperproduction and pruritus in KFRS4/Kyo rats. Kuramoto T, etal., J Dermatol Sci. 2015 Nov;80(2):116-23. doi: 10.1016/j.jdermsci.2015.09.005. Epub 2015 Sep 21.
3. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
4. Deletion of a conserved regulatory element required for Hmx1 expression in craniofacial mesenchyme in the dumbo rat: a newly identified cause of congenital ear malformation. Quina LA, etal., Dis Model Mech. 2012 Nov;5(6):812-22. doi: 10.1242/dmm.009910. Epub 2012 Jun 26.
5. RGD Strain RSO annotation pipeline RGD Automated Pipelines
6. A 5-bp insertion in Mip causes recessive congenital cataract in KFRS4/Kyo rats. Watanabe K, etal., PLoS One. 2012;7(11):e50737. doi: 10.1371/journal.pone.0050737. Epub 2012 Nov 30.
7. A deletion in the intergenic region upstream of Ednrb causes head spot in the rat strain KFRS4/Kyo. Yoshihara M, etal., BMC Genet. 2017 Mar 29;18(1):29. doi: 10.1186/s12863-017-0497-3.

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics Mink mutation (light brown coat color), spot mutation (white spots on head) and dumbo mutation (ear anomaly). 1302502
strain_reproduction Maintained by crossing of heterozygous and homozygous for dumbo gene. Good breeding performance. 1302502

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-05-29 KFRS4/Kyo    KFRS4/Kyo    Name updated 68913 APPROVED