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Strain Registration

Strain: F344-Oune/Kyo

Symbol: F344-Oune/Kyo
Strain: F344-Oune
Substrain: Kyo
Full Name: Oune
RGD ID: 2314162
Citation ID: RRID:RGD_2314162
Ontology ID: RS:0001876
Also Known As: Kyo734;NBRP Rat No: 0464;F344-Oune/Kyo; F344-Oune/Kyo
Type: mutant
Available Source: National BioResource Project for the Rat in Japan
Origination: National BioResource Project for the Rat in Japan
Description: A mutant rat showing abnormal tail was found in the G1 rats produced by ENU mutagenesis (phenotype-driven).
Coat Color: Albino
Last Known Status: Live Animals; Cryopreserved Sperm





Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table

Clinical Measurement
body weight
body temperature
red blood cell count
blood hemoglobin level
white blood cell count
platelet count
hematocrit
mean corpuscular volume
plasma glucose level
plasma aspartate aminotransferase activity level
plasma alanine aminotransferase activity level
plasma alkaline phosphatase activity level
plasma total protein level
plasma albumin level
plasma phosphate level
plasma chloride level
plasma sodium level
plasma potassium level
heart wet weight
heart weight to body weight ratio
both kidneys wet weight
lung wet weight
urine potassium level
urine sodium level
brain weight to body weight ratio
both kidneys wet weight as percentage of body weight
liver weight as percentage of body weight
spleen weight to body weight ratio
brain wet weight
lung weight to body weight ratio
liver wet weight
both adrenal glands wet weight
spleen wet weight
both testes wet weight
timed urine volume
mean corpuscular hemoglobin
mean corpuscular hemoglobin concentration
blood basophil count to total leukocyte count ratio
blood eosinophil count to total leukocyte count ratio
blood lymphocyte count to total leukocyte count ratio
blood monocyte count to total leukocyte count ratio
total plasma calcium level
urine chloride level
plasma creatinine level
plasma triglyceride level
plasma total cholesterol level
plasma urea nitrogen level
both adrenal glands weight to body weight ratio
plasma high density lipoprotein cholesterol level
plasma low density lipoprotein cholesterol level
both testes wet weight to body weight ratio
urine sodium excretion rate to body weight ratio
timed urine volume to body weight ratio
urine chloride excretion rate to body weight ratio
urine potassium excretion rate to body weight ratio
plasma total bilirubin level
blood segmented neutrophil count to total leukocyte count ratio
blood band neutrophil count to total leukocyte count ratio
non-specified leukocyte count to total leukocyte count ratio
plasma albumin to plasma total protein ratio

References

References - curated
# Reference Title Reference Citation
1. Novel ENU-Induced Mutation in Tbx6 Causes Dominant Spondylocostal Dysostosis-Like Vertebral Malformations in the Rat. Abe K, etal., PLoS One. 2015 Jun 19;10(6):e0130231. doi: 10.1371/journal.pone.0130231. eCollection 2015.
2. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Position Markers

Flank 1 / 1 (Tbx6)
Rat AssemblyChrPosition (strand)Source
GRCr81190,818,397 - 190,823,824 (+)NCBI
mRatBN7.21181,387,851 - 181,392,762 (+)NCBI
mRatBN7.2 Ensembl1181,388,684 - 181,392,593 (+)Ensembl
UTH_Rnor_SHR_Utx1189,739,992 - 189,743,901 (+)NCBI
UTH_Rnor_SHRSP_BbbUtx_1.01196,926,065 - 196,929,974 (+)NCBI
UTH_Rnor_WKY_Bbb_1.01189,593,407 - 189,597,316 (+)NCBI
Rnor_6.01198,214,797 - 198,218,706 (+)NCBI
Rnor_6.0 Ensembl1198,214,797 - 198,218,706 (+)Ensembl
Rnor_5.01205,194,665 - 205,198,574 (+)NCBI
RGSC_v3.41185,957,068 - 185,960,977 (+)NCBI
RGSC_v3.11186,106,948 - 186,110,858 (+)NCBI
Celera1179,044,203 - 179,048,112 (+)NCBI
Cytogenetic Map1q36NCBI

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics Morphological defect of tail. Body length is short. 1302502
strain_characteristics the Oune locus spans between D1Mgh36 and D1Rat219 10045933
strain_reproduction Male rats show good breeding performance. Some females show poor breeding performance. Maintained in heterozygous condition by backcrossing onto F344/NSlc. 1302502