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General

Strain: MWF-Chr 8^SHR/Rkb
Symbol:	MWF-Chr 8^SHR/Rkb
Strain:	MWF-Chr 8^SHR
Substrain:	Rkb
RGD ID:	2312609
Citation ID:	RRID:RGD_2312609
Ontology ID:	RS:0002073
Also Known As:	MWF-Chr 8SHR/Rkb;MWF-8^SHR;MWF-8SHR; MWF-Chr 8SHR/Rkb; MWF-Chr 8^[SHR]/Rkb
Type:	consomic
Available Source:	Not Available
Origination:	Department of Clinical Pharmacology and Toxicology, Charite-Universitatsmedizin Berlin, Berlin, Germany
Description:	MWF/FubRkb male was crossed with female SHR/FubRkb to get F1 animals which in turn were backcrossed with female MWF/FubRkb and the desired consomic selected by marker assisted backcrossing
Last Known Status:	Unknown

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

glomerulosclerosis (IAGP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

decreased heart left ventricle weight (IAGP)

decreased kidney weight (IAGP)

decreased systemic arterial systolic blood pressure (IAGP)

increased blood urea nitrogen level (IAGP)

increased circulating creatine level (IAGP)

increased creatinine clearance (IAGP)

increased urine protein level (IAGP)

renal interstitial fibrosis (IAGP)

Phenotype Values via PhenoMiner Click to see Annotation Detail View

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Clinical Measurement

systolic blood pressure

body weight

serum creatinine level

single kidney wet weight

heart left ventricle weight to body weight ratio

kidney glomerulus count

serum urea nitrogen level

single kidney wet weight to body weight ratio

acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel

urine albumin excretion rate

creatinine clearance

heart left ventricle weight

kidney fibrotic lesion area to total kidney area ratio

norepinephrine-induced blood vessel contractile force expressed as percent of force of contraction to KCL

negative logarithm of the molar concentration of norepinephrine at which the force of blood vessel contraction is half the maximum value

References

References - curated

#	Reference Title	Reference Citation
1.	RGD Strain RSO annotation pipeline	RGD Automated Pipelines
2.	Nephron deficit is not required for progressive proteinuria development in the Munich Wistar Fromter rat.	Schulz A, etal., Physiol Genomics. 2008 Sep 17;35(1):30-5. Epub 2008 Jul 22.

Region

Additional Information

RGD Curation Notes

Note Type	Note	Reference
strain_life_disease	male F₁ animals had a significantly higher urinary albumin excretion levels	2312602
strain_life_disease	suppressed early onset of albuminuria and diminished proteinuria	2312602

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
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InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Strain: MWF-Chr 8SHR/Rkb

Mammalian Phenotype

Related Phenotype Data for Term "MWF-Chr 8SHR/Rkb" (RS:0002073)

Strain: MWF-Chr 8^SHR/Rkb