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Strain: DRH.F344-(D1Mgh8-D1Mgh12)/Shigm

Symbol: DRH.F344-(D1Mgh8-D1Mgh12)/Shigm
Strain: DRH.F344-(D1Mgh8-D1Mgh12)
Substrain: Shigm
RGD ID: 2304125
Citation ID: RRID:RGD_2304125
Ontology ID: RS:0001862
Also Known As: DRH.F344-Drh1/Shigm; DRH.F344-(D1Mgh8-D1Mgh12)/Kyo; DRH.F344-(D1Mgh8-D1Mgh12)/Kyo; NBRP Rat No: 0241; DRH.F344-Drh1/Shigm; DRH.F344-(D1Mgh8-D1Mgh12)/Shigm
Type: congenic
Available Source: National BioResource Project for the Rat in Japan, Department of Pathology and Biology of Diseases, Graduate School of Medicine, Kyoto University, Japan
Origination: National BioResource Project for the Rat in Japan, Department of Pathology and Biology of Diseases, Graduate School of Medicine, Kyoto University, Japan
Description: desired fragment from F344 was introgressed into DRH background
Coat Color: Albino
Inbred Generations: F30
Last Known Status: Cryopreserved Embryo; Cryopreserved Sperm
Research Usage Diabetes Obesity; Cancer
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21153,136,852 - 153,136,969RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01163,796,316 - 163,796,432RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01169,999,389 - 270,717,037RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41156,124,624 - 247,322,277RGD_MAPPER_PIPELINERGSC3.4





Experimental Data Annotations    Click to see Annotation Detail View

Rat Strain
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
DRH.F344-(D1Mgh8-D1Mgh12)/Shigm  IEA 7241799 RGD 

Vertebrate Trait
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
liver integrity trait  EXP 1358145 RGD 

Phenotype Values via Phenominer Click to see Annotation Detail View

Related Phenotype Data for Term "DRH.F344-(D1Mgh8-D1Mgh12)/Shigm" (RS:0001862)

Rat Strains:
Clinical Measurements:
Experimental Conditions:
Measurement Methods:

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table

Clinical Measurement
heart rate
systolic blood pressure
body weight
body temperature
red blood cell count
blood hemoglobin level
white blood cell count
platelet count
hematocrit
mean corpuscular volume
plasma glucose level
plasma aspartate aminotransferase activity level
plasma alanine aminotransferase activity level
plasma alkaline phosphatase activity level
plasma total protein level
plasma albumin level
plasma phosphate level
plasma chloride level
plasma sodium level
plasma potassium level
heart wet weight
heart weight to body weight ratio
both kidneys wet weight
lung wet weight
urine potassium level
urine sodium level
brain weight to body weight ratio
both kidneys wet weight as percentage of body weight
liver weight as percentage of body weight
spleen weight to body weight ratio
brain wet weight
lung weight to body weight ratio
liver wet weight
both adrenal glands wet weight
spleen wet weight
both testes wet weight
activated partial thromboplastin time
prothrombin time
timed urine volume
mean corpuscular hemoglobin
mean corpuscular hemoglobin concentration
blood basophil count to total leukocyte count ratio
blood eosinophil count to total leukocyte count ratio
blood lymphocyte count to total leukocyte count ratio
blood monocyte count to total leukocyte count ratio
total plasma calcium level
urine chloride level
plasma creatinine level
plasma triglyceride level
plasma total cholesterol level
plasma urea nitrogen level
both adrenal glands weight to body weight ratio
plasma high density lipoprotein cholesterol level
plasma low density lipoprotein cholesterol level
both testes wet weight to body weight ratio
area of individual liver tumorous lesion
area of liver occupied by tumorous lesions as percentage of total liver area
area of liver occupied by fibrotic lesions to total liver area ratio
TUNEL-positive cell number to total cell number ratio
liver tumorous lesion number to liver area ratio
urine sodium excretion rate to body weight ratio
timed urine volume to body weight ratio
urine chloride excretion rate to body weight ratio
urine potassium excretion rate to body weight ratio
plasma total bilirubin level
blood segmented neutrophil count to total leukocyte count ratio
blood band neutrophil count to total leukocyte count ratio
non-specified leukocyte count to total leukocyte count ratio
plasma albumin to plasma total protein ratio

References

References - curated
# Reference Title Reference Citation
1. Role of resistant Drh1 locus in chemical carcinogen-induced hepatocarcinogenesis in rats: analysis with a speed congenic strain. Liu H, etal., Cancer Sci 2005 Mar;96(3):164-9.
2. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines
4. Resistance of DRH strain rats to chemical carcinogenesis of liver: genetic analysis of later progression stage. Yan Y, etal., Carcinogenesis 2002 Jan;23(1):189-96.
5. Genetic resistance to chemical carcinogen-induced preneoplastic hepatic lesions in DRH strain rats. Zeng ZZ, etal., Cancer Res 2000 Jun 1;60(11):2876-81.

Region

Position Markers

Flank 1 / 1 (D1Mgh8)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21153,136,852 - 153,136,969 (+)MAPPER
Rnor_6.01163,796,316 - 163,796,432NCBI
Rnor_5.01169,999,389 - 169,999,505UniSTS
RGSC_v3.41156,124,624 - 156,124,741RGD
RGSC_v3.41156,124,625 - 156,124,741UniSTS
RGSC_v3.11156,203,030 - 156,203,147RGD
Celera1151,223,327 - 151,223,443UniSTS
RH 3.4 Map11215.0UniSTS
RH 3.4 Map11215.0RGD
RH 2.0 Map1788.6RGD
Cytogenetic Map1q32UniSTS

Flank 2 / 1 (D1Mgh12)
Rat AssemblyChrPosition (strand)Source
Rnor_5.01270,716,905 - 270,717,037NCBI
RGSC_v3.41247,322,146 - 247,322,277RGD
RGSC_v3.11247,436,621 - 247,436,752RGD
Celera1238,204,080 - 238,204,181UniSTS
RH 3.4 Map11616.91UniSTS
RH 3.4 Map11616.91RGD
RH 2.0 Map11221.1RGD
SHRSP x BN Map1133.51RGD
Cytogenetic Map1q54UniSTS
Strain QTL Data
Symbol Name Trait
Hcar15 Hepatocarcinoma resistance QTL 15 liver integrity trait   (VT:0010547)    

Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-09-13 DRH.F344-(D1Mgh8-D1Mgh12)/Shigm    DRH.F344-D1Mgh8-D1Mgh12/Shigm    Symbol updated 68687 APPROVED
2012-09-13 DRH.F344-(D1Mgh8-D1Mgh12)/Shigm    DRH.F344-D1Mgh8-D1Mgh12/Shigm    Name updated 68913 APPROVED
2012-09-13 DRH.F344-(D1Mgh8-D1Mgh12)/Shigm    DRH.F344-D1Mgh8-D1Mgh12/Shigm    Symbol updated 68687 APPROVED
2012-09-13 DRH.F344-(D1Mgh8-D1Mgh12)/Shigm    DRH.F344-D1Mgh8-D1Mgh12/Shigm    Name updated 68913 APPROVED
2012-05-15 DRH.F344-D1Mgh8-D1Mgh12/Shigm    DRH.F344-D1Mgh8-D1Mgh12/Shigm    Name updated 68913 APPROVED
2012-05-15 DRH.F344-D1Mgh8-D1Mgh12/Shigm    DRH.F344-D1Mgh8-D1Mgh12/Shigm    Name updated 68913 APPROVED
2011-03-22 DRH.F344-D1Mgh8-D1Mgh12/Shigm    DRH.F344-Drh1/Shigm    Symbol updated 68687 APPROVED
2011-03-22 DRH.F344-D1Mgh8-D1Mgh12/Shigm    DRH.F344-Drh1/Shigm    Name updated 68913 APPROVED
2011-03-22 DRH.F344-D1Mgh8-D1Mgh12/Shigm    DRH.F344-Drh1/Shigm    Symbol updated 68687 APPROVED
2011-03-22 DRH.F344-D1Mgh8-D1Mgh12/Shigm    DRH.F344-Drh1/Shigm    Name updated 68913 APPROVED