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Strain: WIC-Tgrdw/Kts

Symbol: WIC-Tgrdw/Kts
Strain: WIC-Tgrdw
Substrain: Kts
RGD ID: 2304039
RRID: RGD_2304039
Ontology ID: RS:0002259
Alleles: Tgrdw
Also known as: WIC-Tgm1Kts; WIC-Tgrdw/Kts; WIC-Tgrdw/Kts; NBRP Rat No: 0104; rdw; WIC-rdw; WIC-rdw; WI-TgrdwKts; WIC-Tgrdw/Kts
Type: mutant
Source: National BioResource Project for the Rat in Japan
Origin: Established from a closed colony of Wistar-Imamichi (WIC) rats as a spontaneous mutant exhibiting congenital dwarfism (rdw), is inherited as an autosomal recessive. This strain has a spontaneous missense mutation, G2320R, in the thyroglobul gene.
Inbred Generations: F15
Last Known Status: Cryopreserved Embryo; Cryopreserved Sperm (as of 2017-04-21)
Research Usage Metabolism
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2798,418,293 - 98,603,210RGD_MAPPER_PIPELINE
Rnor_6.07107,467,260 - 107,652,897RGD_MAPPER_PIPELINERnor6.0
Rnor_5.07107,399,165 - 107,602,400RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.47104,035,776 - 104,220,754RGD_MAPPER_PIPELINERGSC3.4

Mutant Strains
F344.WIC-TgrdwKts




Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References


Region

Rat Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type
Tgrdw-var1 chr7 107567063 107567063 G C point_mutation

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics A missense mutation, G2320R, in the Tg gene is responsible for the rdw mutation in the WIC-rdw rat. 1302502
strain_phys_biochem elevated molecular chaperone levels were observed in the thyrocytes 1302502
strain_reproduction Homozygous rdw rats are infertile in both sexes. So, the mutant rats are maintained as a segregating inbred strain. 1302502

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-04-28 WIC-Tgrdw/Kts    WIC-TgrdwKts    Symbol updated 68687 APPROVED
2017-04-28 WIC-Tgrdw/Kts    WIC-TgrdwKts    Symbol updated 68687 APPROVED
2017-04-21 WIC-TgrdwKts    WI-TgrdwKts    Symbol updated 68687 APPROVED
2017-04-21 WIC-TgrdwKts    WI-TgrdwKts    Symbol updated 68687 APPROVED
2012-05-09 WIC-TgrdwKts    WIC-TgrdwKts    Name updated 68913 APPROVED
2010-06-08 WIC-TgrdwKts/    WIC-Tgrdw/Kts    Symbol updated 68687 APPROVED
2010-06-08 WIC-TgrdwKts/    WIC-Tgrdw/Kts    Symbol updated 68687 APPROVED
2010-06-08 WIC-TgrdwKts    WIC-TgrdwKts/    Name updated 68913 APPROVED
2010-06-08 WIC-TgrdwKts    WIC-TgrdwKts/    Symbol updated 68687 APPROVED
2010-06-08 WIC-TgrdwKts    WIC-TgrdwKts/    Name updated 68913 APPROVED
2010-06-08 WIC-TgrdwKts    WIC-TgrdwKts/    Symbol updated 68687 APPROVED
2010-06-08 WIC-TgrdwKts/    WIC-Tgrdw/Kts    Name updated 68913 APPROVED
2010-06-08 WIC-TgrdwKts/    WIC-Tgrdw/Kts    Name updated 68913 APPROVED