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Strain Registration

Strain: DA.ACI-(D2Mit12-D2Mgh29)/Nsi

Symbol: DA.ACI-(D2Mit12-D2Mgh29)/Nsi
Strain: DA.ACI-(D2Mit12-D2Mgh29)
Substrain: Nsi
RGD ID: 2302387
Citation ID: RRID:RRRC_00667
Ontology ID: RS:0001692
Also Known As: DA.ACI(Cia10);DA.ACI-(D2Mit12-D2Mgh29)/Nsi; DA.ACI-(D2Mit12-D2Mgh29)/Nsi
Type: congenic
Available Source: Rat Resource and Research Center
Origination: North Shore-Long Island Jewish Research Institute,350 Community Drive - Manhasset, NY 11030.
Description: Congenic strain created by backcrossing DA/BklArbNsi and ACI/SegHsd which resulted in introgressing a 52.6 Mb from ACI into DA/BklArbNsi
Coat Color: agouti
Last Known Status: Cryopreserved Sperm (as of 2019-02-18)
Research Usage arthritis/autoimmunity studies
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr82170,656,145 - 221,089,121RGD_MAPPER_PIPELINE
mRatBN7.22168,358,098 - 218,414,891RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.02181,990,297 - 235,290,110RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0274,640,967 - 201,405,160RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.42174,730,375 - 227,310,008RGD_MAPPER_PIPELINERGSC3.4





Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. The non-major histocompatibility complex quantitative trait locus Cia10 contains a major arthritis gene and regulates disease severity, pannus formation, and joint damage. Brenner M, etal., Arthritis Rheum 2005 Jan;52(1):322-32.
2. The arthritis severity locus Cia5d is a novel genetic regulator of the invasive properties of synovial fibroblasts. Laragione T, etal., Arthritis Rheum. 2008 Aug;58(8):2296-306.
3. Data registered by the Rat Resource & Research Center Personal Communication with Rat Resource & Research Center
4. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Position Markers

Flank 1 / 1 (D2Mit12)
Rat AssemblyChrPosition (strand)Source
GRCr82170,656,145 - 170,656,389 (+)Marker Load Pipeline
mRatBN7.22168,358,098 - 168,358,342 (+)MAPPER
Rnor_6.02181,990,297 - 181,990,540NCBI
Rnor_5.02201,404,917 - 201,405,160UniSTS
RGSC_v3.42174,730,375 - 174,730,618UniSTS
Celera2162,384,792 - 162,385,042UniSTS
RH 3.4 Map21094.5RGD
RH 3.4 Map21094.5UniSTS
FHH x ACI Map275.4999RGD
FHH x ACI Map275.4999UniSTS
Cytogenetic Map2q31-q34UniSTS

Flank 2 / 1 (D2Mgh29)
Rat AssemblyChrPosition (strand)Source
GRCr82221,088,977 - 221,089,121 (+)Marker Load Pipeline
mRatBN7.22218,414,747 - 218,414,891 (+)MAPPER
Rnor_6.02235,289,967 - 235,290,110NCBI
Rnor_5.0274,640,967 - 74,641,110UniSTS
RGSC_v3.42227,309,864 - 227,310,008RGD
RGSC_v3.42227,309,865 - 227,310,008UniSTS
RGSC_v3.12227,296,545 - 227,296,688RGD
Celera2210,697,016 - 210,697,159UniSTS
RH 3.4 Map21547.1UniSTS
RH 3.4 Map21547.1RGD
RH 2.0 Map21130.1RGD
Cytogenetic Map2q43UniSTS

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_life_disease Both males and females develop a milder form of arthritis as compared to DA 1358860
strain_other Synovial tissue of these was preserved as compared to DA including no cartilage and bone erosions, synovial hyperplasia and pannus formation 1358860
strain_other Fibroblast-like synoviocytes (FLS) have similar number of invading cells as DA 2302383
strain_other ACI alleles between: D2Mit12 and ENSRNOSNP2787119. DA alleles at: D2Rat38 and D2Mgh18. 2292495

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-10-14 DA.ACI-(D2Mit12-D2Mgh29)/Nsi    DA.ACI-(D2Mit12-D2Mgh29)/Nsi    Name updated 68913 APPROVED
2013-10-14 DA.ACI-(D2Mit12-D2Mgh29)/Nsi    DA.ACI-(D2Mit12-D2Mgh29)/Nsi    Name updated 68913 APPROVED
2013-10-14 DA.ACI-(D2Mit12-D2Mgh29)/Nsi    DA.ACI-(D2Mit12-D2Mgh29)/Nsi    Name updated 68913 APPROVED
2013-10-14 DA.ACI-(D2Mit12-D2Mgh29)/Nsi    DA.ACI-(D2Mit12-D2Mgh29)/Nsi    Name updated 68913 APPROVED
2013-10-14 DA.ACI-(D2Mit12-D2Mgh29)/Nsi    DA.ACI-(D2Mit12-D2Mgh29)/Nsi    Name updated 68913 APPROVED
2013-10-14 DA.ACI-(D2Mit12-D2Mgh29)/Nsi    DA.ACI-(D2Mit12-D2Mgh29)/Nsi    Name updated 68913 APPROVED
2013-07-29 DA.ACI-(D2Mit12-D2Mgh29)/Nsi    DA.ACI-(D2Mit12-D2Mgh29)/Nsi    Name updated 68913 APPROVED
2013-07-29 DA.ACI-(D2Mit12-D2Mgh29)/Nsi    DA.ACI-(D2Mit12-D2Mgh29)/Nsi    Name updated 68913 APPROVED

Database Acc Id Source(s)
RRRC RRRC:00667 RGD