Strain Report - Rat Genome Database

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Strain: SHR-Tg(PEPCK-SREBF1)1Ipcv

Symbol: SHR-Tg(PEPCK-SREBF1)1Ipcv
Strain: SHR-Tg(PEPCK-SREBF1)1
Substrain: Ipcv
RGD ID: 2300216
Citation ID: RRID:RGD_2300216
Ontology ID: RS:0001639
Alleles: SREBF1
Previously known as: SHR-Tg(PEPCK-SREBP-1c)Ipcv
Type: transgenic
Source: Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic
Origin: SHR/OlaIpcv zygotes were microinjected with a construct containing rat PEPCK promoter fused to truncated human cDNA encoding SREBF1 (SREBP-1c isoform) and human growth hormone poly-A signal
Last Known Status: Unknown





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Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. Identification of mutated Srebf1 as a QTL influencing risk for hepatic steatosis in the spontaneously hypertensive rat. Pravenec M, etal., Hypertension. 2008 Jan;51(1):148-53. Epub 2007 Dec 10.
2. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_other Increased hepatic activity of SREBP-1 was observed due to positive form of SREBP-1c in the liver 1643359