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Strain Registration

Strain: WFfzHsd

Symbol: WFfzHsd
Strain: WFfz
Substrain: Hsd
Full Name: Fuzzy rat
RGD ID: 2298772
Citation ID: RRID:RRRC_00340
Ontology ID: RS:0001591
Also Known As: Hsd:FUZZY-fz; WFfzHsd; WF^[fzHsd]
Type: mutant
Available Source: Rat Resource and Research Center
Origination: Tulane University to Skin and Cancer Hospital, Temple University, Philadelphia
Description: Sparse fuzzy hair animals with Wistar Furth background found at Tulane University to Skin and Cancer Hospital, Temple University, Philadelphia to Harlan (1987)
Coat Color: White
Last Known Status: Cryopreserved Embryo; Cryopreserved Sperm (as of 2023-12-14)





Disease Annotations     Click to see Annotation Detail View
hair disease  (IAGP)
hypotrichosis  (IAGP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
fuzzy hair  (IAGP)

References

References - curated
# Reference Title Reference Citation
1. The charles river "Hairless" rat mutation maps to chromosome 1: allelic with fuzzy and a likely orthologue of mouse frizzy. Ahearn K, etal., J Hered 2002 May-Jun;93(3):210-3.
2. Three variations of hairlessness associated with albinism in the laboratory rat. Ferguson FG, etal., Lab Anim Sci. 1979 Aug;29(4):459-64.
3. Data registered by the Rat Resource & Research Center Personal Communication with Rat Resource & Research Center
4. RGD Strain RSO annotation pipeline RGD Automated Pipelines
5. The mouse frizzy (fr) and rat 'hairless' (frCR) mutations are natural variants of protease serine S1 family member 8 (Prss8). Spacek DV, etal., Exp Dermatol. 2010 Jun;19(6):527-32. doi: 10.1111/j.1600-0625.2009.01054.x. Epub 2010 Feb 25.
6. Percutaneous penetration and metabolism of 2-nitro-p-phenylenediamine in human and fuzzy rat skin. Yourick JJ and Bronaugh RL, Toxicol Appl Pharmacol. 2000 Jul 1;166(1):13-23.

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_drgs_chems 2-Nitro-p-phenylenediamine (2NPPD) a coal-tar dye, is absorbed and metabolized in skin and intestinal tissues 2298770
strain_other backcrossing produced hybrid animals showing mutations are allelic 625461
strain_reproduction breeding: random intra-strain 2292495
strain_reproduction litter size:8-10 2292495

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-04-19 WFfzHsd  Fuzzy rat  WFfzHsd  Fuzzy rat  Name updated 68913 APPROVED

Database Acc Id Source(s)
RRRC RRRC:00340 RGD