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Strain Registration

Strain: ISIAH

Symbol: ISIAH
Strain: ISIAH
Full Name: Inherited stress-induced arterial hypertension
RGD ID: 2292168
Citation ID: RRID:RGD_2292168
Ontology ID: RS:0001334
Type: inbred
Source: Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia
Origin: Selected from an outbred population of Wistar rats at the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia, for increased response of blood pressure (systolic) which was induced by restraining the animals in a cylindrical wire mess that caused a mild emotional stress
Inbred Generations: F21
Last Known Status: Unknown





Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
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Clinical Measurement
systolic blood pressure
diastolic blood pressure
body weight
heart wet weight
heart weight to body weight ratio
both kidneys wet weight
both adrenal glands wet weight
both kidneys wet weight to body weight ratio
gestation period length
plasma triglyceride level
plasma total cholesterol level
thymus weight to body weight ratio
both adrenal glands weight to body weight ratio
litter size
percentage of experiment time spent in a discrete space in an experimental apparatus
number of entries into a discrete space in an experimental apparatus
percentage of entries into a discrete space in an experimental apparatus
number of stretched-attend posture movements
plasma corticosterone level
total horizontal distance resulting from voluntary locomotion in an experimental apparatus
plasma high density lipoprotein phospholipid level
duration of grooming in an experimental apparatus
number of rearing movements in an experimental apparatus
spleen cell count
blood non-specified leukocyte count
both adrenal glands wet weight to body weight ratio
CD3+ thymocyte count
CD4+CD8+ thymocyte count
CD4-CD8+ thymocyte count
CD4+CD25+ thymocyte count
CD4+CD25+ splenocyte count
CD3+ splenocyte count
CD11b/c+ splenocyte count
CD4+CD25+ splenocyte count to total splenocyte count ratio
CD11b/c+ splenocyte count to total splenocyte count ratio
CD45RA+ splenocyte count to total splenocyte count ratio
CD4-CD25+ splenocyte count
percentage of 13 cm2 floor sectors crossed into, out of or within a discrete space in an experimental apparatus
time to first grooming within an experimental apparatus
time to first rearing within an experimental apparatus
number of head dipping movements in an experimental apparatus
time to first head dip within an experimental apparatus
amount of time spent making head dipping movements in an experimental apparatus
amount of time spent making stretched-attend posture movements in an experimental apparatus
time to first stretched-attend posture movement within an experimental apparatus
amount of time spent exploring a novel object in an experimental apparatus
amount of time spent exploring a familiar object in an experimental apparatus

References

References - curated
# Reference Title Reference Citation
1. Candidate genes in quantitative trait loci associated with absolute and relative kidney weight in rats with Inherited Stress Induced Arterial Hypertension. Redina OE, etal., BMC Genet. 2015;16 Suppl 1:S1. doi: 10.1186/1471-2156-16-S1-S1. Epub 2015 Feb 2.
2. Genetic control of the corticosterone level at rest and under emotional stress in ISIAH rats with inherited stress-induced arterial hypertension. Redina OE, etal., Clin Exp Hypertens. 2010;32(6):364-71. doi: 10.3109/10641961003628502.
3. The genetic control of blood pressure and body composition in rats with stress-sensitive hypertension. Redina OE, etal., Clin Exp Hypertens. 2013;35(7):484-95. doi: 10.3109/10641963.2012.758274. Epub 2013 Jan 9.
4. Rats with inherited stress-induced arterial hypertension (ISIAH strain) display specific quantitative trait loci for blood pressure and for body and kidney weight on chromosome 1. Redina OE, etal., Clin Exp Pharmacol Physiol. 2006 May-Jun;33(5-6):456-64.
5. The characteristics of motor activity in ISIAH rats in an open field test are controlled by genes on chromosomes 2 and 16. Redina OE, etal., Neurosci Behav Physiol. 2009 Jan;39(1):57-64. Epub 2008 Dec 17.
6. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Strain QTL Data
Symbol Name Trait
Activ3 Activity QTL 3 locomotor behavior trait   (VT:0001392)    
Activ4 Activity QTL 4 locomotor behavior trait   (VT:0001392)    
Activ5 Activity QTL 5 locomotor behavior trait   (VT:0001392)    
Bp306 Blood pressure QTL 306 arterial blood pressure trait   (VT:2000000)    
Bp307 Blood pressure QTL 307 arterial blood pressure trait   (VT:2000000)    
Bp377 Blood pressure QTL 377 arterial blood pressure trait   (VT:2000000)    
Bp378 Blood pressure QTL 378 arterial blood pressure trait   (VT:2000000)    
Bw173 Body weight QTL 173 body mass   (VT:0001259)    
Bw174 Body weight QTL 174 body mass   (VT:0001259)    
Bw80 Body weight QTL 80 body mass   (VT:0001259)    
Gmadr2 Adrenal mass QTL 2 adrenal gland mass   (VT:0010420)    
Gmadr3 Adrenal mass QTL 3 adrenal gland mass   (VT:0010420)    
Gmadr4 Adrenal mass QTL 4 adrenal gland mass   (VT:0010420)    
Gmadr5 Adrenal mass QTL 5 adrenal gland mass   (VT:0010420)    
Gmadr6 Adrenal mass QTL 6 adrenal gland mass   (VT:0010420)    
Gmadr7 Adrenal mass QTL 7 adrenal gland mass   (VT:0010420)    
Kidm35 Kidney mass QTL 35 kidney mass   (VT:0002707)    
Kidm44 Kidney mass QTL 44 kidney mass   (VT:0002707)    
Kidm45 Kidney mass QTL 45 kidney mass   (VT:0002707)    
Kidm46 Kidney mass QTL 46 kidney mass   (VT:0002707)    
Kidm47 Kidney mass QTL 47 kidney mass   (VT:0002707)    
Kidm48 Kidney mass QTL 48 kidney mass   (VT:0002707)    
Kidm49 Kidney mass QTL 49 kidney mass   (VT:0002707)    
Kidm50 Kidney mass QTL 50 kidney mass   (VT:0002707)    
Kidm51 Kidney mass QTL 51 kidney mass   (VT:0002707)    
Kidm52 Kidney mass QTL 52 kidney mass   (VT:0002707)    
Kidm53 Kidney mass QTL 53 kidney mass   (VT:0002707)    
Kidm54 Kidney mass QTL 54 kidney mass   (VT:0002707)    
Scort23 Serum corticosterone level QTL 23 blood corticosterone amount   (VT:0005345)    
Scort24 Serum corticosterone level QTL 24 blood corticosterone amount   (VT:0005345)    
Scort25 Serum corticosterone level QTL 25 blood corticosterone amount   (VT:0005345)    
Scort26 Serum corticosterone level QTL 26 blood corticosterone amount   (VT:0005345)    
Scort27 Serum corticosterone level QTL 27 blood corticosterone amount   (VT:0005345)    
Scort28 Serum corticosterone level QTL 28 blood corticosterone amount   (VT:0005345)    
Srcrt6 Stress Responsive Cort QTL 6 blood corticosterone amount   (VT:0005345)    
Srcrt7 Stress Responsive Cort QTL 7 blood corticosterone amount   (VT:0005345)    
Srcrt8 Stress Responsive Cort QTL 8 blood corticosterone amount   (VT:0005345)    
Srcrt9 Stress Responsive Cort QTL 9 blood corticosterone amount   (VT:0005345)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_other Systolic blood pressure increased to 195 mmHg in males and 174 mmHg in females 1626643